CAS: 1521-38-6; 2,3-Dimethoxybenzoic Acid

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5653-62-3 5653-67-8 86-51-1

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CAS号91-16-7 1,2-二甲氧基苯 | CAS号124-38-9 二氧化碳 | CAS号86-51-1 2,3-二甲氧基苯甲醛 | CAS号57901-57-2 Lithium o-Lithi... | CAS号7169-06-4 2,3-二甲氧基苯甲酰氯 | CAS号148-53-8 邻香草醛 | CAS号4463-33-6 2,3-二甲氧基甲苯 | CAS号35030-98-9 3-甲氧基水杨酸乙酯 | CAS号80-48-8 对甲苯磺酸甲酯 | CAS号106092-48-2 5-methoxy-1,3-b... | CAS号5768-39-8 1,3-亚甲二氧杂环戊烯-4-羧酸 | CAS号5653-62-3 2,3-二甲氧基苯甲腈 | CAS号5653-67-8 2,3-二甲氧基苄醇 | CAS号86-51-1 2,3-二甲氧基苯甲醛 | CAS号144344-71-8 (2,3-dimethoxyp... | CAS号4463-33-6 2,3-二甲氧基甲苯 | CAS号23158-06-7 ETHYL BENZO[D][... | CAS号2169-28-0 3-羟基-2-甲氧基苯甲酸 | CAS号98-88-4 苯甲酰氯

专利信息

专利号:WO-9101724-A1
优先权日:1989-07-27
标题 :Renal-selective prodrugs for the treatment of hypertension
发明人：REITZ DAVID B; KOEPKE JOHN P; BLAINE EDWARD H; SCHUH JOSEPH R; MANNING ROBERT E; SMITS GLENN J
权利人:SEARLE & CO
摘要:Renal-selective prodrugs are described which are preferentially converted in the kidney to compounds capable of inhibiting synthesis of catecholamine-type neurotransmitters involved in renal sympathetic nerve activity. The prodrugs described herein are derived from inhibitor compounds capable of inhibiting one or more of the enzymes involved in catecholamine synthesis, such compounds being classifiable as tyrosine hydroxylase inhibitors, or as depa-decarboxylase inhibitors, or as dopamine-β-hydroxylase inhibitors. These inhibitors compounds are linked to a chemical moiety, such as a glutamic acid derivative, by a cleavable bond which is recognized selectively by enzymes located predominantly in the kidney. The liberated inhibitor compound is then available in the kidney to inhibit one or more of the enzymes involved in catecholamine synthesis. Inhibition of renal catecholamine synthesis can suppress heightened renal nerve activity associated with sodium-retention related disorders such as hypertension. Conjugates of particular interest are glutamyl derivatives of dopamine-β-hydroxylase inhibitors, of which N-acetyl-Y-glutamyl fusaric acid is preferred.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-9422306-B2
优先权日:2012-12-21
标题:Artemisinin compounds and synthesis and use thereof
发明人：SASAKI TOMIKAZU; WANG SHUSHENG
权利人:UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
摘要:The present disclosure describes artemisinin compounds. The compounds can be synthesized using an Ugi synthesis reaction and can be used in the treatment of cancers, parasitic infections and yeast infections.

专利号:WO-2013084241-A1
优先权日:2011-12-09
标题:Compounds as inhibitors of renin
发明人：THOMBARE PRAVIN S; DESAI JIGAR N
权利人:CADILA HEALTHCARE LTD; THOMBARE PRAVIN S; DESAI JIGAR N
摘要:The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to processes for preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.