CAS: 183288-46-2; 5-(Piperazin-1-yl)Benzofuran-2-Carboxamide

相似化合物

913730-87-7 183288-44-0 183288-47-3

上下游产品

CAS号183288-44-0 4-(2-氨基甲酰基苯并呋喃-... | CAS号267644-49-5 2-氨基羰基-5-硝基苯并呋喃 | CAS号6280-80-4 2-甲酰苯氧乙酸 | CAS号90-02-8 水杨醛 | CAS号6965-69-1 2-(2-甲酰基-4-硝基苯氧基)乙酸 | CAS号10242-12-3 5-硝基苯并呋喃-2-甲酸 | CAS号1646-29-3 5-氨基苯并呋喃-2-羧酸甲酯 | CAS号163521-12-8 维拉佐酮

2-甲酰苯氧乙酸置于氯化亚砜,硫酸,氨,氢溴酸,氢气,乙酸酐,溶剂黄146,N,N-二异丙基乙胺,对羟基苯甲酸体系中,用 甲醇,水,N,N-二甲基甲酰胺,甲苯 用作溶剂,5.0~125.0 °C,600.01 Kpa 条件下,反应 38.25H,反应生成5-(哌嗪-1-基)苯并呋喃-2-甲酰胺
参考文献:Polymorphic Form Of 5-(4-[4-(5-Cyano-1H-Indol-3-yl) Butyl] Piperazin-1-yl) Benzofuran-2-Carboxamide And Process For Preparing Thereof
标题:Polymorphic Form Of 5-(4-[4-(5-Cyano-1H-Indol-3-yl) Butyl] Piperazin-1-yl) Benzofuran-2-Carboxamide And Process For Preparing Thereof
摘要:本发明提供了5-(4-[4-(5-氰基-1H-吲哚-3-基)丁基]哌嗪-1-基)苯并呋喃-2-羧酰胺的固态z型.本发明还提供了一种制备5-(4-[4-(5-氰基-1H-吲哚-3-基)丁基]哌嗪-1-基)苯并呋喃-2-羧酰胺的z型的方法,包括以下步骤:I) 在有机溶剂中,在碱的存在下,将5-(1-哌嗪基)苯并呋喃-2-羧酰胺或其盐的固态形式与3-(4-氯丁基)-1H-吲哚-5-羧腈反应,以获得粗制维拉唑酮游离碱;Ii) 在有机溶剂中纯化步骤(I)中的粗制维拉唑酮游离碱;Iii) 用有机溶剂处理步骤(II)中的纯化维拉唑酮游离碱,以获得维拉唑酮的固态z型.本发明还提供了一种包含维拉唑酮盐酸盐无定形形式的治疗有效量的药物组合物,以及使用维拉唑酮的固态z型治疗重度抑郁症.

专利信息

专利号:WO-2016170542-A1
优先权日:2015-04-23
标题:Process for preparation of vilazodone, novel intermediates thereof and novel crystalline form thereof
发明人：BHEMIREDDY SATYANARAYANA REDDY; YARAPATHI VENKAT REDDY; PAIDIMARLA V VARA PRASADA REDDY
权利人:NOSCH LABS PRIVATE LTD
摘要:The invention relates to process for preparation of Vilazodone and novel intermediates for synthesis of Vilazodone. The invention also relates to novel crystalline form of Vilazodone hydrochloride and process for preparation thereof.

专利号:US-2014275542-A1
优先权日:2013-03-15
标 题 :Synthesis of a serotonin reuptake inhibitor
发明人：TADDEI MAURIZIO; GIANNOTTI LUCA; ATTOLINO EMANUELE; ALLEGRINI PIETRO
权利人:DIPHARMA FRANCIS SRL
摘要:Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults.

专利号:US-5977112-A
优先权日:1995-04-20
标 题:Process of making substituted benzofurans
发明人：BATHE ANDREAS; HELFERT BERND; BOTTCHER HENNING; SCHUSTER KURT
权利人:MERCK PATENT GMBH
摘要:Benzofurans of the formula I ##STR1## and their salts in which R 1 , R 2 and X have the meanings indicated in claim 1, are suitable as intermediates in the synthesis of medicaments and show effects on the central nervous system.

专利号:WO-2016142952-A1
优先权日:2015-03-10
标 题:Process for preparation of vilazodone and its novel intermediates
发明人：BHEMIREDDY SATYANARAYANA REDDY; YARAPATHI VENKAT REDDY; PAIDIMARLA V VARA PRASADA REDDY
权利人:NOSCH LABS PRIVATE LTD
摘要:The invention relates to process for preparation of Vilazodone and novel intermediates for synthesis of Vilazodone.

专利号:US-6531503-B1
优先权日:1999-07-10
标 题 :Benzofurane derivatives
发明人：BATHE ANDREAS; HELFERT BERND; BOETTCHER HENNING
权利人:MERCK PATENT GMBH
摘要:Benzofurane derivatives of formula (I), wherein R and R' have the meanings given in claim no. (1), and salts thereof are suitable for use as intermediate products in the synthesis of medicaments.

专利号:EP-2778165-A1
优先权日:2013-03-15
标 题 :Synthesis of a serotonin reuptake inhibitor