专利号:US-10053406-B2 优先权日:2015-10-23 标题 :Synthesis of honokiol 发明人:JARACZ STANISLAV; KOZLOWSKI MARISA; EUN LEE YOUNG; KIM SUN MIN 权利人:COLGATE PALMOLIVE CO; UNIV PENNSYLVANIA 摘要:Disclosed herein are improved methods for the synthesis of honokiol, as well as methods for the synthesis of 3,3′-di-tert-butyl-5,5′-dimethyl-[1,1′-biphenyl]-2,4′-diol, 3′,5-dimethyl-[1,1′-biphenyl]-2,4′-diol, and 2,4′-dimethoxy-3′,5-dimethyl-1,1′-biphenyl, 3,3′,5,5′-tetra-tert-butyl-[1,1′-biphenyl]-2,4′-diol, and certain tetrasubstituted bisphenols, and uses therefor.
专利号:US-6187925-B1 优先权日:1997-12-23 标 题 :Intermediates and process for the synthesis of azasteroids 发明人:HUMPHREY GUY R; MILLER ROSS A; LI WENJIE 权利人:MERCK & CO INC 摘要:The novel process of this invention involves the stereoselective synthesis of certain 16-substituted 4-aza-5alpha-androst-1-en-3-ones, and the useful intermediates obtained therein.
专利号:US-6143887-A 优先权日:1998-05-14 标题:Process for the stereoselective synthesis of 16-substituted-4-aza-androstanones 发明人:GRATALE DOMINICK F; TOLMAN RICHARD L; SAHOO SOUMYA P 权利人:MERCK & CO INC 摘要:The novel process of the present invention involves the stereoselective synthesis of certain 16β-substituted 4-aza-5α-androstan-3-ones and the useful intermediates obtained therein.
专利号:EP-0062322-A1 优先权日:1981-04-03 标 题 :Improved process for synthesis of hindered amine stabilizers for polymeric materials 发明人:LAI JOHN TA-YUAN 权利人:GOODRICH CO B F 摘要:Process for the synthesis of hindered polysubstituted α-amino acetamides by reaction of a secondary amine with an α-halo acetamide in a basic organic reaction medium and in the presence of a phase transfer catalyst. The product thus obtained can comprise a multifunctional compound having one or more hindered amino moieties. These compounds are highly effective as UV stabilizers in a variety of plastics, especially the alpha monoolefins.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-12098124-B2 优先权日:2019-04-16 标 题:Acid catalyzed synthesis of methyl acrylate from acrylic acid and methanol 发明人:CHAKRABARTI REETAM; NGO MINH N; ELDER JAMES 权利人:ROHM & HAAS 摘要:A method for preparing methyl acrylate comprises:a) heating in a reaction zone a mixture comprising acrylic acid, methanol, and an acid catalyst to react and form a reaction product comprising methyl acrylate which is vaporized with other light components and then fed to a distillation zone, wherein a feed stream entering the reaction zone comprises methanol to acrylic acid in a molar ratio of greater than 1 and less than 2, and a residence time in the reaction zone ranges from 0.25 to 2 hours;b) condensing and phase-separating a distillate from the distillation zone to form an organic phase comprising methyl acrylate and an aqueous phase;c) returning a portion of the organic phase to the distillation zone as organic reflux; andd) feeding the remainder of the organic phase and the aqueous phase of the distillation zone to an extraction column to form a methanol rich aqueous effluent and an organic effluent comprising methyl acrylate.
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合成参考文献
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