专利号:US-2024110196-A1 优先权日:2022-08-29 标题 :Use of multigene stacking method in synthesis of nervonic acid in brassica napus 发明人:LIU FANG; WANG PANDI; WU GANG; XIONG XIAOJUAN 权利人:OIL CROPS RES INSTITUTE CAAS 摘要:The present disclosure relates to use of a multigene stacking method in synthesis of nervonic acid in Brassica napus. The present disclosure provides a multigene co-expression plant vector, including an initial backbone of pBWA(V)BII and multiple exogenous gene expression cassettes. The present disclosure further provides two plant vectors applicable to genetic transformation, including a three-gene co-expression plant vector and a five-gene co-expression plant vector. In the present disclosure, after the three-gene co-expression plant vector and the five-gene co-expression plant vector are separately transferred into the Brassica napus, the nervonic acid (NA) with a high content is synthesized in the Brassica napus through multigene co-expression. An NA ratio can be significantly increased combined with a higher seed oil content and a greater field seed yield. The plant vector realizes efficient synthesis of NA in oil crops, obtains NA-rich seed oil, and increases an added value of edible oil.
专利号:US-9693999-B2 优先权日:2011-01-26 标题:Small molecule RNase inhibitors and methods of use 发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE 权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education 摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.
专利号:US-2007203079-A1 优先权日:2005-11-21 标题:Methods of using small molecule compounds for neuroprotection 发明人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG 权利人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG 摘要:Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.
专利号:WO-2009056955-A1 优先权日:2007-10-30 标题 :Amine-bearing phospholipids (abps), their synthesis and use 发明人:ZUMBUEHL ANDREAS 权利人:UNIV BASEL; ZUMBUEHL ANDREAS 摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.
专利号:US-9868747-B2 优先权日:2014-02-18 标题:Marinopyrrole derivatives and methods of making and using same 发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI 权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD 摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.
专利号:US-2025043324-A1 优先权日:2021-07-28 标 题:A low-cost, thermostable, lyophilized, cell-free protein synthesis platform 发明人:JEWETT MICHAEL CHRISTOPHER; WARFEL KATHERINE F 权利人:UNIV NORTHWESTERN 摘要:The present disclosure relates to stable, cost-effective, cell-free systems, compositions, methods, and kits for bio-manufacturing proteins. The systems, methods, and kits allow for cell-free bio-manufacturing of desired products in cell-free conditions, wherein the system can be stably stored or transported, in lyophilized form, at temperatures up to 50° C. for several weeks prior to use.
1: Lee K, Lee KM, Go J, Ryu JC, Ryu JH, Yoon SS. The ferrichrome receptor A as a new target for Pseudomonas aeruginosa virulence attenuation. FEMS Microbiol Lett. 2016 Jun;363(11). pii: fnw104. doi: 10.1093/femsle/fnw104. Epub 2016 Apr 18. doi: 10.1186/s12866-016-0696-5. 3: Batra P, Mathur P, Misra MC. Aeromonas spp.: An Emerging Nosocomial Pathogen. J Lab Physicians. 2016 Jan-Jun;8(1):1-4. doi: 10.4103/0974-2727.176234. Review. 4: Kalantar-Neyestanaki D, Emaneini M, Jabalameli F, Taherikalani M, Mirsalehian A. ISPpu22, a novel insertion sequence in the oprD porin gene of a carbapenem-resistant Pseudomonas aeruginosa isolate from a burn patient in Tehran, Iran. Iran J Microbiol. 2015 Oct;7(5):247-50.
合成参考文献
摘要:Gekkan Yakuji. Pharmaceuticals Monthly., 11(1589), 1969 摘要:Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories., 34(405), 1975 参考文献:10.1007/s00299-004-0789-8 摘要:Cho HJ, Brotherton JE, Widholm JM. Use of the tobacco feedback-insensitive anthranilate synthase gene (ASA2) as a selectable marker for legume hairy root transformation. Plant Cell Rep. 2004 Aug;23(1-2):104–13. doi: 10.1007/s00299-004-0789-8. 参考文献:10.1007/978-1-59745-191-8_17 摘要:Tanaka Y, Nakamura N, Togami J. Altering flower color in transgenic plants by RNAi-mediated engineering of flavonoid biosynthetic pathway. Methods Mol Biol. 2008;442():245–57. doi: 10.1007/978-1-59745-191-8_17. 参考文献:10.1007/s00299-003-0731-5 摘要:ur Rahman L, Ikenaga T, Kitamura Y. Penicillin derivatives induce chemical structure-dependent root development, and application for plant transformation. Plant Cell Rep. 2004 Apr;22(9):668–77. doi: 10.1007/s00299-003-0731-5.