CAS: 775304-57-9; 3-(5-(2-Fluorophenyl)-1,2,4-Oxadiazol-3-yl)Benzoic Acid

上下游产品

CAS号775304-60-4 3-(5-(2-氟苯基)-1,... | CAS号393-52-2 邻氟苯甲酰氯 | CAS号1141475-82-2 3-(N-hydroxycar...

3-(N'-((2-Fluorobenzoyl)Oxy)Carbamimidoyl)Benzoic Acid 以 叔丁醇 作为反应溶剂,化学反应 24.0H,以88.4%的收率获得产物3-[5-(2-氟苯基)-1,2,4-恶二唑-3-基]苯甲酸
参考文献:Process For Preparing Ataluren And Its Intermediates
标题:Process For Preparing Ataluren And Its Intermediates
摘要:本发明提供了制备阿塔卢伦的工艺.还提供了制备阿塔卢伦的中间体.

专利信息

专利号:US-8367841-B2
优先权日:2006-09-08
标 题 :Processes for the preparation of 1,2,4-oxadiazole benzoic acids
发明人：ALMSTEAD NEIL G; HWANG PETER SEONGWOO; PINES SEEMON; MOON YOUNG-CHOON; TAKASUGI JAMES J
权利人:PTC THERAPEUTICS INC; ALMSTEAD NEIL G; HWANG PETER SEONGWOO; PINES SEEMON; MOON YOUNG-CHOON; TAKASUGI JAMES J
摘要:Provided herein are processes for the preparation of compounds useful for the treatment, prevention or management of diseases associated with a nonsense mutation. More specifically, provided herein are processes for the synthesis of 1,2,4-oxadiazoles. In particular, provided herein are processes useful for the preparation of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid.

专利号:US-9470680-B2
优先权日:2011-02-28
标 题:Fluorescence-based approach to monitor release factor-catalyzed termination of protein synthesis
发明人：GONZALEZ JR RUBEN L; STERNBERG SAMUEL H; PULUKKUNAT DILEEP K
权利人:GONZALEZ JR RUBEN L; STERNBERG SAMUEL H; PULUKKUNAT DILEEP K; UNIV COLUMBIA
摘要:Provided are probes comprising a class 1 release factor conjugated to a fluorescent label and methods of making the probes. Also provided are methods for detecting conformational changes in ribosomes and associated molecules, such as class 1 release factors. In addition, methods of identifying a compound for reducing nonsense-mediated decay of mRNA and/or for inhibiting termination of protein synthesis at a premature stop codon, are described. Methods of assaying RF3 activity are also included.

专利号:WO-2024213057-A1
优先权日:2023-04-12
标题:Use of combination of lsd1 inhibitor and drug to treat cancer
发明人：LIU HONG; LI JIA; HUANG HE; WANG JIANG; ZHOU YUBO; REN XUELIAN; LI CHUNPU; KAN WEIJUAN; XU ZICHAO; HU XIAOBEI; WU HENGBO; WANG HANLIN; YE YUNFEI; QIU XIAOHUI; SU MINGBO
权利人:SHANGHAI INST MATERIA MEDICA CAS
摘要:A use of a combination of an LSD1 inhibitor and a drug to treat cancer. Specifically, provided is a composition comprising: a tranylcypromine compound and/or a derivative thereof; and a drug selected from a kinase inhibitor, an anti-cancer drug acting upon or affecting the DNA, an antiviral compound, an antihypertension compound, an antidiabetic compound, a JAK-STAT signaling pathway inhibitor, an NF-κB signaling pathway inhibitor, a protein synthesis inhibitor, a 5-hydroxytryptamine receptor agonist, a dystroglycan modulator, a GABA receptor modulator, or a combination thereof. The two active ingredients have a synergistic effect, and the synergistic treatment effect is significantly better than that of the two individually, thereby remarkably improving the cancer treatment effect.

专利号:US-8129540-B2
优先权日:2003-04-11
标题:Methods for the synthesis of 1,2,4-oxadiazole benzoic acid compounds

专利号:US-2010121070-A1
优先权日:2003-04-11
标 题 :Methods for the synthesis of 1,2,4-oxadiazole benzoic acid compounds

专利号:CN-106279057-B
优先权日:2016-08-15
标题:Synthesis of Ataluren