专利号:US-8420850-B2 优先权日:2010-05-14 标 题:Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers 发明人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE 权利人:DUOCASTELLA CODINA LLUIS; MOLINA MARIA; ARAD OFIR; BORRELL BILBAO JOSE IGNACIO; GARCIA DAVID SANCHEZ; PETTERSON SALOM SOFIA HENRIETTE; IBERHOSPITEX SA 摘要:The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.
专利号:US-7129197-B2 优先权日:2001-08-31 标题 :Synthesis of poly-alpha olefin and use thereof 发明人:SONG WEI; HEILMAN WILLIAM J 权利人:SHELL OIL CO 摘要:One or more oligomers of an olefin are prepared in the presence of a single-site catalyst. Preferably, the olefin is an α-olefin, and the oligomers are a poly-alpha-olefin (PAO). The PAO so prepared is completely or substantially free of tertiary hydrogen resulting from isomerization. Consequently, the PAO possesses improved biodegradability, improved oxidation resistance, and/or a relatively higher viscosity index. The PAO has many useful applications, such as a component of a lubricant.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:EP-0374282-B1 优先权日:1988-12-20 标 题 :A mutant strain of a methylotrophic organism and a process for the production of a protein in a methylotrophic organism 发明人:ROGGENKAMPE RAINER O DR; JANOWICZ ZBIGNIEW A DR; HOLLENBERG CORNELIS P PROF DR 权利人:RHEIN BIOTECH GES FUER BIOTECH 摘要:The present invention relates to a mutant strain of a methylotrophic organism, a process for the production of a protein in a methylotrophic organism and a method for the selection of methanol oxidase deficient mutants of methylotrophic organisms. The present invention provides a mutant strain of a methylotrophic organism wherein the original chromosome of said mutant is defective in effecting synthesis of active molecules of at least one protein encoded by a methanol inducible gene. Upon introduction of at least one, preferably more than one expression casette, wherein each of said expression casettes comprises an regulon of a methanol inducible gene or a functionally equivalent sequence, a DNA sequence coding for a protein to be expressed, and optionally a terminator, and wherein expression of said DNA sequence is under control of said regulon a strain is obtained, which shows a remarkable over-expression of the protein encoded by the gene of the expression casette. These strains are well suited for production of pure proteins, such as methanol oxidases free of catalase.
专利号:US-6787615-B2 优先权日:2002-01-25 标 题 :Synthesis of oligomeric poly(silarylene-siloxane-acetylene)'s and their conversion to high temperature plastics, elastomers, and coatings 发明人:KELLER TEDDY M; HOMRIGHAUSEN CRAIG L 权利人:US NAVY 摘要:The invention comprises a networked polymer comprising the formula: n wherein n≧1; wherein n is an average value obtained by averaging all repeating units of the networked polymer; wherein m≧1; wherein Y is a divalent group containing one or more acetylenic groups, one or more crosslinks, or both; n wherein z is the average number of crosslinks per Y group; wherein Ar 1 and Ar 2 are independently selected aromatic groups; and wherein each R is independently selected from the group consisting of alkyl, aryl, alkylaryl, haloalkyl, haloaryl, and combinations thereof. The invention also includes prepolymers and precursors needed to make the networked polymer and processes for making all of the above. The invention also includes a ceramic composition made by pyrolysis of the networked polymer.
1: Wu J, Wei Z, Cheng P, Qian C, Xu F, Yang Y, Wang A, Chen W, Sun Z, Lu Y. Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis. Theranostics. 2020 Aug 29;10(23):10665-10679. doi: 10.7150/thno.43528. 2: Pei R, Jiang Y, Lei G, Chen J, Liu M, Liu S. Rhein Derivatives, A Promising Pivot? Mini Rev Med Chem. 2021;21(5):554-575. doi: 10.2174/1389557520666201109120855. 369:114541. doi: 10.1016/j.expneurol.2023.114541. Epub 2023 Sep 14. 36(5):2081-2094. doi: 10.1002/ptr.7429. Epub 2022 Mar 1. 179(9):1978-1997. doi: 10.1111/bph.15773. Epub 2022 Jan 6. 21(12):960-968. doi: 10.2174/1389200221666200719002128.
合成参考文献
参考文献:10.1007/s10545-011-9375-8 摘要:Breuer ME, Willems PHGM, Russel FGM, Koopman WJH, Smeitink JAM. Modeling mitochondrial dysfunctions in the brain: from mice to men. J of Inher Metab Disea. 2011 Jul 14;35(2):193–210. doi: 10.1007/s10545-011-9375-8. 参考文献:10.3390/molecules16075928 摘要:Zhao LC, Liang J, Li W, Cheng KM, Xia X, Deng X, Yang GL. The use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from Rheum palmatum L. Molecules. 2011 Jul 15;16(7):5928–37. 参考文献:10.1016/j.mce.2011.06.027 摘要:Wang Y, Li LZ, Zhang YL, Sun WJ, Zhu YQ, Cui Y, Qi L. LC, a novel estrone-rhein hybrid compound, promotes proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells. Mol Cell Endocrinol. 2011 Sep 15;344(1-2):59–68. doi: 10.1016/j.mce.2011.06.027. 参考文献:10.1007/s00213-011-2405-2 摘要:Pattij T, Schetters D, Schoffelmeer AN, van Gaalen MM. On the improvement of inhibitory response control and visuospatial attention by indirect and direct adrenoceptor agonists. Psychopharmacology (Berl). 2012 Jan;219(2):327–40.