CAS: 169624-67-3; Fmoc-Phe-Gly

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N-[(1S)-2-氯-2-氧代-1-(苯甲基)乙基]-氨基甲酸-9H-芴-9-甲酯置于水,Calcium Chloride,Sodium Hydroxide,锌体系中,用 四氢呋喃,异丙醇 用作溶剂,化学反应生成N-芴甲氧羰基-苯丙氨酰-甘氨酸
参考文献:电喷雾电离串联质谱(esi-Ms(n))表征nα-Fmoc保护的二肽异构体:保护基对二肽断裂的影响.
标题:电喷雾电离串联质谱(esi-Ms(n))表征nα-Fmoc保护的二肽异构体:保护基对二肽断裂的影响.
摘要:Fmoc保护的二肽,Fmoc-Gly-Xxx-Oy / Fmoc-Xxx-Gly-Oy(xxx = Ala,Val,Leu,Phe)和fmoc-Ala-Xxx-Oy / Fmoc-Xxx的一系列位置异构对-Ala-Oy(xxx = Leu,Phe)(fmoc = [(9-芴基甲基)氧基]羰基和y = Ch(3)/ H)的特征在于,正离子和负离子电喷雾电离离子-阱串联质谱(esi-It-Ms(n)).与主要产生y(1)(+)和/或a(1)(+)离子的未保护二肽异构体的行为相反,质子化的fmoc-Xxx-Gly-Oy,Fmoc-Ala-Xxx-Oy和fmoc-Xxx-Ala-Oy产生明显的b(1)(+)离子.形成这些离子,大概具有稳定的质子化叠氮醌结构.但是,在n端带有gly-的肽不会形成b(1)(+)离子.所有肽的[m + H](+)离子都会经历mclafferty型重排,然后损失co(2)形成[m
Doi:10.1002/rcm.5076

专利信息

专利号:US-2024124517-A1
优先权日:2020-12-25
标题:Method for producing peptide compound containing n-substituted-amino acid residue
发明人：MORITA YUYA; NOMURA KENICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a method for efficiently producing a high-purity peptide compound with a high yield. It has been found that the object can be achieved by supporting a peptide on a solid phase synthesis resin prior to a first elongation reaction in a solid phase process.