CAS: 68238-36-8; Sodium 2-((4-(Diethylamino)Phenyl)(4-(Diethyliminio)Cyclohexa-2,5-Dien-1-Ylidene)Methyl)Benzene-1,4-Disulfonate

专利信息

专利号:US-12180142-B1
优先权日:2024-02-22
标 题:Synthesis process for high purity isosulfan blue using flash chromatography in commercial plant scale
发明人：KAVURU VIMAL; PATI KAMALKISHORE
权利人:RISING PHARMA HOLDINGS INC
摘要:A composition including a N-[4-[[4-(diethyl amino) phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium sodium salt, where the N-4-4-(diethylamino)phenyl (2,5-disulfophenyl)methylene-2,5-cyclohexadien-1-ylidene-N-ethylethanaminium sodium salt is at least 90% of the weight of such composition. A method of making the composition by a process including sulphonating 2-chlorobenzaldehyde, treatment with sodium sulphite and subsequent basification, a condensation step, an oxidation step and a purification step comprising utilizing HPLC to monitor the sulphonating step, the treatment step, the condensation step, and/or the oxidation step, to determine when one or more reactions of such sulphonating step, treatment step, condensation step, and/or oxidation step are substantially complete and ending such one or more reactions on the basis of the HPLC monitoring. The purification step utilizes flash chromatography to obtain a high purity N-[4-[[4-(diethyl amino) phenyl](2,5-disulfophenyl)methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium sodium salt.

专利号:US-6673940-B1
优先权日:1999-01-08
标 题:Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
发明人：DERVAN PETER B; BAIRD ELDON E
权利人:CALIFORNIA INST OF TECHN
摘要:The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular units. At least one molecular unit of such a compound is a hydrogen bond donor or acceptor. The polymer portions are covalently linked to form a cycle. These compounds are capable of targeting specific nucleotide sequences in double-stranded nucleic acids, particularly double-stranded DNA. Accordingly, such compounds can be used to modulate, e.g., increase or decrease, the expression of one or more genes in vitro or in vivo.

专利号:EP-4361127-A2
优先权日:2020-04-10
标题 :Process for the synthesis of sulfonated triarylmethane compounds

专利号:US-6984734-B2
优先权日:2002-02-26
标 题 :Cyclo[n]pyrroles and methods thereto
发明人：SESSLER JONATHAN L; SEIDEL DANIEL; BOLZE FREDERIC R; KOEHLER THOMAS
权利人:UNIV TEXAS
摘要:The present invention provides an oxidative coupling procedure that allows efficient synthesis of novel cyclo[n]pyrrole macrocycles. Therefore, the present invention provides cyclo[n]pyrroles where n is 6, 7, 8, 9, 10, 11, or 12, and derivatives, multimers, isomers, and ion and neutral molecule complexes thereof as new compositions of matter. A protonated form of cyclo[n]pyrrole displays a gap of up to 700 nm between strong Soret and Q-like absorption bands in the electronic spectrum, demonstrating no significant ground state absorption in the visible portion of the electronic spectrum. Uses of cyclo[n]pyrroles as separation media, nonlinear optical materials, information storage media and infrared filters are provided.

专利号:EP-1144414-B1
优先权日:1999-01-08
标 题 :Compositions and methods relating to cyclic compounds that undergo nucleotide base pair-specific interactions with double-stranded nucleic acids
发明人：BAIRD ELDON E; DERVAN PETER B
权利人:CALIFORNIA INST OF TECHN
摘要:The design, synthesis, and use of cyclic compounds, including cyclic polyamides, is described. Such compounds comprise at least two polymer portions, one of which comprises at least three molecular units, and the other comprises at least four molecular units. At least one molecular unit of such a compound is a hydrogen bond donor or acceptor. The polymer portions are covalently linked to form a cycle. These compounds are capable of targeting specific nucleotide sequences in double-stranded nucleic acids, particularly double-stranded DNA. Accordingly, such compounds can be used to modulate, e.g., increase or decrease, the expression of one or more genes in vitro or in vivo.

专利号:FR-3109150-A1
优先权日:2020-04-10
标题 :Process for the synthesis of sulfonated triarylmethane compounds