专利号:EP-4423083-A2 优先权日:2021-11-29 标 题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes 发明人:ÖNAY UÇAR EVREN; DEM RAYAK EREF; BERK BARKIN; YURTTA LEYLA; B LTEK N KALEL SEVDE NUR; AH N ZAFER 权利人:UNIV ISTANBUL MEDIPOL; ISTANBUL UNIV REKTORLUGU; ANADOLU UNIV 摘要:The invention is related to the synthesis of 8 pyrazolone derivative compounds and their activities on COX enzymes.
专利号:US-2009118296-A1 优先权日:2005-07-20 标 题:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase 发明人:BLACK CAMERON; DESCHENES DENIS; GAGNON MARC; LACHANCE NICOLAS; LEBLANC YVES; LEGER SERGE; LI CHUN SING; OBALLA RENATA M 权利人:MERCK FROSST CANADA LTD 摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and fatty liver disease.
专利号:US-7745456-B2 优先权日:2000-11-06 标题 :Synthesis and antimicrobial activity of novel dicationic “reversed amidinesâ€? 发明人:BOYKIN DAVID W; TIDWELL RICHARD R; WILSON W DAVID; PERFECT JOHN R; STEPHENS CHAD E 权利人:UNIV NORTH CAROLINA; UNIV DUKE; UNIV GEORGIA STATE RES FOUND 摘要:The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula n nin which R 1 , R 2 , R 3 and R 4 are each independently selected from the group consisting of H, alkyl, alkoxy, halide, and alkylhalide groups; R 5 is H, alkyl or aryl; R 6 is H, alkyl, aryl, or NR 7 R 8 , in which R 7 and R 8 are each independently selected from the group consisting of H, alkyl and aryl; and X is O, S or NR 9 , in which R 9 is H or alkyl, and to the use of such compounds.
专利号:WO-2023096623-A2 优先权日:2021-11-29 标题:Synthesis of pyrazolone derivative compounds and their effects on cox enzymes
专利号:US-2004235927-A1 优先权日:2000-11-06 标 题 :Synthesis and antimicrobial activity of novel dicationic 'reversed amidines'
专利号:US-7241795-B2 优先权日:2000-11-06 标题 :Synthesis and antimicrobial activity of novel dicationic “reversed amidinesâ€?