CAS: 487-70-7; 2,4,6-Trihydroxybenzaldehyde

该化合物是一种含有分子式C7H6O4的苯甲醚化合物,在苯环上有三种对称的羟基组别,加强了其在电子生殖性芳香替代和电动反应中的回活动,该化合物在有机合成中广泛用作中间体,特别是在生产药品,染料和协调综合体方面,其高纯度和稳定性使其适合精确的化学应用.多个氢氧基组的存在还允许选择性的功能化,使专门研究或工业过程能够有针对性地进行修改.建议适当处理,因为在某些条件下,它有可能对氧化产生敏感度.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

3,5-dihydroxyphenol brom°Cyane hydrogen cyanide Formanilid 2-hydroxy-4,6-dimethoxybenzaldehyde 1-benzo[1,3]dioxol-5-yl-3-(2,4,6-trihydroxy-phenyl)-propenone 5,7-diacetoxy-3-(3',4',5'-trimethoxyphenyl)-2H-1-chromen-2-one 5,7-diacetoxyl-2-chromenone

合成工艺路线路线简述

    间苯三酚 以80的收率获得产物间苯三酚甲醛
    参考文献:Imidazothiadiazole And Imidazopyrazine Derivatives As Protease Activated Receptor 4 (Par4) Inhibitors For Treating Platelet Aggregation
    标题:Imidazothiadiazole And Imidazopyrazine Derivatives As Protease Activated Receptor 4 (Par4) Inhibitors For Treating Platelet Aggregation
    摘要:本发明提供了式i的噻唑化合物,其中w,Y,R0,R2,R4,R5,R6,R7,X1,X2,X3和x4如本文所定义,或其立体异构体,互变异构体,药学上可接受的盐,前药酯或其溶剂化合物形式,其中所有变量均如本文所定义.这些化合物是血小板聚集抑制剂,因此可用作治疗或预防血栓栓塞性疾病的药物.

    海关参考信息

    专利信息


    专利号:US-8513395-B2
    优先权日:2005-06-15
    标题:Method for the synthesis of anthocyanins
    发明人:BAKSTAD EINAR
    权利人:BAKSTAD EINAR; BIOSYNTH AS
    摘要:The present invention relates to methods of preparing anthocyanins, and methods of preparing precursors of anthocyanins. The methods utilize a coupling reaction between a sugar and a suitable electrophilic precursor to form Eastern half intermediates that are then reacted with Western half intermediates to form the target anthocyanins. Some Eastern half intermediates and electrophilic precursors also form part of the invention.

    专利号:US-10017391-B2
    优先权日:2015-04-23
    标题:Direct polymer templating synthesis of mesoporous carbon
    发明人:DAI SHENG; NELSON KIMBERLY M
    权利人:UT BATTELLE LLC; UNIV TENNESSEE RES FOUND
    摘要:The invention is directed to a method for fabricating a mesoporous carbon composite material. The method comprises providing a precursor composition and subjecting the precursor material to a curing step followed by carbonization step. The precursor composition comprises (i) a templating component comprised of a linear homopolymer material, (ii) a phenolic compound or material, (iii) a crosslinkable aldehyde component, and (iv) an acid catalyst.

    专利号:US-7056348-B2
    优先权日:2001-04-19
    标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
    发明人:SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
    权利人:WELLA AG
    摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.

    专利号:US-5070212-A
    优先权日:1989-03-28
    标题:Intermediates useful for the synthesis of delphinidin chloride
    发明人:GABETTA BRUNO; GIORGI RAFFAELLO
    权利人:IDB HOLDING SPA
    摘要:A process is provided for producing delphinidin which comprises reacting a compound of formula ##STR1## wherein each Pg represents a hydroxyl protecting group, and Lg represents a leaving group with a compound of formula ##STR2## wherein Pg' represents a hydroxyl protecting group characterized in that the compound of formula VII is produced from an intermediate of formula ##STR3## wherein each Pg' represents a hydroxyl protecting group and each Alk represents lower alkyl, by n (i) subjecting the intermediate of formula IX to hydrolysis and decarboxylation to form 3,4,5-trihydroxyacetophenone of formula ##STR4## (ii) converting the 3,4,5-trihydroxyacetophenone to the compound of formula VII by introduction of the protecting groups Pg' and converting the group of formula --COCH 3 to a group of formula --COCH 2 Lg.

    专利号:EP-0348121-B1
    优先权日:1988-06-20
    标题 :Process for the synthesis of anthocyanidines and novel intermediates produced in said processes
    摘要:A novel procedure is provided for producing anthocyanidines by reacting 2,4-di-O-protected derivative phloroglucinaldehyde of formula VII wherein Pg<1> and Pg<2> each represents an O-protecting group with a compound of formula V wherein in Ar represents optionally substituted aryl and Pg<3> represents a O-protecting group. Protecting groups in the resulting condensation product are optionally converted to free hydroxyl groups. The invention further provides a novel method for producing phloroglucinaldehyde derivatives of formula VII as well as a novel procedure for producing phloroglucinaldehyde itself.

    专利号:US-2019271015-A1
    优先权日:2018-01-17
    标题 :Enzymatic synthesis of kavalactones and flavokavains
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    主要参考文献

    [参考文献]: Forester Sc, Et Al. Gut Metabolites Of Anthocyanins, Gallic Acid, 3-O-Methylgallic Acid, And 2,4,6-Trihydroxybenzaldehyde, Inhibit Cell Proliferation Of Caco-2 Cells. J Agric Food Chem. 2010 May 12;58(9):5320-7.
    [参考文献]: Kim Kn, Et Al. 2,4,6-Trihydroxybenzaldehyde, A Potential Anti-Obesity Treatment, Suppressed Adipocyte Differentiation In 3T3-L1 Cells And Fat Accumulation Induced By High-Fat Diet In C57Bl/6 Mice. Environ Toxicol Pharmacol. 2015 Mar;39(2):962-8.
    [参考文献]: Marton A, Et Al. Vanillin Analogues O-Vanillin And 2,4,6-Trihydroxybenzaldehyde Inhibit Nfĸb Activation And Suppress Growth Of A375 Human Melanoma. Anticancer Res. 2016 Nov;36(11):5743-5750.
    [参考文献]: Kil-Nam Kim, Et Al. 2,4,6-Trihydroxybenzaldehyde, A Potential Anti-Obesity Treatment, Suppressed Adipocyte Differentiation In 3T3-L1 Cells And Fat Accumulation Induced By High-Fat Diet In C57Bl/6 Mice. Environ Toxicol Pharmacol. 2015 Mar;39(2):962-8.
    [参考文献]: Vanisree Mulabagal, Et Al. Health-Beneficial Phenolic Aldehyde In Antigonon Leptopus Tea. Evid Based Complement Alternat Med. 2011:2011:601249.

    合成参考文献


    摘要:Wu, F.; Zhu, S., Science of Synthesis Knowledge Updates, (2020) 1, 167.
    摘要:Wu, F.; Zhu, S., Science of Synthesis Knowledge Updates, (2020) 1, 164.
    摘要:Biochemical Journal., 34(1196), 1940
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1007/s10886-006-9081-4
    摘要:McLean S, Duncan AJ. Pharmacological Perspectives on the Detoxification of Plant Secondary Metabolites: Implications for Ingestive Behavior of Herbivores. Journal of Chemical Ecology. 2006 May 23;32(6):1213–28. doi: 10.1007/s10886-006-9081-4.
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