CAS: 10210-17-0; 3-(4-Hydroxyphenyl)-1-Propanol

该化合物是一种酚醇衍生物,可用于有机合成和制药中间体,其氢氧基和丙醇功能组为进一步的化学改造提供了多种功能.该化合物在标准条件下具有稳定性,并可用于生产细化学物质,香味和生物活性分子.适合需要精确的苯性反应的受控反应.

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上下游产品

3-(p-methoxyphenyl)-1-propanol methyl 3-(4-acetyloxyphenyl)propanoate 3-(4-hydroxyphenyl)propanoic acid amide 4-(3-chloropropyl)phenol 4-[3-(2-Nitro-phenylselanyl)-propyl]-phenol 4-(3-hydroxypropyl)phenyl acetate 4-(3-bromopropyl)phenol 3-(4-acetoxyphenyl)propyl acetate

合成工艺路线路线简述

    对羟基苯丙酸置于sodium Hydroxide,锂硼氢,Potassium Carbonate体系中,用 四氢呋喃,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 45.0H,反应生成3-(4-羟基苯基)-1-丙醇
    参考文献:Diels-Alder Cycloadditions 到交叉共轭环己二烯酮期间 Oxaspiro 环的立体选择性控制:合成氧现象
    标题:Diels-Alder Cycloadditions 到交叉共轭环己二烯酮期间 Oxaspiro 环的立体选择性控制:合成氧现象
    摘要:研发了在涉及具有不同反应性的二烯的螺环交叉共轭环己二烯酮的 Diels-Alder 加成中操作的非对映面选择性.该研究包括醚系列 1A-C 以及内酯/酮对 2A/2B.在所有情况下,优选的 [4+2] 环加成途径由从 Pi 表面顺式键合到氧原子组成.4-取代的-4-甲基-2,5-环己二烯酮(单环系统)也进行了检查,发现它们优先从带有两个基团在4位吸电子更多的表面形成键.确定了 1A 和 2A 环加成生成环戊二烯的动力学参数.溶剂的速率加速曲线的顺序为 Cf(3)Ch(2)Oh >> Ch(3)Cn 大约 Ch(2)Cl(2) 用于从 1A 生产 9A 和 Cf(3)Ch(2)Oh >> Ch(2)Cl(2) > Ch(3)Cn 用于生产21A 分别来自 2A.这种极性分布对产品分布没有重大影响,这一现象也反映在 4-取代-4-甲基-2,5-环己二烯酮在可比条件下的行为中.这些实验事实的理论评估是在
    Doi:10.1021/ja047027T

    海关参考信息

    专利信息


    专利号:WO-2012152438-A1
    优先权日:2011-05-11
    标题 :Process for the preparation of nitrate acid ester of organic compounds
    发明人:BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL
    权利人:NICOX SA; BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL
    摘要:The present invention relates to a one-step process for the synthesis of nitric acid esters or 15 N isotopically labeled nitrate esters of organic compounds starting from the correspondent alcohols. Formula (I).

    专利号:WO-2010068944-A2
    优先权日:2008-12-12
    标题:Biological synthesis of difunctional alkanes from carbohydrate feedstocks

    专利号:US-11553715-B2
    优先权日:2019-07-08
    标题:Synthesis and formulation of lignin derived compounds as treatment of plant diseases
    发明人:SHI JIAN; KALINOSKI RYAN M
    权利人:UNIV KENTUCKY RES FOUND
    摘要:The present invention relates to a methods for producing bio-oils from vegetation high in lignin. The invention further relates to antimicrobial compositions comprising bio-oil extracted from vegetation high in lignin.

    专利号:US-9751844-B2
    优先权日:2010-12-14
    标 题 :Precursor compound connected to solid support for manufacturing 18F radiopharmaceutical, method for manufacturing same, and application thereof
    发明人:CHI DAE-YOON; LEE BYOUNG-SE; LEE JAE-HAK; CHU SO-YOUNG; JUNG WOON-JUNG; KWON HYE-RIM
    权利人:CHI DAE-YOON; LEE BYOUNG-SE; LEE JAE-HAK; CHU SO-YOUNG; JUNG WOON-JUNG; KWON HYE-RIM; FUTURECHEM CO LTD
    摘要:The present invention relates to a solid precursor in the form of an organic salt, the solid precursor having a solid support, a method for manufacturing same, and an application thereof. The solid precursor of the present invention enables omission of the [ 18 F]fluoride refining process using additional cartridge, and the use of excessive phase-transfer catalyst, and can easily remove remaining substance after reaction through the solid support inside the precursor. The solid precursor of the present invention is very appropriate for an automated synthesis device as an all-in-one system that can carry out overall process of [ 18 F]fluorosis reaction, when used by charging in a cartridge.

    专利号:UA-77527-C2
    优先权日:2002-06-20
    标题:Benzoic acid derivatives as modulators of ppar alpha and ppar gamma, method of synthesis, pharmaceutical composition, intermediate

    专利号:CN-109988213-B
    优先权日:2017-12-29
    标 题:A kind of compound for polypeptide liquid phase synthesis carrier and preparation method and use thereof
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    合成参考文献


    摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 75.
    摘要:Zimmer, R.; Trawny, D., Science of Synthesis Knowledge Updates, (2013) 4, 161.
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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