CAS: 748805-87-0; (2-Amino-4,5-Difluorophenyl)Methanol

上下游产品

2-amino-4,5-difluorobenzoic acid

2-氨基-4,5-二氟苯甲酸置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 (2-氨基-4,5-二氟苯基)甲醇
参考文献:膦催化的β'-乙酰氧基联烯酸酯的[5+1]环化:直接获得四氢喹啉衍生物
标题:膦催化的β'-乙酰氧基联烯酸酯的[5+1]环化:直接获得四氢喹啉衍生物
摘要:开发了一种前所未有的膦催化 β'-乙酰氧基联烯酸酯与 1,5-二亲核试剂的 [5+1] 成环反应,这为在 Pph 3和 K 3存在下以非常好到高产率获得功能化四氢喹啉提供了新颖且简便的方法po 4在温和的反应条件下.值得注意的是,这是首次报道 β'-乙酰氧基联烯酸酯在路易斯碱催化的成环反应中充当 C1 合成子.
DOI:10.1039/d3Cc03413E

专利信息

专利号:US-8455479-B2
优先权日:2008-01-24
标 题 :Heterocyclic compounds
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; SINGH NISHAN; NANDA GURMEET KAUR; MAGADI SITARAM KUMAR; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; SINGH NISHAN; NANDA GURMEET KAUR; MAGADI SITARAM KUMAR; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more conditions that may be regulated or normalized via inhibition of dipeptidyl peptidase IV (DPP-IV).