专利号:US-6624294-B2 优先权日:1999-01-08 标 题:Regioselective synthesis of 2′-O-modified nucleosides 发明人:KAWASAKI ANDREW M; FRASER ALLISTER S; MANOHARAN MUTHIAH; COOK P DAN; PRAKASH THAZHA P 权利人:ISIS PHARMACEUTICALS INC 摘要:Methods for the regioselective alkylation at the 2'-hydroxy position over the 3'-hydroxy position of nucleosides and nucleoside analogs, forming 2'-O-ester modified compounds, are disclosed. Reduction and derivatization of the 2'-O-ester provides 2'-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.
专利号:US-8664357-B2 优先权日:2008-08-08 标题 :Solvent resistant diafiltration of peptides, PNA or oligonucleotides 发明人:LIVINGSTON ANDREW GUY; PEEVA LUDMILA GEORGIEVA; SO SHEYUNG WANG JERRY; CAMPOS VASCONCELES RENATO; LEATHERBARROW ROBIN JOHN; TATE EDWARD WILLIAM; GAFFNEY PIERS ROBERT JAMES 权利人:LIVINGSTON ANDREW GUY; PEEVA LUDMILA GEORGIEVA; SO SHEYUNG WANG JERRY; CAMPOS VASCONCELES RENATO; LEATHERBARROW ROBIN JOHN; TATE EDWARD WILLIAM; GAFFNEY PIERS ROBERT JAMES; IMP INNOVATIONS LTD 摘要:According to the present invention, there is provided a process for the preparation of a first compound selected from peptides, oligonucleotides and peptide nucleic acids. The process comprises synthesizing the first compound and then separating the first compound formed in step (i) from a second compound, which is a reaction by-product of the synthesis of the first compound and/or an excess of a reagent used for the synthesis of a first compound by a process of diafiltration. The membrane used for the diafiltration process is stable in organic solvents and provides a rejection for the first compound which is greater than the rejection for the second compound.
专利号:US-4709028-A 优先权日:1987-02-03 标 题 :Synthesis of heterocyclic amines via the reaction of dialkylene glycol and ammonia 发明人:JOHNSON THOMAS A; COOPER CAWAS A 权利人:AIR PROD & CHEM 摘要:This invention relates to an improved process for producing a heterocyclic amine, e.g., morpholine and its derivatives by reacting ammonia and a dialkylene glycol. The improvement resides in adding an inert solvent in the form of an alkyl ether of a polyalkylene glycol with said feed. By including such inert solvent one reduces heavies formation particularly at high conversion.
专利号:US-6774180-B2 优先权日:2000-12-18 标 题:Synthesis of high molecular weight non-peptidic polymer derivatives 发明人:KOZLOWSKI ANTONI; SHEN XIAOMING; BENTLEY MICHAEL DAVID; FANG ZHIHAO 权利人:NEKTAR THERAPEUTICS AL CORP 摘要:High molecular weight derivatives of activated poly(ethylene glycol) and the like polymers are prepared in high purity by conjugating a large PEG molecule to a small PEG molecule. Most of the reaction steps can be accomplished on the more readily purified small molecule to avoid laborious purification of the high molecular weight derivatives.
专利号:US-4996315-A 优先权日:1990-01-16 标 题:Novel synthesis of cyclic compounds 发明人:SPERANZA GEORGE P; LIN JIANG-JEN 权利人:TEXACO CHEMICAL 摘要:Novel cyclic ester-amides having the formula: where R is an alkyl group having from 2 to 5 carbon atoms, and x ranges from 2 to 6 by reacting a polyethylene glycol monoamine having the formula NH2-(CH2CH2O)x-H, where x is as above, with at least one dicarboxylic acid, where the dicarboxylic acid is selected from the group consisting of glutaric, adipic, pimelic acids and mixtures thereof. The a molar ratio of polyethylene glycol monoamine to dicarboxylic acid should be about 1:1. Catalysts may be optionally used, and may include such compounds as titanium alkoxides; and zinc, manganese and antimony salts of carboxylic acids. This method is anticipated to be a useful step in a new preparation of valuable cyclic products.
专利号:US-8796394-B2 优先权日:2009-08-27 标 题 :Antifouling hydrogels, coatings, and methods of synthesis and use thereof 发明人:MESSERSMITH PHILLIP B; RIVERA JOSE; GONG YONG-KUANG 权利人:MESSERSMITH PHILLIP B; RIVERA JOSE; GONG YONG-KUANG; UNIV NORTHWESTERN 摘要:The invention provides an antifouling hydrogel comprising an effective amount of antifouling polymer modified with a compound containing catechol functional groups to yield a modified antifouling polymer comprising at least one catechol functional end group; and an effective amount of at least one oxidizing reagent, wherein the at least one oxidizing reagent reacts with the modified antifouling polymer to provide a modified antifouling polymer comprising at least one oxidized catechol end group, wherein an antifouling hydrogel is provided. Methods of synthesis, methods of use and kits of the antifouling hydrogel are also provided.