5-氯噻唑-2-磺酰氯置于ammonium Hydroxide体系中,化学反应生成 2-氯噻吩-5-磺酰胺 参考文献:Antitumor Compositions And Methods Of Treatment 标题:Antitumor Compositions And Methods Of Treatment 摘要:这项发明提供了某些磺胺酰胺化合物,配方和使用某些磺胺酰胺化合物治疗易感肿瘤的方法.
专利信息
专利号:US-9422244-B2 优先权日:2010-01-29 标 题 :Synthesis of substituted pyrazoline carboxamidine derivatives 发明人:VAN LOEVEZIJN ARNOLD; LANGE JOSEPHUS H M; BARF GERRIT A; DEN HARTOG ARNOLD P 权利人:VAN LOEVEZIJN ARNOLD; LANGE JOSEPHUS H M; BARF GERRIT A; DEN HARTOG ARNOLD P; ABBVIE BAHAMAS LTD 摘要:This invention relates to organic chemistry, in particular to processes for the preparation of pyrazoline carboxamidine derivatives of formula (I), known as potent 5-HT6 antagonists. The invention also relates to novel intermediates of these compounds. wherein the symbols have the meanings given in the description.
专利号:WO-2011092226-A1 优先权日:2010-01-29 标 题:Synthesis of substituted pyrazoline carboxamidine derivatives
专利号:US-2013060041-A1 优先权日:2010-01-29 标题:Synthesis of substituted pyrazoline carboxamidine derivatives
专利号:CN-102725272-A 优先权日:2010-01-29 标 题 :Synthesis of Substituted Pyrazoline Carboxyamidine Derivatives
专利号:JP-2013518080-A 优先权日:2010-01-29 标 题:Synthesis of substituted pyrazoline carboxyamidine derivatives.
专利号:JP-5792195-B2 优先权日:2010-01-29 标题:Synthesis of substituted pyrazoline carboxyamidine derivatives.
[参考文献]: Tim Sparey, Et Al. Sulfonamide Derivatives Of Bridgehead Substituted Bicyclo[4.2.1]Nonanes As Gamma-Secretase Inhibitors. Bioorg Med Chem Lett. 2008 Jan 1;18(1):375-9.