CAS: 59782-85-3; 2,5-Dichloronicotinic Acid

相似化合物

67754-03-4 126954-66-3 176433-49-1

上下游产品

CAS号2402-78-0 2,6-二氯吡啶 | CAS号138006-41-4 2,5-二氯-3-溴吡啶 | CAS号38076-80-1 5-氯-2-羟基烟酸 | CAS号609-71-2 2-羟基烟酸 | CAS号78686-87-0 2,5-二氯吡啶-3-羰酰氯 | CAS号67754-03-4 2,5-二氯烟酸甲酯 | CAS号148065-10-5 2,5-二氯烟酸乙酯

2,6-二氯吡啶置于正丁基锂,二异丙胺体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.17H,反应生成 2,5-二氯烟酸
参考文献:Ep1364950
标题:Ep1364950

专利信息

专利号:US-5854257-A
优先权日:1994-10-06
标 题:Naphthyridinone derivatives
发明人：ARMITAGE BERNARD JOHN; LESLIE BRUCE WILLIAM
权利人:KNOLL AG
摘要:PCT No. PCT/EP95/03808 Sec. 371 Date Mar. 24, 1997 Sec. 102(e) Date Mar. 24, 1997 PCT Filed Sep. 26, 1995 PCT Pub. No. WO96/11199 PCT Pub. Date Apr. 18, 1996Compounds of formula I I including pharmaceutically acceptable salts thereof in which R1 represents a phenyl C1-6 alkyl group (in which the phenyl ring is optionally substituted by one or more of the following: halo, a C1-4 alkyl group, a C1-4 alkoxy group, hydroxy or trifluoromethyl) and the alkyl chain is optionally substituted by one or more C1-2 alkyl groups; R2 represents a C2-6 alkoxycarbonyl group; and R3 represents hydrogen or halo are disclosed, which are antirheumatic agents and are useful as modulators of cytokine synthesis, immunomodulatory agents, antiinflammatory agents and anti-allergic agents. Compositions containing these compounds and processes to make these compounds are also disclosed.