CAS: 512-56-1; Trimethylphosphate

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78-40-0 598-02-7 512-56-1

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CAS号67-56-1 甲醇 | CAS号152-18-1 硫代磷酸三甲酯 | CAS号121-45-9 亚磷酸三甲酯 | CAS号124-41-4 甲醇钠 | CAS号7357-14-4 1-dimethoxyphos... | CAS号74532-26-6 1-decenyl dimet... | CAS号10113-28-7 TRIS(PHENYL,MET... | CAS号1665-79-8 2,2,2-三甲氧基-4,5-... | CAS号822-06-0 六亚甲基二异氰酸酯 | CAS号950-35-6 甲基对氧磷 | CAS号50-00-0 甲醛 | CAS号3315-60-4 methoxide anion | CAS号2697-42-9 [amino(methoxy)... | CAS号7351-83-9 dimethyl phosph... | CAS号74-89-5 氨基甲烷 | CAS号1118-00-9 1-Methoxy-2,2-d... | CAS号106580-21-6 2,6-bis(dimethy... | CAS号32586-82-6 磷酸二甲酯钠盐 | CAS号59557-93-6 1-溴-4-(二甲基氨基)萘 | CAS号50638-49-8 4-溴-2,N,N-三甲基苯胺

O,O,O-三甲基巯基磷酸酯置于臭氧体系中,化学反应 2.5H,反应生成 磷酸三甲酯
参考文献:用过氧化氢或臭氧氧化 O,O,O-三甲基硫代磷酸酯
标题:用过氧化氢或臭氧氧化 O,O,O-三甲基硫代磷酸酯
摘要:在温和的条件下,用过氧化氢或臭氧将 O,O,O-三甲基硫代磷酸酯氧化为 相应的氧代(p = O)化合物.发现过氧化氢尿素是可使用的固态过氧化氢源;它是一种比30%过氧化氢更好的氧化剂,收率更高.还证明了臭氧是最有效的氧化剂,与过氧化氢相比,反应生成纯度更高的产品,产率更高(90.1%).
DOI:10.1007/s11164-011-0404-X

专利信息

专利号:US-7301006-B2
优先权日:2002-07-16
标 题 :Methods and materials for the synthesis of modified peptides
发明人：YOUNG TRAVIS G; KIESSLING LAURA L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.

专利号:WO-2024185734-A1
优先权日:2023-03-03
标 题:Polyphosphorylated nucleoside, phosphate-activated nucleotide used for synthesis of polyphosphorylated nucleoside and method for synthesis of same, and method for synthesis of polyphosphorylated nucleoside using phosphate-activated nucleotide
发明人：KATAOKA MASANORI; FUKUI CHIHARU; TSUJI YOHEI; FUJIMURA Kazuma
权利人:NATIAS INC
摘要:The present invention provides: a polyphosphorylated nucleoside which has a structure represented by formula (I) and can be efficiently produced by a short process and a simple operation with use of a less expensive material; a phosphate-activated nucleotide which is used for the synthesis of the polyphosphorylated nucleoside and a method for the synthesis of this phosphate-activated nucleotide; and a method for the synthesis of a polyphosphorylated nucleoside using a phosphate-activated nucleotide. In the formula, B represents a protected or unprotected, natural or artificial nucleoside base; R 1 , R 2 , R 4 and R 5 each represent H or an alkyl group or the like, and R 1 , R 2 , R 4 and R 5 may be the same as or different from each other; X and Y each represents H, OH, OCH 3 or the like; h represents an integer of 1 to 3; p, n, m and q each represent 0 or an integer, and p, n, m and q are in no particular order; and (p + n + m + q) is an integer of 0 to 5,000.

专利号:US-8138330-B2
优先权日:2006-09-11
标 题 :Process for the synthesis of oligonucleotides
发明人：LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED
权利人:LEUCK MICHAEL; WOLTER ANDREAS; STUMPE ALFRED; SIGMA ALDRICH CO LLC
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides with nucleoside phosphoramidites on solid supports. The methods comprise the stepwise chain assembly of oligonucleotides on supports with 5′-acyl phosphoramidites. The synthesis cycles consist of a front end deprotection step which is conducted with a solution of a primary amine or a phenolate, a phosphoramidite coupling step with a 5′-acyl nucleoside phosphoramidite in the presence of an activator, a phosphite oxidation step and an optional capping step. The novel methods improve the quality of synthetic oligonucleotides due to the irreversibility of the front end deprotection step, which prevents the formation of deletion sequences, and due to the avoidance of acidic reagents in the synthesis cycles, which prevent the formation of depurination side products. The invention further discloses novel nucleoside phosphoramidite compositions wherein the phosphoramidites carry acyl front end protective groups which are cleavable with primary amines or phenolates. The invention is applicable to the synthesis of oligodeoxyribonucleotides, oligoribonucleotides and oligonucleotides with modifications in their sugar or phosphate groups.

专利号:US-7652164-B2
优先权日:2005-09-13
标题:Process for the direct synthesis of trialkoxysilane
发明人：LEWIS KENRICK M; MEREIGH ABELLARD T; O'YOUNG CHI-LIN; CAMERON RUDOLPH A
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:The Direct Synthesis of trialkoxysilane is carried out by conducting the Direct Synthesis reaction of silicon and alcohol, optionally in solvent, in the presence of a catalytically effective amount of Direct Synthesis catalyst and an effective catalyst-promoting amount of Direct Synthesis catalyst promoter, said promoter being an organic or inorganic compound possessing at least one phosphorus-oxygen bond.

专利号:US-9376461-B2
优先权日:2011-06-06
标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
发明人：KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B
权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC
摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.

专利号:US-5175209-A
优先权日:1987-01-06
标题:Porous wafer for segmented synthesis of biopolymers
发明人：BEATTIE KENNETH L; FROST III JAMES D
权利人:BAYLOR COLLEGE MEDICINE
摘要:A wafer for synthesizing biopolymers which includes a solid phase support material, a reaction chamber which receives and retains the support material and at least one inert porous material which allows flow through the wafer. Also included is a segmented wafer synthesis device comprising at least one, and preferably numerous, wafers for the simultaneous synthesis of multiple defined-sequenced biopolymers. Further there are process steps for synthesizing a variety of biopolymers. Synthetic polynucleotides have played a key role in studies of genetic organization through their use as primers for DNA sequencing and as hybridization probes, linkers and adapters in the cloning of genes.