CAS: 84478-75-1; 2-Chloro-4-Fluoro-5-Nitrophenol

该化合物是一种有机化合物,其特点是存在一种以氯,氟和硝基组物替代的酚环,其分子结构具有附于苯环的氢氧基(-OH),该物质在2,4和5个位置分别被氯原子,氟原子和硝基亚基(-NO2)进一步取代,该化合物一般在室温下是固体,可能呈现黄色至褐色,因其在各个领域,包括制药和农用化学物的潜在用途,因为它具有回活动性,并且有能力参与电药替代反应,因此众所周知,该物质的存在增强了其电阻特性,影响其酸性和再活性,此外,2-氯-4-氟-5-硝基诺磷醇可能具有具体的环境和安全考虑,需要按照监管准则谨慎处理和处置.

英文名称2-Chloro-4-Fluoro-5-Nitrophenol
中文名称2-氯-4-氟-5-硝基苯酚
IUPAC名称2-chloro-4-fluoro-5-nitrophenol
其它别名2-氯-4-氟-5-硝基苯酚(易制爆,甄准不供应); 4-Chloro-2-Fluoro-5-Hydroxynitrobenzene
CAS编号84478-75-1
MFCD编号:MFCD02670258
EINECS号:671-719-0
分子式:C6H3ClFNO3
分子量:191.54
产品CID: 1833240
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: NAWVMCKMQMJQMF-UHFFFAOYSA-N
InChI=1S/C6H3ClFNO3/c7-3-1-4(8)5(9(11)12)2-6(3)10/h1-2,10H…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别3(经口)
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H301 |吞咽会中毒.
防范说明P261-P264-P270-P272-P273-P280-P302+P352-P330-P391-P501
危险等级9
UN编号3077.0
危险品标志Xi
包装等级Ⅲ
安全声明26-36/37/39
危险类别码36/37/38

欧盟法规

ECHA物质C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 2-Chloro-4-Fluoro-5-Nitrophenol 主要起始原料 2-Chloro-4-Fluoro-5-Nitrophenyl Ethyl Carbonate
153471-75-1 = 84478-75-1
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water
标题:Synthesis Of Herbicide Flumiclorac-Pentyl
作者:Wu,Hao; Et Al
参考文献:Nongyao 日期:2000 卷标:39(11)]

1996-41-4 = 84478-75-1 [标题:Reaction Conditions
标题:Tetrahydrophthalimides,And Their Use
参考文献:European Patent Organization]

371-41-5 = 84478-75-1
反应条件:1.1 Reagents: Chlorine Solvents: 1,2-Dichloroethane; 3 - 4 H,5 - 10 °C1.2 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: Water; 20 - 30 °C1.3 Reagents: Phosgene Solvents: 1,2-Dichloroethane; 3 H,20 - 30 °C; 1 H,20 - 30 °C1.4 Reagents: Sulfuric Acid,Fuming Nitric Acid Solvents: Water; 1 H,40 - 60 °C; 60 °C -> 80 °C; 3 H,75 - 80 °C1.5 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 4 H,Reflux; Reflux -> 10 °C
标题:Synthesis Of 2-[2-Chloro-4-Fluoro-5-(1,3,4,5,6,7-Hexahydro-1,3-Dioxo-2H-Isoindol-2-Yl)Phenoxy]Acetic Acid Pentyl Ester (Flumiclorac-Pentyl)
作者:Zhang,Liyong; Et Al
参考文献:Nongyao 日期:2007 卷标:46(5) 页码:307-309]

371-41-5 = 84478-75-1
反应条件:1.1 Reagents: Chlorine1.2 Reagents: Sodium Hydroxide Solvents: Water1.3 Reagents: Sulfuric Acid,Nitric Acid2.1 Reagents: Sodium Hydroxide Solvents: Water
标题:Synthesis Of Herbicide Flumiclorac-Pentyl
作者:Wu,Hao; Et Al
参考文献:Nongyao 日期:2000 卷标:39(11)]

84478-88-6 = 84478-75-1
反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; Rt -> 5 °C; < 15 °C; 1 H,0 - 10 °C1.2 Solvents: Water; < 25 °C; 1 H,0 - 10 °C2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 10 Min,20 - 40 °C; 1.5 H,30 - 40 °C
标题:Development Of A Scalable Synthesis Of A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor: Efficient Construction Of A 6-Etherified [1,2,4]Triazolo[1,5-A]Pyridine-2-Amine Core
作者:Ishimoto,Kazuhisa; Et Al
参考文献:Organic Process Research & Development 日期:2014 卷标:18(1) 页码:122-134]

1996-41-4 = 84478-75-1
反应条件:1.1 Reagents: Sodium Carbonate Solvents: Water; Rt -> 45 °C; 1 H,45 °C; 45 °C -> 10 °C1.2 10 - 25 °C2.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; Rt -> 5 °C; < 15 °C; 1 H,0 - 10 °C2.2 Solvents: Water; < 25 °C; 1 H,0 - 10 °C3.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 10 Min,20 - 40 °C; 1.5 H,30 - 40 °C
标题:Development Of A Scalable Synthesis Of A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor: Efficient Construction Of A 6-Etherified [1,2,4]Triazolo[1,5-A]Pyridine-2-Amine Core
作者:Ishimoto,Kazuhisa; Et Al
参考文献:Organic Process Research & Development 日期:2014 卷标:18(1) 页码:122-134]

1996-41-4 = 84478-75-1
反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: 1,2-Dichloroethane,Water; 6 - 80 °C1.2 Reagents: Triphosgene Solvents: 1,2-Dichloroethane; 6 - 80 °C1.3 Reagents: Sulfuric Acid,Fuming Nitric Acid Solvents: Water; 4 - 5 H,80 °C1.4 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 4 H,Reflux; Reflux -> 10 °C
标题:Synthesis Of Novel Herbicide Flumiclorac-Pentyl
作者:Lu,Yang; Et Al
参考文献:Nongyao Kexue Yu Guanli 日期:2009 卷标:30(6) 页码:33-35]

371-41-5 = 84478-75-1
反应条件:1.1 Reagents: Chlorine Solvents: 1,2-Dichloroethane; 6 - 8 °C1.2 Reagents: Sodium Hydroxide,Triphosgene Catalysts: Tetrabutylammonium Bromide Solvents: 1,2-Dichloroethane,Water; 6 - 8 °C1.3 Reagents: Sulfuric Acid,Fuming Nitric Acid Solvents: Water; Rt; Rt -> 80 °C; 4 - 5 H,80 °C1.4 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 4 H,Reflux; Reflux -> 10 °C
标题:Synthesis Of Novel Herbicide Flumiclorac-Pintyl
作者:Lu,Yang; Et Al
参考文献:Huagong Jishu Yu Kaifa 日期:2009 卷标:38(6) 页码:14-16]

371-41-5 = 84478-75-1
反应条件:1.1 Reagents: Chlorine Solvents: 1,2-Dichloroethane; 6 - 8 °C2.1 Reagents: Sodium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: 1,2-Dichloroethane,Water; 6 - 80 °C2.2 Reagents: Triphosgene Solvents: 1,2-Dichloroethane; 6 - 80 °C2.3 Reagents: Sulfuric Acid,Fuming Nitric Acid Solvents: Water; 4 - 5 H,80 °C2.4 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 4 H,Reflux; Reflux -> 10 °C
标题:Synthesis Of Novel Herbicide Flumiclorac-Pentyl
作者:Lu,Yang; Et Al
参考文献:Nongyao Kexue Yu Guanli 日期:2009 卷标:30(6) 页码:33-35]

2378163-38-1 = 84478-75-1
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Ethanol; Rt
标题:Synthesis And Activity Investigation Of Novel 1H-Purin-6(9H)-One And 3H-Imidazo[4,5-D][1,2,3]Triazin-4(7H)-One Derivatives
作者:Liu,Weijie; Et Al
参考文献:Acs Omega 日期:2019 卷标:4(13) 页码:15742-15753]

2378163-37-0 = 84478-75-1
反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; -5 °C -> 0 °C2.1 Reagents: Sodium Hydroxide Solvents: Ethanol; Rt
标题:Synthesis And Activity Investigation Of Novel 1H-Purin-6(9H)-One And 3H-Imidazo[4,5-D][1,2,3]Triazin-4(7H)-One Derivatives
作者:Liu,Weijie; Et Al
参考文献:Acs Omega 日期:2019 卷标:4(13) 页码:15742-15753]

1996-41-4 = 84478-75-1
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; -5 °C -> 0 °C2.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; -5 °C -> 0 °C3.1 Reagents: Sodium Hydroxide Solvents: Ethanol; Rt
标题:Synthesis And Activity Investigation Of Novel 1H-Purin-6(9H)-One And 3H-Imidazo[4,5-D][1,2,3]Triazin-4(7H)-One Derivatives
作者:Liu,Weijie; Et Al
参考文献:Acs Omega 日期:2019 卷标:4(13) 页码:15742-15753

(2-Chloro-4-Fluorophenyl) Ethyl Carbonate置于硫酸,水,硝酸,碳酸氢钠体系中,用甲醇作为反应溶剂,化学反应 18.0H,反应生成 2-氯-4-氟-5-硝基苯酚
参考文献:Wo2008/133753
标题:Wo2008/133753

海关参考信息

2903919090-氯苯
2908991010-4-硝基苯酚
2908199090-其他酚的卤化衍生物
2918290000-其他含酚基羧酸
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4560752-A
优先权日:1984-03-02
标题:Phosphinates or phosphonates useful for control of weeds
发明人：LEE SHY-FUH
权利人:ZOECON CORP
摘要:Novel 5-(substituted amino)phenoxyalkyl-, phenylthioalkyl-, phenylsulfinylalkyl-, and phenylsulfonylalkylphosphinates and phosphonates, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.

专利号:US-4613675-A
优先权日:1984-11-30
标题 :Phosphorus containing 1-cyclohexene-1,2-dicarboxamides
发明人：LEE SHY-FUH
权利人:SANDOZ LTD
摘要:Substituted 1-cyclohexene-1,2-dicarboxamides, synthesis thereof, intermediates therefor, and the use of said compounds for the control of weeds.

专利号:RU-2038351-C1
优先权日:1990-07-17
标题 :Benzene derivatives containing heterocycle, methods of their synthesis, and herbicide agent