CAS: 3335-98-6; 1-Phenyloxindole

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2-氯-N,N-二苯基乙酰胺置于aluminum (Iii) Chloride,Sodium Chloride体系中,化学反应生成 N-苯基吲哚酮
参考文献:四氢硫吡喃并[2,3-B]吲哚[60]富勒烯衍生物的合成通过c60和α,β-不饱和吲哚-2-硫酮的杂diels-Alder反应
标题:四氢硫吡喃并[2,3-B]吲哚[60]富勒烯衍生物的合成通过c60和α,β-不饱和吲哚-2-硫酮的杂diels-Alder反应
摘要:[60]富勒烯与α,β-不饱和硫代氧杂吲哚(3A,3B,3C)的杂diels-Alder反应,由硫代氧吲哚1和杂芳族醛(2A,2B,2C)制备,反应生成四氢噻喃[2]描述了在热或微波辐射下,3-B]吲哚[60]富勒烯环加合物(5A,5B,5C).通过在微波辐射下进行反应,提高了产率,并且减少了反应时间.
DOI:10.1002/jhet.2653

专利信息

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:WO-2025039354-A1
优先权日:2023-08-23
标 题:Intermediate compound of oxcarbazepine and preparation method therefor
发明人：ZHAO JIANHONG; LI YONGGANG; XU YINGZHOU; ZHENG CHENGHAO
权利人:ZHEJIANG JIUZHOU PHARM CO LTD; ZHEJIANG RAYBOW PHARMACEUTICAL CO LTD
摘要:The present invention relates to the field of pharmaceutical synthesis, and specifically relates to a method for preparing a key intermediate of oxcarbazepine. Specifically, a compound represented by formula A is prepared from a compound represented by formula 4 under the action of a ring-opening reagent and selectively under the action of an esterification reagent, a protective reagent, a hydrolysis reagent and a chlorination reagent; a compound represented by formula 10 is prepared from the compound represented by formula A by means of a ring-closing reaction; and finally oxcarbazepine is prepared from the compound represented by formula 10. The route of the present invention achieves a relatively high conversion rate, and is more advantageous in the aspect of cost control. The reaction formulas are shown in formula (I), wherein R3 is OR1 or R2; R1 is hydrogen, a C1-C6 alkyl or substituted alkyl, or Na, K or Li; R2 is Cl or -OCOR5; R5 is a C1-C6 alkyl or substituted alkyl, an aryl, a substituted aryl, a phenyl, a benzyl or a substituted benzyl; and R4 is a C1-C6 alkyl, a substituted alkyl, an aryl, a substituted aryl, a benzyl or a substituted benzyl.

专利号:US-8497296-B2
优先权日:2011-03-31
标 题:N,N′-hydrazino-bis-isatin derivatives with selective activity against multidrug-resistant cancer cells
发明人：HASSAN TAREK ABOUL-FADL MOHAMED; KADI ADNAN AHMED; ABDEL-AZIZ HATEM ABDEL-KHADER
权利人:HASSAN TAREK ABOUL-FADL MOHAMED; KADI ADNAN AHMED; ABDEL-AZIZ HATEM ABDEL-KHADER; UNIV KING SAUD
摘要:The invention is directed to a compound of Formula (I), n nwherein R is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; R 1 is selected from the group consisting of hydrogen atom and unsubstituted or substituted phenyl group; X is selected from the group consisting of hydrogen atom or halogen atom; and Y is selected from the group consisting of hydrogen atom, halogen atom, C 1 -C 4 alkyl group, nitro group, and —OCF 3 group, as well as for its use in therapy, preferably for the treatment of cancer, and to a related pharmaceutical composition, the use of the compound for the manufacture of a medicament for the respective medical indication, and a method of synthesis of the compounds of the invention.

专利号:US-5382593-A
优先权日:1992-07-21
标 题 :New 3-(hydroxybenzylidenyl)-indolin-2-ones
发明人：LE BAUT GUILLAUME; NOURRISSON MARIE-RENEE; RENAUD DE LA FAVERIE JEAN-FRAN; BIZOT ESPIARD JEAN-GUY; CAIGNARD DANIEL-HENRI; RENARD PIERRE; ADAM GERARD
权利人:ADIR
摘要:The invention relates to a compound selected from those of formula (I): (I) wherein R1, R2, R3, R4, R5 and X are as defined in the description, its Z and E isomers, its optical isomers, in pure form or in the form of a mixture, and its addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful in treating a disorder resulting from or associated with peroxidation phenomena, disturbances in eicosanoid synthesis, or with platelet aggregation disorders.