CAS: 1011-65-0; Methyl 1H-Indole-5-Carboxylate

相似化合物

1196-69-6 1670-81-1 1075-25-8

上下游产品

吲哚-5-羧酸 1H-Indole-5-Carboxylic Acid 1670-81-1
吲哚-5-甲醇 Indole-5-Methanol 1075-25-8
5-吲哚甲醛 1H-Indole-5-Carboxaldehyde 1196-69-6
6-吲哚甲酸 Indole-6-Carboxylic Acid 1670-82-2
5-氰基吲哚 1H-Indole-5-Carbonitrile 15861-24-2

5-碘吲哚置于3,4-Benzo-1,1,2,2-Tetraethyl-1,2-Disilacyclobutene,Cesium Fluoride体系中,用 乙醚,N,N-二甲基甲酰胺 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 2.17H,反应生成吲哚-5-甲酸甲酯
参考文献:A Strained Disilane-Promoted Carboxylation Of Organic Halides With Co2 Under Transition-Metal-Free Conditions
标题:A Strained Disilane-Promoted Carboxylation Of Organic Halides With Co2 Under Transition-Metal-Free Conditions
摘要:By Using A Strained Four-Membered Ring Disilane (3,4-Benzo-1,1,2,2-Tetraethyldisilacyclobutene) And Csf,A Wide Range Of Aryl,Alkenyl,Alkynyl,Benzyl,Allyl,And Alkyl Halides Was Successfully Carboxylated Under An Ambient Co2 Atmosphere (Co2 Balloon) At Room Temperature Within 2 H. In This Carboxylation,A Highly Reactive Silyl Anion,Which Is Generated From The Disilane And Csf,Is A Key To Facilitating The Formation Of A Carbanion Equivalent. The Resulting Anionic Species Can Be Trapped With Co2 To Produce Carboxylic Acids With High Efficiency.
Doi:10.1021/acs.Orglett.5B02645

专利信息

专利号:US-4841045-A
优先权日:1985-03-12
标 题 :Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-4897477-A
优先权日:1985-03-12
标题:Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:WO-8605491-A1
优先权日:1985-03-12
标 题 :Synthesis of vinblastine and vincristine type compounds