CAS: 35944-64-0; 3-Iodo-4-Methylaniline

上下游产品

CAS号7745-92-8 2-碘-4-硝基甲苯 | CAS号82998-57-0 3-碘-4甲基苯甲酸 | CAS号99-94-5 对甲基苯甲酸 | CAS号122099-11-0 4-azido-2-iodot... | CAS号109-89-7 二乙胺 | CAS号7647-01-0 盐酸 | CAS号858846-53-4 2,5-diiodo-4-me... | CAS号64-19-7 冰醋酸 | CAS号876494-97-2 2-Bromo-5-iodo-... | CAS号858846-58-9 2,6-dibromo-3-i... | CAS号882670-69-1 4-甲基-3-(4,4,5,5... | CAS号1026581-42-9 6-Iodo-5-methyl... | CAS号72255-66-4 6-(3-iodo-4-met... | CAS号73655-51-3 4-amino-2-iodob... | CAS号905439-45-4 4-(5-amino-2-me... | CAS号585544-17-8 2-chloro-N-(3-i... | CAS号623907-53-9 N-(3-碘-4-甲基苯基)-... | CAS号623907-55-1 N-(3-碘-4-甲基苯基)-... | CAS号626250-54-2 3-碘-4-甲基苯酚

2-碘-4-硝基甲苯置于sodium Tetrahydroborate,Sodium Methylate体系中,用 1,4-二氧六环,甲醇 作为反应溶剂,以98%的收率获得产物3-碘-4-甲基苯胺
参考文献:使用氮掺杂碳包封镍催化剂和 Y 型填充床柱进行化学选择性硝基还原进行连续流动反应
标题:使用氮掺杂碳包封镍催化剂和 Y 型填充床柱进行化学选择性硝基还原进行连续流动反应
摘要:利用廉价的 Nabh 4在室温下 5 分钟内实现了含硝基芳烃和杂芳烃的选择性还原作为氢源和新开发的 Ni@n−c 催化剂,通过简单的碳涂层工艺获得,无需外部碳源.在一般批量条件下,使用 Ni@n−c 催化剂,可以将包括药物分子在内的多种硝基衍生物成功还原为相应的胺,收率范围为 45% 至 99%.连续流动反应系统进一步提高了硝基还原的反应活性和选择性,特别是当使用新设计的y型柱时,24小时后即可生产出克级的奥希替尼中间体,没有任何镍金属污染或硅胶色谱纯化.
DOI:10.1002/adsc.202300357

专利信息

专利号:US-5998595-A
优先权日:1996-11-05
标题:Azidohalogenobenzyl derivatives, sugar compounds and protection of hydroxy groups
发明人：KUSUMOTO SHOICHI; FUKASE KOICHI
权利人:WAKO PURE CHEM IND LTD
摘要:Azidohalogenobenzyl derivatives of the formula (I) ##STR1## wherein A is a halogen atom, B is a halogen atom or a hydrogen atom, and X is a group reactive with a hydroxy group, methods of protecting hydroxy group(s) using said derivatives, and sugar compounds wherein a hydrogen atom of at least one hydroxy group is substituted by an azidohalogenobenzyl group. According to the present invention, there are provided novel derivatives capable of introducing a group into a compound having hydroxy group(s), which group is useful as a stable hydroxy-protecting group even in solid phase synthesis for the purpose of the extension of sugar chain under continuous acidic conditions and of being removed under mild conditions; sugar compounds protected by using said derivatives; and methods of protecting hydroxy group(s) using said derivatives.

专利号:CN-107428688-B
优先权日:2015-04-06
标题:Efficient synthesis of carbazole derivatives