专利号:US-9440928-B2 优先权日:2011-07-20 标题 :Process for the synthesis of N-substituted cyclic alkylene ureas 发明人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE 权利人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE; ALLNEX IP S AR L 摘要:The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two amino groups which may be primary or secondary, at least one of which is a primary amino group, —NH 2 , and at least one of which is a secondary amino group, >NH, the other hydrogen group whereof having been substituted by a hydrocarbyl group which in turn may be substituted by a hydroxyl group, or an amino group, or a carboxyl group, or a ketone carbonyl group, or a hydrazide or hydrazone group, or a mercaptan group, and at least one further functional group selected from the group consisting of primary or secondary amino groups and hydroxyl groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA.
专利号:US-5491245-A 优先权日:1993-03-26 标 题 :Method for the synthesis of amphoteric surfactants 发明人:GRUENING BURGHARD; WEITEMEYER CHRISTIAN 权利人:GOLDSCHMIDT AG TH 摘要:A method for the synthesis of amphoteric surfactants by the reaction of amines with chloroacetic acid or its salts in aqueous solution at an elevated temperature, consists of reacting compounds of the general formula ##STR1## with chloroacetic acid at temperatures ranging from 115° to 180° C., until the chloroacetic acid content is less than 10 ppm.
专利号:US-5367113-A 优先权日:1991-10-30 标题 :Method for synthesis of desferrioxamine B, analogs and homologs thereof 发明人:BERGERON JR RAYMOND J 权利人:UNIV FLORIDA 摘要:Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-acid amide is subjected to a series of high yield condensations and reductions which vide desferrioxamine B in high overall yield. Alternatively, polyether analogs of desferrioxamine B can be prepared by reacting an activated polyether with the O-protected, N-protected hydroxylamine and subjecting the resulting product to a series of similar steps.
专利号:US-9738647-B2 优先权日:2009-12-24 标题:Methods for the synthesis of polycyclic guanidine compounds 发明人:GRIDNEV ALEXEI 权利人:NOVOMER INC; SAUDI ARAMCO TECH CO 摘要:The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of contacting a described reagent with a triamine compound to provide a polycyclic guanidine compound.
专利号:EP-0201761-B1 优先权日:1985-04-30 标题 :Use of basic amides for increasing the porosity in paper or paper-like materials 摘要:1. Use of basic amides from amine mixtures which are obtained as tetramine bottom product in the industrial synthesis of dialkylenetriamines, in particular, dipropylenetriamine and more particularly diethylenetriamine from dihalogenoalkanes and ammonia after the triamine fraction has been distilled off or which are obtained in the industrial synthesis of diethylenetriamine and ethylenediamine from 1,2-dichloroethane and ammonia and long-chain fatty acids or fatty acid mixtures which have a melting point below 30 degrees C, for enhancing the porosity of paper or paperlike materials.
专利号:EP-1567195-B1 优先权日:2002-11-26 标题 :Dendrimer conjugates for selective solubilisation of protein aggregates 发明人:HEEGAARD PETER; BOAS ULRIK 权利人:UPFRONT CHROMATOGRAPHY AS 摘要:Dendrimer conjugates are presented, which are formed between a dendrimer and a protein solubilising substance. Such dendrimer conjugates ar effective in the treatment of protein aggregate-related diseases (e.g. prion-related diseases). The protein solubilising substance and the dendrimer together show a protein aggregate solubilising effect higher than a physical mixture of the dendrimer and the protein solubilising substance (i.e. a synergistic effect). Such dendrimer conjugates are useful in the treatment or prevention of protein aggregate-relates diseases, in disinfection/decontamination processes and in classifying or identifying protein aggregates. The synthesis of such dendrimer conjugates from readily-available starting materials is described.
1: Wotanis CK, Brennan WP 3rd, Angotti AD, Villa EA, Zayner JP, Mozina AN, Rutkovsky AC, Sobe RC, Bond WG, Karatan E. Relative contributions of norspermidine synthesis and signaling pathways to the regulation of Vibrio cholerae biofilm formation. PLoS One. 2017 Oct 18;12(10):e0186291. doi: 10.1371/journal.pone.0186291. 2: Hobley L, Kim SH, Maezato Y, Wyllie S, Fairlamb AH, Stanley-Wall NR, Michael AJ. Norspermidine is not a self-produced trigger for biofilm disassembly. Cell. 2014 Feb 13;156(4):844-54. doi: 10.1016/j.cell.2014.01.012. 3: Ou M, Ling J. Norspermidine changes the basic structure of S. mutans biofilm. Mol Med Rep. 2017 Jan;15(1):210-220. doi: 10.3892/mmr.2016.5979. Epub 2016 Dec 5.
合成参考文献
摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2019) 1, 427. 摘要:Tomás-Gamasa, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 12. 摘要:National Technical Information Service., OTS0559680 摘要:Union Carbide Data Sheet., 6/13/1968 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118