CAS: 88150-75-8; Ethyl 4-(2-(1,3-Dioxoisoindolin-2-yl)Ethoxy)-3-Oxobutanoate

上下游产品

CAS号3891-07-4 N-羟乙基酞酰亚胺 | CAS号638-07-3 4-氯乙酰乙酸乙酯 | CAS号88150-42-9 氨氯地平 | CAS号88150-62-3 邻苯二甲酰基氨氯地平

2-(2-苯二甲酰亚胺已氧基)乙酸置于草酰氯,三正丁胺体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 4.0H,反应生成 乙基-4-(2-邻苯二甲酰亚胺基乙氧基)乙酰乙酸乙酯
参考文献:一种氨氯地平中间体的制备方法
标题:一种氨氯地平中间体的制备方法
摘要:本发明提供了一种氨氯地平中间体的制备方法,属于原料药合成技术领域.本发明将化合物1(2‑(2‑(2‑羟基乙氧基)乙基)异吲哚啉‑1,3‑二酮),N‑o自由基催化剂,金属盐催化剂和第一有机溶剂混合,在氧化剂作用下进行氧化反应,得到化合物2;所述氧化剂为空气或氧气;将化合物2,酰氯化试剂和第二有机溶剂混合,进行酰氯化反应,得到化合物3;将化合物3,丙二酸单甲酯单钾盐,叔胺和第三有机溶剂混合,进行c‑酰基化反应,得到氨氯地平中间体.本发明提供的方法原料价廉易得,三废污染少,工艺安全性高,操作简便,易于工业化生产.

专利信息

专利号:US-6603006-B2
优先权日:1998-10-26
标题:Intermediate for the synthesis of amlodipine, a process for the preparation thereof and corresponding use
发明人：COPPI LAURA; GASANZ GUILLEN YOLANDA; CAMPON PARDO JULIO
权利人:ESTEVE QUIMICA SA
摘要:An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed. The intermediate is ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and is of formula III:The process for the preparation thereof comprises reacting the acetoacetate of formula:with ammonium acetate; and the use thereof is for the preparation of the compound of formula:the process being conducted by reacting ethyl 3-amino-4-[2-(phthalimido)ethoxy]crotonate with a benzylidene derivative.

专利号:WO-2004058711-A1
优先权日:2002-12-30
标 题 :Isolation of dihydropyridine derivative and preparation salts thereof
发明人：ASLAN TUNCER; ADIYAMAN MUSTAFA; YURDAKUL AYCIL; SAHPAZ FILIZ; OZARSLAN EVREN A; GUNER DIDEM; RIDVANOGLU NURTEN
权利人:EOS ECZACIBASI OZGUN KIMYASAL; ASLAN TUNCER; ADIYAMAN MUSTAFA; YURDAKUL AYCIL; SAHPAZ FILIZ; OZARSLAN EVREN A; GUNER DIDEM; RIDVANOGLU NURTEN
摘要:The title compound is isolated in pure form by using a crystallization process and converted to its pharmaceutically acceptable salts. The crystallization process affects stability and purity of the amlodipine salts. All known impurities and one unknown impurity, which forms during the synthesis of the amlodipine salts, were isolated, characterized, and synthesized. A new method allowing the quantitative HPLC analysis of all related impurities of amlodipine salts in a single chromatogram was developed.

专利号:DE-69929079-T2
优先权日:1998-10-26
标题:INTERMEDIATE FOR THE SYNTHESIS OF AMLODIPIN, METHOD OF MANUFACTURE AND CORRESPONDING APPLICATION

专利号:EP-1125924-B1
优先权日:1998-10-26
标题:Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization

专利号:US-2002068831-A1
优先权日:1998-10-26
标 题 :Intermediate for the synthesis of amlodipine, a process for the preparation there and corresponding use

专利号:AU-6477299-A
优先权日:1998-10-26
标题 :Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization