CAS: 869-10-3; Diethyl 2,5-Dibromohexanedioate

相似化合物

870-78-0 7209-00-9 615-83-8

上下游产品

CAS号124-04-9 己二酸 | CAS号111-50-2 己二酰氯 | CAS号64-17-5 乙醇 | CAS号1004-98-4 2,5-二氮杂双环[2.2.2... | CAS号3588-17-8 反式,反式-1,3-丁二烯-1... | CAS号13544-77-9 Hexaric acid,3,... | CAS号183318-53-8 2-Piperidinone,... | CAS号617-35-6 丙酮酸乙酯 | CAS号5515-83-3 乙醇合三氯乙醛 | CAS号17740-40-8 1-苄基-2,5-吡咯烷羧酸二乙酯

Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 2,5-二溴己二酸二乙酯
参考文献:Le Sueur,Journal Of The Chemical Society,1909,Vol. 95,P. 276
标题:Le Sueur,Journal Of The Chemical Society,1909,Vol. 95,P. 276

专利信息

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-7179794-B2
优先权日:1998-06-08
标题 :Multivalent macrolide antibiotics
发明人：GRIFFIN JOHN H; PACE JOHN L
权利人:THERAVANCE INC
摘要:Disclosed are multibinding compounds which include macrolide antibiotics, aminoglycosides, lincosamides, oxazolidinones, streptoramins, tetracycline and/or other compounds which bind to bacterial ribosomal RNA and/or to one or more proteins involved in ribosomal protein synthesis in the bacterium, which are useful in treating bacterial infections. The compounds adversely affect protein expression and have an antibacterial effect. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is macrolide antibiotic, aminoglycoside, lincosamide, oxazolidinone, streptogramin, tetracycline or other compound which binds to bacterial ribosomal RNA and/or one or more proteins involved in ribosomal protein synthesis in the bacterium.