CAS: 56908-88-4; 1,3-Dibromo-5-(Bromomethyl)Benzene

上下游产品

CAS号145691-59-4 3,5-二溴苯甲醇 | CAS号1611-92-3 3,5-二溴甲苯 | CAS号56990-02-4 3,5-二溴苯甲醛 | CAS号188347-48-0 3,5-二溴苯乙腈 | CAS号188347-49-1 3,5-二溴苯乙酸 | CAS号145691-59-4 3,5-二溴苯甲醇

3,5-二溴苯甲醇置于n-溴代丁二酰亚胺(Nbs),双(三甲基硅烷基)氨基钾,1,3,4-三苯基-4,5-二氢-1H-1,2,4-三氮唑-5-亚基体系中,用 二氯甲烷 作为反应溶剂,化学反应 6.0H,以174 Mg的收率获得产物3,5-二溴苄基溴
参考文献:N-杂环卡宾对appel型反应的促进作用†
标题:N-杂环卡宾对appel型反应的促进作用†
摘要:N-杂环卡宾(nhc)已广泛用作有机催化和有机金属化学中的一类通用催化剂和配体.但是,只有少数几种合成应用程序充当试剂.在这里,我们证明了nhc可用作化学计量的氧化还原试剂,用于醇的appel型卤化反应.这种新的反应性揭示了一个新鲜有趣的方面,并丰富了未开发区域中nhc的化学性质.还研究了使用nhc-氧化物衍生物在催化水平上进行此化学转化的潜力.
DOI:10.1039/c9Cc02132A

专利信息

专利号:US-7189864-B2
优先权日:1990-11-19
标 题:Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:US-6022996-A
优先权日:1990-11-19
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.

专利号:EP-0641333-B1
优先权日:1992-05-20
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P
权利人:SEARLE & CO; MONSANTO CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide compound of formula (I) from a chiral alpha amino aldehyde and halomethyllithium as an organometallic methylene-adding reagent. In formula (I) R<1> is selected from alkyl, aryl, cycloalkyl, cycloalkylalkyl and arylalkyl, which are optionally substituted with a group selected from alkyl, halogen, NO2, OR<9> or SR<9>, where R<9> represents hydrogen or alkyl; and P<1> and P<2> independently are selected from amine protecting groups, including but not limited to, arylalkyl, substituted arylalkyl, cycloalkenylalkyl and substituted cycloalkenylalkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl and silyl.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-8101665-B2
优先权日:2007-12-17
标题 :Process for synthesis of tritiated and deuterated thiorphan and acetorphan
发明人：MASJEDIZADEH MOHAMMAND R; WU SHAO-YONG
权利人:MASJEDIZADEH MOHAMMAND R; WU SHAO-YONG; ROCHE PALO ALTO LLC
摘要:Methods for preparing tritium or deuterium labeled thiorphan comprising reacting a compound of formula j n nwherein m is from 1 to 5 and X is halo, with Z 2 wherein Z is tritium or deuterium, in the presence of a catalyst, to form a compound of formula kn n nwherein n is from 1 to 5, provided that n is less than or equal to m.

专利号:US-2002161234-A1
优先权日:1990-11-19
标 题 :Method of preparing intermediates useful in synthesis of retroviral protease inhibitors