CAS: 84994-24-1; Benzo[d]Thiazol-2-Yl (Z)-2-(2-Aminothiazol-4-yl)-2-(Methoxyimino)Acetate

专利信息

专利号:US-5574155-A
优先权日:1992-02-20
标 题 :Process for the synthesis of the disodium salt hemiheptahydrate of ceftriaxone
发明人：DANKLMAIER JOHANN; MACHER INGOLF; PRAGER BERNHARD
权利人:BIOCHEMIE GMBH
摘要:The invention relates to a new process for the production of the disodium salt hemiheptahydrate of ceftriaxone by reacting 7-amino-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-1,2,4-triazin-3-yl)thio]methyl}-3-cephem-4-carboxylic acid with 2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetic acid-(2-benzthiazolyl)thiolester in the presence of a base, characterized in that the reaction and the crystallization of the disodium salt hemiheptahydrate of ceftriaxone are carried out in aqueous acetone.

专利号:US-2007004916-A1
优先权日:2004-01-16
标题:Process for the production of cefotaxime sodium
发明人：JAWEED MUKARRAM SIDDIQUI M; KHAN RASHID A R; YADAV RAM P; KHAN MOHAMMED Y
权利人:WOCKHARDT LTD
摘要:A process for the production of 7-[2-(2-amino-4-thiazolyl)-2-syn-methoxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid (Cefotaxime) in aqueous isopropyl alcohol is provided. The synthesis provides the product in greater than 99 % HPLC purity.

专利号:WO-2005105813-A1
优先权日:2004-04-28
标 题 :Improved process for the manufacture of ceftriaxone sodium
发明人：JAWEED MUKARRAM SIDDIQUI MOHAM; NAITHANI PANKAJ KUMAR; PUROHIT MANISH; POKALWAR RAJKUMAR UDHAVRAO
权利人:WOCKHARDT LTD; JAWEED MUKARRAM SIDDIQUI MOHAM; NAITHANI PANKAJ KUMAR; PUROHIT MANISH; POKALWAR RAJKUMAR UDHAVRAO
摘要:A process for the production of (6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-syn­methoxyimino)acetamido]-3-[[2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3­yl)thio]methyl]-8-oxo-5-thia-l-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid (Ceftriaxone acid) in water is discussed. The synthesis is effected by condensing (7R)-7-Amino-3­deacetoxy-3-[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]cephalosporanic acid (7-ACT) with 2-(2-chloroacetamido-4-thiazolyl)-2-syn-methoxyiminoacetyl chloride followed be deblocking amino function. Finally, (6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-syn­methoxyimino)acetamido]-3-[[2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3­yl)thio]methyl]-8-oxo-5-thia-l-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid (Ceftriaxone acid) is converted into Ceftriaxone disodium hemiheptahydrate in aqueous acetone using sodium-2-ethylhexanoate as sodium source. Isolation steps at every stage are quite short. The purity of the final product is obtained in more than 99 % by HPLC profile.

专利号:CN-104926690-A
优先权日:2015-06-11
标题:A method and device for recovering and refining acetonitrile in the synthesis of ceftriaxone sodium

专利号:CN-101096364-A
优先权日:2006-06-26
标题:A new process for catalytic synthesis of AE-active ester

专利号:CN-104803503-B
优先权日:2015-01-15
标 题 :A kind of processing means of wastewater from cephalosporin synthesis pharmaceutical production