CAS: 65610-13-1; 3-Fluorophthalonitrile

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CAS号77326-36-4 2-氨基-6-氟苯腈 | CAS号151-50-8 氰化钾 | CAS号1240518-54-0 3-氨基-1H-吲唑-4-甲腈

2-(4,4-Dimethyl-4,5-Dihydrooxazol-2-yl)-6-Fluorobenzonitrile置于氯化亚砜,N,N-二甲基甲酰胺体系中,用 Neat (No Solvent) 作为反应溶剂,化学反应 6.0H,以82%的收率获得产物3-氟邻苯二腈
参考文献:由芳基恶唑啉制备多官能化芳香腈
标题:由芳基恶唑啉制备多官能化芳香腈
摘要:来自恶唑啉的芳基腈:我们报道了一种制备高官能化三,四和五取代芳香腈的新方法,该方法通过在甲苯中使用s Bu 2 Mg 进行两次连续的镁化,然后与多种亲电子试剂发生捕获反应,然后使用草酰氯和催化量的 Dmf(50 °C,4 小时)将恶唑基导向基团有效转化为腈官能团.
DOI:10.1002/chem.202103700

专利信息

专利号:WO-8707267-A1
优先权日:1986-05-19
标 题:Method of synthesizing tetrafluorophthalonitrile
发明人：NALEWAJEK DAVID; LOCKYER GEORGE DONALD; EIBECK RICHARD ELMER; PYSZCZEK MICHAEL FRANCIS
权利人:ALLIED CORP
摘要:A process for the preparation of compounds of the general formula C6Fx(CN)y, wherein x and y are whole integers whose sum equals 6. The process is particularly useful for the synthesis of fluorinated nitriled containing at least two cyano groups (y=2). Among the preferred compounds prepared is tetrafluorophthalonitrile, a key intermediate used as a building block in the pharmaceutical industry. In the process described, tetrafluorophthalonitrile is prepared by the reaction of a chlorinated compound of general formula C6Clx(CN)y wherein x and y are whole integers whose sum equals 6. Specifically, tetrachlorophthalonitrile is reacted with potassium fluoride in an aprotic solvent to prepare tetrafluorophthalonitrile. The fluoronitrile is produced in at least 80 % yield and a minimum purity of 98.5 %. Only one additional recrystallization is required to produce a material of > 99.5 % purity. In another embodiment, the crude tetrafluorophthalonitrile is recrystallized from a hydrocarbon alkane solvent to produce a product of > 99.5 % purity which can be used directly as an intermediate. This process represents an economical means to produce tetrafluorophthalonitrile on an industrial scale.

专利号:CN-119330339-A
优先权日:2024-10-29
标 题 :Method for preparing porous carbon based on synchronous synthesis of nitrile resin/graphene nanosheets and porous carbon material