CAS: 18449-41-7; (1S,2R,4As,6As,6Br,8R,8Ar,9R,10R,11R,12Ar,12Br,14Bs)-8,10,11-Trihydroxy-9-(Hydroxymethyl)-1,2,6A,6B,9,12A-Hexamethyl-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Icosahydropicene-4A-Carboxylic Acid

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CAS号23140-81-0 Methylbrahmat

Methylbrahmat置于sodium Hydroxide体系中,用 乙二醇 用作溶剂,化学反应生成羟基积雪草苷
参考文献:积雪草化学检验-iii
标题:积雪草化学检验-iii
摘要:通过物理和化学数据,降解研究以及与积雪草酸的直接相关性,已阐明婆罗酸的结构为2α,3β,6β,23-Tetrahydroxy-28-Oic-Urs-12-Ene (Ia).
Doi:10.1016/s0031-9422(00)85642-3

专利信息

专利号:US-5955083-A
优先权日:1996-01-03
标 题 :Use of eriobotrya japonica extract, in particular in cosmetics for stimulating glycosaminoglycan synthesis
发明人：BONTE FREDERIC; DUMAS MARC
权利人:LVMH RECH
摘要:PCT No. PCT/FR97/00009 Sec. 371 Date Aug. 28, 1997 Sec. 102(e) Date Aug. 28, 1997 PCT Filed Jan. 3, 1997 PCT Pub. No. WO97/06659 PCT Pub. Date Feb. 27, 1997The invention concerns novel uses of an Eriobotrya japonica extract, in particular in cosmetics or pharmaceutics. This extract permits stimulation of glycosaminoglycan synthesis, in particular of hyaluronic acid, thus imparting to the cosmetic compositions containing this extract the properties of improving the firmness and suppleness of the skin, combating the formation of wrinkles or lessening the depth thereof, smoothing the surface of the skin by means of a tightening effect, or moisturizing the skin. The invention further concerns the use of these extracts for stimulating the synthesis of glycosaminoglycans from a cell culture medium, in particular fibroblasts or keratinocytes.

专利号:US-2023157936-A1
优先权日:2021-11-24
标 题 :Anti-aging skin peel composition and method of application
发明人：ZAHR ALISAR; NGUYEN THU Q; KOCH JOHN; KELLY TATIANA
权利人:JAMRM LLC
摘要:A skincare composition and a method for removing layers of skin in a cosmetic procedure. The skincare composition comprises active ingredients mixed into a cosmetically acceptable carrier. The active ingredients include an effective amount of one or more keratolytic agents for inducing a desired degree of keratolysis in the skin, an effective amount of one or more free radical neutralizing agents for negating cellular damage from reactive chemical species, and an effective amount of one or more agents increasing synthesis of dermal components. The one or more free radical neutralizing agents and the one or more agents increasing synthesis of dermal components are acids in their un-neutralized, natural acid form, and a total amount of the active ingredients is less than 50 w/w% of the skincare composition, and a pH of the skincare composition is between 1.5-3.5.

专利号:US-6193975-B1
优先权日:1996-11-07
标题:Use of potentilla erecta extract in the cosmetic and pharmaceutical field
发明人：BONTE FREDERIC; DUMAS MARC; CHAUDAGNE CATHERINE; MEYBECK ALAIN
权利人:LVMH RECH
摘要:The invention relates to the use of an extract of the plant Potentilla erecta in the field of cosmetics and pharmacy, especially in dermatology. The invention more particularly relates to any application in which it is sought to reinforce the dermo-epidermal junction or to improve hair condition, by the improvement of the synthesis of collagen VII by keratinocytes and/or fibroblasts. In particular, these applications concern toning of the skin, diminishing of wrinkles or hair care. The invention also relates to a novel method of culture of cells, in particular of human fibroblasts or keratinocytes, for promoting the formation of collagen VII.

专利号:US-5747538-A
优先权日:1994-03-18
标 题 :Use of ginsenoside R0 or a plant extract containing same to promote collagen synthesis
发明人：MEYBECK ALAIN; BONTE FREDERIC; DUMAS MARC; CHAUDAGNE CATHERINE
权利人:LVMH RECH
摘要:PCT No. PCT/FR95/00326 Sec. 371 Date Sep. 18, 1996 Sec. 102(e) Date Sep. 18, 1996 PCT Filed Mar. 17, 1995 PCT Pub. No. WO95/25524 PCT Pub. Date Sep. 28, 1995The use of ginsenoside R0 or a plant extract containing same to prepare a cosmetic or pharmaceutical composition, particularly a skin care composition, for promoting collagen synthesis, particularly collagen I and/or collagen III synthesis. Said cosmetic or pharmaceutical composition is administered to a mammal, particularly a human being, in order to promote collagen synthesis. A method for promoting collagen synthesis in fibroblast growth media is also disclosed.

专利号:US-2024301461-A1
优先权日:2023-01-17
标题:Recombinant Escherichia Coli for Expressing Synthesis Pathway of Asiaticoside and Application Thereof
发明人：ZHOU JINGWEN; ZENG WEIZHU; ZHAO XINGYING; XU SHA; CHEN JIAN
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses recombinant Escherichia coli for expressing a synthesis pathway of asiaticoside and application thereof, and belongs to the field of bioengineering. Rhamnosyltransferase with an amino acid sequence shown in any one of SEQ ID NO: 25 to SEQ ID NO: 29, glucosyltransferase with an amino acid sequence shown in any one of SEQ ID NO: 10 to SEQ ID NO: 17 and UGT73AH1 reported in a document are transferred into E. coli BL21 (DE3)Δpgi to realize co-expression. Fermentation results show that all 5 rhamnosyltransferases screened in the present disclosure can achieve effects, and a unique new peak appears at 0.596 min, which is consistent with a characteristic ion flow of an asiaticoside standard product. According to the present disclosure, barriers of the prior art are broken through, a new biosynthesis method for asiaticoside is provided, and industrialization of biosynthesis of asiaticoside becomes possible.

专利号:US-2009232915-A1
优先权日:2008-03-14
标 题 :Mixtures with a collagen synthesis boosting action
发明人：SCHMAUS GERHARD; FRANKE HELGE; LANGE SABINE
权利人:SYMRISE GMBH & CO KG
摘要:The invention relates to synergistically active, ternary mixtures which boost collagen synthesis and to the uses thereof, in particular for slowing down skin ageing and for wound healing of damaged skin. The invention furthermore relates to the use of the ternary mixtures according to the invention for treating the oral cavity and pharynx, and in particular therein for preventing and slowing down periodontitis, for building up periodontal connective tissue and for preventing and treating infections in the oral cavity and for wound healing in the oral cavity.