CAS: 79722-21-7; Tert-Butyl Benzyloxycarbamate

该化合物是一种有机化合物,其特点是由碳酸衍生物的矿泉反应产生的碳酸性功能组;该化合物的特征是:一个三丁基乙基混合物,它提供了消毒障碍,并增强了其稳定性,还有一种苯氧基混合物有助于其反应性和溶解性.该产品一般在室内温度下是白色和非白色固体,在二氯甲烷和乙酸乙酸酯等有机溶剂中可溶解.由于存在苯氧化合物,因此有可能在有机合成中应用,特别是在化学反应期间对氨胺的保护方面.此外,三丁丁基N(苯氧)甲酸氨基甲酸酯可以作为各种药物和农用化学品合成的前体.在标准实验室条件下,其稳定性使其在合成有机化学中成为有用的试剂.与许多有机化合物一样,由于使用该化合物可能造成的危险,应当观察到适当的处理和安全防范措施.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2687-43-6 苄氧基胺盐酸盐 | CAS号622-33-3 邻苄基羟胺 | CAS号34619-03-9 碳酸二叔丁酯 | CAS号497-19-8 纯碱 | CAS号29601-98-7 N-苄基羟胺盐酸盐 | CAS号100-51-6 苯甲醇 | CAS号78888-18-3 叔丁氧基 N-氨基甲酸丙烯 | CAS号129245-21-2 (5-氨基戊基)(苯基甲氧基)... | CAS号128173-50-2 N-(4-氰基丁基)-N-(苯... | CAS号19207-59-1 N-phenylmethoxy... | CAS号4383-24-8 1-phenyl-N-phen...

合成工艺路线路线简述

  • 24424-99-5 + 2687-43-6 = 79722-21-7
    反应条件:1.1 Reagents: 4-Methylmorpholine Solvents: Dichloromethane; 22 H,Rt
    标题:Studies At The Ionizable Position Of Cephalosporins And Penicillins: Hydroxamates As Substitutes For The Traditional Carboxylate Group
    作者:Majewski,Mark W.; Et Al
    参考文献:Journal Of Antibiotics 日期:2017 卷标:70(3) 页码:292-296]

    24424-99-5 + 2687-43-6 = 79722-21-7
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: 1,4-Dioxane,Water; Overnight,Rt1.2 Reagents: Citric Acid Solvents: Water; Ph 4,Rt
    标题:Structural Requirements Of Histone Deacetylase Inhibitors: Saha Analogs Modified On The Hydroxamic Acid
    作者:Bieliauskas,Anton V.; Et Al
    参考文献:Archiv Der Pharmazie (Weinheim 日期:2016 卷标:349(5) 页码:373-382]

    24424-99-5 + 622-33-3 = 79722-21-7
    反应条件:1.1 Solvents: Dichloromethane
    标题:Rational Design,Development,And Stability Assessment Of A Macrocyclic Four-Hydroxamate-Bearing Bifunctional Chelating Agent For 89Zr
    作者:Seibold,Uwe; Et Al
    参考文献:Chemmedchem 日期:2017 卷标:12(18) 页码:1555-1571]

    24424-99-5 + 622-33-3 = 79722-21-7
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: 1,4-Dioxane,Water; Overnight,Rt
    标题:Acyloxybenzyl And Alkoxyalkyl Prodrugs Of A Fosmidomycin Surrogate As Antimalarial And Antitubercular Agents
    作者:Courtens,Charlotte; Et Al
    参考文献:Acs Medicinal Chemistry Letters 日期:2018 卷标:9(10) 页码:986-989]

    100-51-6 + 219547-77-0 = 79722-21-7
    反应条件:1.1 Reagents: Lithium Bis(Trimethylsilyl)Amide Solvents: Tetrahydrofuran; -78 °C1.2 -78 °C -> Rt
    标题:Lithium Hexamethyldisilazide
    作者:Gray,Matthew; Et Al
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2004 卷标:1 页码:1-12]

    100-51-6 + 219547-77-0 = 79722-21-7
    反应条件:1.1 Reagents: Lithium Bis(Trimethylsilyl)Amide Solvents: Tetrahydrofuran1.2 -1.3 Reagents: Water
    标题:Synthesis Of O-Alkylhydroxylamines By Electrophilic Amination Of Alkoxides
    作者:Foot,Oliver F.; Et Al
    参考文献:Chemical Communications (Cambridge) 日期:2000 卷标:(11) 页码:975-976]

    24424-99-5 + 2687-43-6 = 79722-21-7
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: 1,4-Dioxane,Water
    标题:Alkylation Of N-Benzyloxyureas And Carbamates
    作者:Sulsky,Richard; Et Al
    参考文献:Tetrahedron Letters 日期:1989 卷标:30(1) 页码:31-4]

    100-51-6 + 219547-77-0 = 79722-21-7 [标题:Reaction Conditions
    标题:Product Class 5: Hydroxylamines
    作者:Geffken,D.; Et Al
    参考文献:Science Of Synthesis 日期:2009 卷标:40 页码:937-1082]

    = 79722-21-7
    反应条件:1.1 Reagents: N-Hydroxyphthalimide,Potassium Carbonate Solvents: Dimethyl Sulfoxide1.2 Reagents: Hydrazine Solvents: Ethanol; Reflux2.1 Solvents: Water
    标题:Effect Of Substituents And Stability Of Transient Aluminum-Aminals In The Presence Of Nucleophiles
    作者:Barrios,Francis J.; Et Al
    参考文献:Synthesis 日期:2015 卷标:47(2) 页码:175-180]

    16653-19-3 = 79722-21-7
    反应条件:1.1 Reagents: Hydrazine2.1 -
    标题:Fluorescent Hydroxylamine Derived From The Fragmentation Of Pamam Dendrimers For Intracellular Hypochlorite Recognition
    作者:Wu,Te-Haw; Et Al
    参考文献:Chemistry - A European Journal 日期:2013 卷标:19(35) 页码:11672-11675]

    524-38-9 = 79722-21-7
    反应条件:1.1 Reagents: Potassium Carbonate2.1 Reagents: Hydrazine3.1 -
    标题:Fluorescent Hydroxylamine Derived From The Fragmentation Of Pamam Dendrimers For Intracellular Hypochlorite Recognition
    作者:Wu,Te-Haw; Et Al
    参考文献:Chemistry - A European Journal 日期:2013 卷标:19(35) 页码:11672-11675]

    524-38-9 = 79722-21-7
    反应条件:1.1 Reagents: Potassium Carbonate2.1 Reagents: Hydrazine3.1 -
    标题:Fluorescent Hydroxylamine Derived From The Fragmentation Of Pamam Dendrimers For Intracellular Hypochlorite Recognition
    作者:Wu,Te-Haw; Et Al
    参考文献:Chemistry - A European Journal 日期:2013 卷标:19(35) 页码:11672-11675
O-苄基羟胺置于二碳酸二叔丁酯体系中,用 四氢呋喃 作为反应溶剂,化学反应 24.0H,以95%的收率获得产物n-(苄氧基)氨基甲酸叔丁酯
参考文献:Identification And Characterization Of Aes-135,A Hydroxamic Acid-Based Hdac Inhibitor That Prolongs Survival In An Orthotopic Mouse Model Of Pancreatic Cancer
标题:Identification And Characterization Of Aes-135,A Hydroxamic Acid-Based Hdac Inhibitor That Prolongs Survival In An Orthotopic Mouse Model Of Pancreatic Cancer
摘要:Pancreatic Ductal Adenocarcinoma (Pdac) Is An Aggressive,Incurable Cancer With A 20% 1 Year Survival Rate. While Standard-Of-Care Therapy Can Prolong Life In A Small Fraction Of Cases,Pdac Is Inherently Resistant To Current Treatments,And Novel Therapies Are Urgently Required. Histone Deacetylase (Hdac) Inhibitors Are Effective In Killing Pancreatic Cancer Cells In In Vitro Pdac Studies,And Although There Are A Few Clinical Studies Investigating Combination Therapy Including Hdac Inhibitors,No Hdac Drug Or Combination Therapy With An Hdac Drug Has Been Approved For The Treatment Of Pdac. We Developed An Inhibitor Of Hdacs,Aes-135,That Exhibits Nanomolar Inhibitory Activity Against Hdac3,Hdac6,And Hdac11 In Biochemical Assays. In A Three-Dimensional Coculture Model,Aes-135 Kills Low-Passage Patient-Derived Tumor Spheroids Selectively Over Surrounding Cancer-Associated Fibroblasts And Has Excellent Pharmacokinetic Properties In Vivo. In An Orthotopic Murine Model Of Pancreatic Cancer,Aes-135 Prolongs Survival Significantly,Therefore Representing A Candidate For Further Preclinical Testing.
DOI:10.1021/acs.Jmedchem.8B01957

海关参考信息

专利信息


专利号:US-5367113-A
优先权日:1991-10-30
标题 :Method for synthesis of desferrioxamine B, analogs and homologs thereof
发明人：BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-acid amide is subjected to a series of high yield condensations and reductions which vide desferrioxamine B in high overall yield. Alternatively, polyether analogs of desferrioxamine B can be prepared by reacting an activated polyether with the O-protected, N-protected hydroxylamine and subjecting the resulting product to a series of similar steps.

专利号:US-4987253-A
优先权日:1988-09-19
标 题 :Method for the synthesis of desferrioxamine B and analogs thereof
发明人：BERGERON RAYMOND J
权利人:UNIV FLORIDA
摘要:Disclosed is a synthesis of desferrioxamine B and analogs and homologs thereof beginning with the generation of the O-protected N-(4-cyanobutyl)hydroxylamine which is acylated at the O-benzylhydroxylamine nitrogen with either succinic or acetic anhydride. The resulting half-acid amide or amide respectively, is subjected to a series of high yield condensations and reductions which provide desferrioxamine B in 45% overall yield. Finally, a desamino analog of desferrioxamine is prepared in order to demonstrate the synthetic utility of the scheme as applied to desferrioxamine derivatives.

专利号:US-2012053350-A1
优先权日:2009-04-30
标题 :Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
发明人：MANGION IAN; HUFFMAN MARK A; RUCK REBECCA T; LYNCH JOSEPH; CHUNG JOHN Y L; MARCUNE BENJAMIN
权利人:MANGION IAN; HUFFMAN MARK A; RUCK REBECCA T; LYNCH JOSEPH; CHUNG JOHN Y L; MARCUNE BENJAMIN
摘要:A process for the preparation of alkyl esters of N-protected oxo-azacycloalkylcarboxylic acids of Formula III: comprises contacting a ketosulfoxonium ylide of Formula II: with an iridium catalyst to obtain Compound III, wherein P G1 is an amine protective group; k is 0, 1, or 2; and R U , R 1 , R 2 , and R 3 are defined herein. An embodiment of the process further com rises contacting a compound of Formula I: with a sulfoxonium halide of formula (R U ) 3 S(O)Z, wherein Z is halide, in the presence of a strong base to obtain Compound II. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.

专利号:US-5364965-A
优先权日:1992-12-09
标题 :Analogs of desferrioxamine B and method for synthesis thereof
发明人：BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:The invention relates to novel analogs of desferrioxamine, homologs thereof and methods for their synthesis.

专利号:US-2015315143-A1
优先权日:2014-05-01
标题 :N-Heterocyclic Carbene-Catalyzed Synthesis of 2-Aryl Indoles

专利号:US-5254724-A
优先权日:1991-10-30
标 题:Method for synthesis of desferrioxamine B, analogs and homologs thereof

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主要参考文献

[参考文献]: I Kursula, Et Al. Structural Determinants For Ligand Binding And Catalysis Of Triosephosphate Isomerase. Eur J Biochem. 2001 Oct;268(19):5189-96.

合成参考文献


摘要:MacMillan, D. W. C.; Watson, A. J. B., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 371.
摘要:Liu, Y.; Melchiorre, P., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 418.
摘要:Singh, R. P.; Deng, L., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 97.
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