CAS: 13518-40-6; (S)-Tert-Butyl 2-Amino-3-Methylbutanoate Hydrochloride

相似化合物

13211-31-9 104944-18-5 6070-59-3

上下游产品

CAS号72-18-4 l-缬氨酸 | CAS号115-11-7 2-甲基丙烯 | CAS号75-65-0 叔丁醇 | CAS号192725-87-4 N-(3-丙酰氨基)-L-缬氨... | CAS号13211-31-9 L-缬氨酸叔丁酯盐酸盐

L-缬氨酸,异丁烯置于硫酸体系中,用 1,4-二氧六环 用作溶剂,以50%的收率获得l-缬氨酸叔丁酯盐酸盐
参考文献:氨基酸和肽的研究x:HPLC介导的2,4-双(4-甲氧基苯基)-1,3,2,4-二硫代二磷-苯丙氨酸2,4-二硫化物(劳氏试剂)的无消旋偶联试剂
标题:氨基酸和肽的研究x:HPLC介导的2,4-双(4-甲氧基苯基)-1,3,2,4-二硫代二磷-苯丙氨酸2,4-二硫化物(劳氏试剂)的无消旋偶联试剂
摘要:已经测试了易于获得的2,4-双(4-甲氧基苯基)-1,3,2,4-二硫代二膦2,4-二硫化物(lawesson'S Reagent)1作为肽合成中外消旋的偶联剂.测定步骤是通过HPLC分离立体异构产物.Zs-Pro-S-Val-S-Pro-Otbu和zs-Leu-S-Phe-S-Val-Otbu被用作2 + 1段偶联的测试肽,并且只有少量差向异构(0.5和分别观测到<0.1%).
Doi:10.1016/s0040-4020(01)91366-3

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2010022767-A1
优先权日:2008-07-25
标题 :Development of a synthesis of syringolin a and b and derivatives thereof
发明人：KAISER MARKUS; CLERC JEROME
权利人:MAX PLANCK GESELLSCHAFT
摘要:The synthesis of syringolin A and B and derivatives thereof as well as to pharmaceutical compositions containing the syringolin A or B or derivatives thereof and the use of syringolin A and B and derivatives thereof for prophylaxis and treatment of cancer.

专利号:US-8044173-B2
优先权日:2005-09-13
标 题 :Asymmetric synthesis of peptides
发明人：HARWOOD LAURENCE M; YAN RAN
权利人:UNIV READING
摘要:A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR 8 , where R 8 is C 1-6 alkyl, C 6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemisation, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.

专利号:US-8399612-B2
优先权日:2005-09-13
标 题 :Asymmetric synthesis of peptides
发明人：HARWOOD LAURENCE M; YAN RAN
权利人:HARWOOD LAURENCE M; YAN RAN; UNIV READING
摘要:A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR 8 , where R 8 is C 1-6 alkyl, C 6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemization, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerization.

专利号:US-6495693-B2
优先权日:1996-11-22
标题:N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; PORTER WARREN J; THORSETT EUGENE D; WU JING
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6248866-B1
优先权日:1997-10-31
标 题:Hypusine reagent for peptide synthesis
发明人：BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:A derivative of hypusine useful as a reagent for synthesizing peptides containing hypusine, as well as an improved method for synthesizing the same, the derivative having the formula:wherein: Q1 and Q2 may be the same or different and are amino protective groups; Q3 is an amino protective group which is orthogonal to Q1 and Q2; and Z is a hydroxy protective group.