CAS: 64480-66-6; Glycoursodeoxycholic Acid

上下游产品

chenodeoxycholic acid 3α,7α-dihydroxy-5β-cholan-24-oic acid 2,5-dioxopyrrolidin-1-yl ester glycine ursodeoxycholic acid ethyl ester glycine

熊去氧胆酸置于盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,三乙胺,聚甘氨酸体系中,用 二氯甲烷,二甲基亚砜 作为反应溶剂,化学反应 8.0H,反应生成 甘氨熊去氧胆酸
参考文献:Synthesis,Anticancer Activities,Antimicrobial Activities And Bioavailability Of Berberine-Bile Acid Analogues
标题:Synthesis,Anticancer Activities,Antimicrobial Activities And Bioavailability Of Berberine-Bile Acid Analogues
摘要:合成了十五种小檗碱-胆酸类似物.与小檗碱(bbr)相比,这些类似物的抗癌活性在体外进行了评估;在这些类似物中,A4,B4 和 B5 的细胞毒性高于 Bbr.大多数类似物对金黄色葡萄球菌 Atcc 25923 和白色念珠菌 Atcc 8799 具有较高的抗菌活性,而对枯草芽孢杆菌 As 1.398 和大肠杆菌 Atcc 31343 则无敏感性.a4 和 B4 在血清稳定性实验中表现出稳定性.b4 在小鼠中显示出非常好的口服生物利用度.
DOI:10.2174/157018012800673010

专利信息

专利号:WO-2020020904-A1
优先权日:2018-07-23
标题:Therapeutic uses of glp-2 agonists
发明人：LINDSTRÖM ERIK; SKARBALIENE JOLANTA
权利人:ZEALAND PHARMA AS
摘要:The invention relates to the use of GLP-2 agonists to modulate bile acid metabolism. In particular, it is believed that GLP-2 agonists may be capable of inhibiting bile acid synthesis, and so are useful for the treatment of conditions in which inhibition of bile acid synthesis is beneficial. Such conditions include primary bile acid diarrhea, secondary bile acid diarrhea and conditions which cause or contribute to cholestasis. The invention further relates to the use of FGF19 and C4 as biomarkers to monitor bile acid synthesis and homoeostasis, e.g. in SBS patients.

专利号:US-2012232169-A1
优先权日:2011-03-07
标 题 :Highly monodisperse branched peg-lipid conjugates
发明人：WU NIAN; KELLER BRIAN CHARLES
权利人:WU NIAN; KELLER BRIAN CHARLES; BIOZONE PHARMACEUTICALS INC
摘要:(PEG)-lipid conjugates and methods of preparation are disclosed herein. Methods of preparation may involve stepwise addition of small PEG oligomers to a glycerol backbone until a desired chain size is attained. Polymers resulting from the syntheses may be highly monodisperse. The resulting polymers may comprise branched polyethyleneglycol (PEG)-lipid conjugates. The present disclosure may provide several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method may be suitable for preparing a wide range of conjugates such as PEG lipid conjugates having a glycerol-like central backbone covalently attached to two or more monodisperse PEG chains and a lipid comprising a range of diesters made from fatty acids or bile acids.

专利号:US-2011040113-A1
优先权日:2009-06-02
标 题 :Pure PEG-lipid conjugates
发明人：WU NIAN; KELLER BRIAN CHARLES
权利人:WU NIAN; KELLER BRIAN CHARLES
摘要:Syntheses of polyethyleneglycol (PEG)-lipid conjugates are disclosed. Such syntheses involve stepwise addition of small PEG oligomers to a glycerol backbone until the desired chain size is attained. Polymers resulting from the syntheses are highly monodisperse. The present invention provides several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method is suitable for preparing a wide range of conjugates. n In another aspect, the invention comprises PEG lipid conjugates having a glycerol backbone covalently attached to one or two monodisperse PEG chains and one or two lipids. These conjugates are especially useful for pharmaceutical formulations.