CAS: 69360-26-5; 2-Cyanobenzenesulfonyl Chloride

上下游产品

CAS号81-07-2 糖精 | CAS号63216-04-6 2-(benzylthio)b... | CAS号128-09-6 N-氯代丁二酰亚胺 | CAS号100-51-6 苯甲醇 | CAS号2527-57-3 2,2-二硫代双苯甲酰胺 | CAS号1012-97-1 (1,1-dioxo-2H-1... | CAS号60-29-7 乙醚 | CAS号75-00-3 氯乙烷 | CAS号69360-20-9 1,1-dioxo-2-pro... | CAS号395-46-0 2-cyanobenzenes...

糖精置于五氯化磷体系中,化学反应生成 2-氰基苯磺酰氯
参考文献:Process For The Preparation Of 2-Fluorobenzonitrile From Saccharin
标题:Process For The Preparation Of 2-Fluorobenzonitrile From Saccharin
摘要:本发明涉及一种制备2-氟苯甲腈的方法.该方法包括以下步骤:(A)在足够条件和时间下加热糖精和五氯化磷,以提供2-氰基苯磺酰氯;(B)将2-氰基苯磺酰氯与碱金属氟化物在溶剂中反应,以在足够条件和时间下提供2-氟苯甲腈.本发明提供了一种制备2-氟苯甲腈的方法,该方法是各种2-氟取代苯的多功能中间体.例如,2-氟苯甲腈的水解会产生2-氟苯甲酸或2-氟苯甲酰胺,而2-氟苯甲腈的还原会产生2-氟苯甲胺.此外,2-氟苯甲腈与有机金属试剂的反应会产生各种2-氟苯基酮.

专利信息

专利号:US-2022363662-A1
优先权日:2021-04-20
标题 :Compounds as lxr agonists
发明人：PUJALA BRAHMAM; SATHE BALAJI DASHRATH; DANODIA ABHINANDAN; GUPTA ASHU; SONI SANJEEV; KUMAR VIVEK; ANSARI AMANTULLAH; KHAN FARHA; SARKAR ARINDAM; PAYGHAN PAVAN V
权利人:INTEGRAL BIOSCIENCES PRIVATED LTD
摘要:The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

专利号:US-2022315528-A1
优先权日:2019-08-21
标题:Inhibitors of phospholipid synthesis and methods of use
发明人：GOUW ARVIN; SCHOW STEVEN R; GREENHOUSE ROBERT J; KLINE TONI; FELSHER DEAN W
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome, hyperlipidemia, infection and inflammation.

专利号:CN-117720498-A
优先权日:2023-11-03
标 题 :Synthesis of a new coumarin derivative containing a sulfonamide fragment and preparation method and application of its composition

专利号:US-8163773-B2
优先权日:2005-07-11
标题 :Organic compounds
发明人：BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI
权利人:BREITENSTEIN WERNER; ERHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; MASUYA KEIICHI; KONISHI KAZUHIDE; YOKOKAWA FUMIAKI; KANAZAWA TAKANORI; JACOBY EDGAR; MARZINZIK ANDREAS; GROSCHE PHILIPP; KAWAKAMI SHIMPEI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. The preferred compounds (which can also be present as salts) have the formula I wherein R1, R2, T, R3 and R4 are as defined in the specification.

专利号:WO-2021035031-A1
优先权日:2019-08-21
标 题 :Inhibitors of phospholipid synthesis and methods of use

专利号:NO-318910-B1
优先权日:1998-12-23
标 题:Protease inhibitors, method of synthesis and use thereof, and pharmaceutical composition