CAS: 91-60-1; 2-Naphthalenethiol

该化合物是一种有机化合物,其特征为在第二个位置上用氯化萘环替换成硫醇(-SH)组,它看起来是一种无色的黄色黄色液体,具有一种独特的气味,它看起来是无色的,是浅色的黄色液体,由于硫醇组的存在,它能够形成强大的氢结核,这也使它在各种化学反应中成为一种良好的核素.2-Naphthalenhyiol在乙醇和乙醇等有机溶剂中是可溶的,但在水中溶性有限.它经常用于有机合成,特别是在制作各种硫醇衍生物时,以及在传感器和催化剂的研制过程中作为试剂使用.此外,它表现出了诸如荧光和可参与红氧化反应等有趣的特性.然而,必须谨慎地处理这一化合物,因为它在接触时可能会对健康造成危害,包括皮肤和呼吸刺激.在实验室中与2naphlea 进行试验时,应当注意适当的安全措施.

结构式图片

相似化合物

96892-95-4 529-36-2 7433-79-6

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

bis(2-naphthyl)disulfide α-(2-phenyl-4-methylthiazol-5-yl)-α-phenylmethyl acetate naphthalene-2-sulfonic acid phenylamide 2-naphthalenylmagnesium bromide S-Naphthalen-2-yl benzenecarbothioate 2-[(naphthalen-2-yl)sulfanyl]-1-phenylethanone (naphthalen-3-yl)(2-nitrophenyl)sulfane 3-(naphthalen-2-ylsulfanyl)-propanoic acid

合成工艺路线路线简述

  • 合成目标产物 2-Naphthalenethiol 主要起始原料 2-Bromonaphthalene
  • 831-23-2 = 91-60-1
    反应条件:1.1 Catalysts: Perchloric Acid Solvents: Benzene; 1 H,80 °C
    标题:Integration Of A Four-Step Reaction Into One-Pot Under The Coexistence Of Silica-Gel-Supported Acid And Base Reagents: Synthesis Of Benzo- And Naphthothiophenes Using Nahso4/sio2 And Na2Co3/sio2
    作者:Hayakawa,Mamiko; Aoyama,Tadashi; Nakaoka,Kyohei; Kosuge,Masayuki; Ouchi,Akihiko
    参考文献:Synthesis 日期:2019 卷标:51(12) 页码:2572-2578]

    811-51-8 + 580-13-2 = 91-60-1
    反应条件:1.1 Reagents: Hydrochloric Acid
    标题:Simple Syntheses Of Aryl Alkyl Thioethers And Of Aromatic Thiols From Unactivated Aryl Halides And Efficient Methods For Selective Dealkylation Of Aryl Alkyl Ethers And Thioethers
    作者:Testaferri,L.; Tiecco,M.; Tingoli,M.; Chianelli,D.; Montanucci,M.
    参考文献:Synthesis 日期:1983 卷标:(9) 页码:751-5]

    612-55-5 = 91-60-1
    反应条件:1.1 Reagents: 1,2-Ethanedithiol,Potassium Hydroxide Catalysts: Copper Sulfate Solvents: Dimethyl Sulfoxide,Water; 20 H,90 °C
    标题:Copper(Ii)-Catalyzed Single-Step Synthesis Of Aryl Thiols From Aryl Halides And 1,2-Ethanedithiol
    作者:Liu,Yajun; Kim,Jihye; Seo,Heesun; Park,Sunghyouk; Chae,Junghyun
    参考文献:Advanced Synthesis & Catalysis 日期:2015 卷标:357(10) 页码:2205-2212]

    62141-80-4 = 91-60-1
    反应条件:1.1 Catalysts: Triphenylphosphine,Iodine Solvents: Benzene; Reflux
    标题:Triphenylphosphine-Iodine
    作者:Dormoy,Jean-Robert; Castro,Bertrand
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001]

    93-11-8 = 91-60-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran
    标题:Radical Ions. 89. One-Electron Oxidation Of Diaryl Disulfides With Aluminum Trichloride/dichloromethane
    作者:Bock,Hans; Rittmeyer,Peter
    参考文献:Phosphorus 日期:1992 卷标:68(1-4) 页码:261-91]

    93-11-8 = 91-60-1
    反应条件:1.1 Reagents: Hydrogen Catalysts: Cobalt Sulfide Solvents: Chlorobenzene
    标题:Catalytic Reduction Of 2-Naphthalenesulfonyl Chloride To 2-Thionaphthol By Hydrogen
    作者:Tret'Yakov,V. P.; Zimtseva,G. P.; Chudaev,V. V.; Rudakov,E. S.; Ponomarev,V. N.; Et Al
    参考文献:Zhurnal Prikladnoi Khimii (Sankt-Peterburg 日期:1988 卷标:61(4) 页码:948-51]

    5188-07-8 + 580-13-2 = 91-60-1 [标题:Reaction Conditions
    标题:A Convenient Synthesis Of Aromatic Thiols From Unactivated Aryl Halides
    作者:Testaferri,L.; Tingoli,M.; Tiecco,M.
    参考文献:Tetrahedron Letters 日期:1980 卷标:21(32) 页码:3099-100]

    580-13-2 = 91-60-1
    反应条件:1.1 Reagents: Cesium Carbonate,Sodium Thiosulfate Catalysts: Tris(Dibenzylideneacetone)Dipalladium,X-Phos Solvents: Tert-Butanol,Toluene,Water; Rt; 24 H,80 °C1.2 Reagents: Zinc,Hydrochloric Acid Solvents: Water; 1 H,Cooled
    标题:Palladium Catalyzed Synthesis Of Aryl Thiols: Sodium Thiosulfate As A Cheap And Nontoxic Mercapto Surrogate
    作者:Yi,Jun; Fu,Yao; Xiao,Bin; Cui,Wei-Chen; Guo,Qing-Xiang
    参考文献:Tetrahedron Letters 日期:2011 卷标:52(2) 页码:205-208]

    93-11-8 = 91-60-1
    反应条件:1.1 Reagents: Triphenylphosphine Solvents: Heptane; 85 °C; 1 H,85 °C; 85 °C -> 50 °C1.2 Reagents: Water; 10 Min,50 °C
    标题:Preparation And Characterization Of Thiophenol Compounds
    作者:Feng,Baicheng; Liu,Peng; Jing,Liqian
    参考文献:Qingdao Keji Daxue Xuebao 日期:2011 卷标:32(3) 页码:252-255]

    5586-15-2 = 91-60-1
    反应条件:1.1 Reagents: Hydrogen Catalysts: Cobalt Solvents: Tetrahydrofuran
    标题:Reduction Of Sulfonyl Chlorides To Thiols
    作者:Mylroie,Victor L.; Doles,Joseph K.
    参考文献:Chemical Industries (Dekker) 日期:1990 卷标:40 页码:189-96]

    201036-12-6 = 91-60-1
    反应条件:1.1 Solvents: Acetonitrile
    标题:Photochemistry And Photophysics Of Aromatic Sulfoxides. 9. Photochemistry Of Benzyl β-Naphthyl Sulfoxide And Characterization Of The β-Naphthylsulfinyl Radical
    作者:Guo,Yushen; Darmanyan,Alexandre P.; Jenks,William S.
    参考文献:Tetrahedron Letters 日期:1997 卷标:38(50) 页码:8619-8622]

    580-13-2 = 91-60-1
    反应条件:1.1 Reagents: Ethanethiol,Sodium Hydride Solvents: Dimethylformamide; 0 °C; 30 Min,Rt1.2 Solvents: Dimethylformamide; 24 H,Reflux; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Water
    标题:Camphor-Based Schiff Base Of 3-Endo-Aminoborneol (Sbab): Novel Ligand For Vanadium-Catalyzed Asymmetric Sulfoxidation And Subsequent Kinetic Resolution
    作者:Chuo,Ting Hung; Boobalan,Ramalingam; Chen,Chinpiao
    参考文献:Chemistryselect 日期:2016 卷标:1(10) 页码:2174-2180]

    607-53-4 = 91-60-1
    反应条件:1.1 Catalysts: 1-Naphthalenethiol
    标题:Aqueous High-Temperature Chemistry Of Carbo- And Heterocycles. Part 16. Model Sulfur Compounds: A Study Of Hydrogen Sulfide Generation
    作者:Katritzky,Alan R.; Murugan,Ramiah; Balasubramanian,Marudai; Greenhill,John V.; Siskin,Michael; Et Al
    参考文献:Energy & Fuels 日期:1991 卷标:5(6) 页码:823-34
N-Phenylnaphthalene-2-Sulfonamide置于cobalt Sulfide体系中,225.0 °C,20.59 Mpa 条件下,反应生成 2-萘硫醇
参考文献:Us2221804
标题:Us2221804

海关参考信息

专利信息


专利号:WO-0142264-A1
优先权日:1999-12-10
标 题 :Method for the synthesis of sialylated oligosaccharide donors
发明人:MEHTA SEEMA; GILBERT MICHEL; WAKARCHUK WARREN W; WHITFIELD DENNIS M
权利人:CA NAT RESEARCH COUNCIL; MEHTA SEEMA; GILBERT MICHEL; WAKARCHUK WARREN W; WHITFIELD DENNIS M
摘要:A method for the synthesis of aryl thioglycosides comprising a sialylated residue of β-D-galactose is disclosed. The method consists of preparing by a chemical synthesis a non-sialylated aryl thioglycoside, and enzymatically sialylating the latter with a sialic acid in the presence of a suitable sialyltransferase. The sialylated aryl thioglycoside is then chemically derivatized by standard procedures, to provide a derivative suitable for use as a donor in chemical syntheses of sialylated oligosaccharides. The derivatized sialylated aryl thioglycosides are prepared in high yields, due to reduced number of chemical and purification steps involved in the process. Derivatized aryl thioglycosides useful as building blocks for the synthesis of biologically active sialylated oligosaccharides are also disclosed.

专利号:US-6184168-B1
优先权日:1997-09-22
标题:Synthesis of 1,4-trans-polybutadiene using a lanthanide organic acid salt catalyst
发明人:LYNCH THOMAS J
权利人:BRIDGESTONE CORP
摘要:The invention provides a catalyst composition, comprising: (a) an organolithium compound; and, (b) an organic acid salt of lanthanide series element; wherein: (1) only components (a) and (b) are required to promote the synthesis of 1,4-trans-polybutadiene; (2) the ratio of component (a) to component (b) is selected to maximize formation of the trans structure of said 1,4-trans-polybutadiene; and, (3) components (a) and (b) are selected for enabling further diblock synthesis. The invention further contemplates a process for using the catalyst to synthesize 1,4-trans-polybutadiene and other polymers and copolymers having trans configuration in the conjugated diene monomer contributed units.

专利号:US-10150160-B2
优先权日:2014-12-04
标题 :Universal one-pot and up-scalable synthesis of SERS encoded nanoparticles
发明人:PAZOS PÉREZ NICOLÃ?S; MIR DE SIMÓN BERNAT
权利人:MEDCOM ADVANCE S A; MEDCOM ADVANCE S A
摘要:The universal one-pot and up-scalable synthesis of SERS encoded nanoparticles relies on the controlled co-absorption of mercaptoundecanoic acid (MUA) and the Raman code on the metallic surfaces of the nanoparticles. In contrast to most of the reported procedures which typically involve complex steps, the present method has demonstrated to be an easy and fast one-pot approach for the production of SERS-encoded nanoparticles. This versatile strategy allows for the SERS codification of particles with every molecule with affinity toward the metal surface, independently of its chemical nature, as exemplified here in the fabrication of 31 different encoded particles using the same standard procedure. In addition to the easiness of preparation, scalability to the liter regime, stability in aqueous solutions including PBS and chemical diversity, our SERS-encoded particles show considerably higher optical efficiency than those fabricated by using PEG or PVP polymers.

专利号:US-9409945-B2
优先权日:1999-10-04
标 题 :Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
发明人:DESLONGCHAMPS PIERRE; DORY YVES; BERTHIAUME GILLES; OUELLET LUC; LAN RUOXI
权利人:OCERA THERAPEUTICS INC
摘要:A library of macrocyclic compounds of the formula (I) n n n n n n n n n n n n where part (A) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) y — bivalent radical or a covalent bond; n where part (B) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) z — bivalent radical, or a covalent bond; n where part (C) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) t — bivalent radical, or a covalent bond; and n where part (T) is a —Y-L-Z— radical wherein Y is CH 2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

专利号:US-9908846-B2
优先权日:2014-02-21
标题:Composition, synthesis, and use of new arylsulfonyl isonitriles
发明人:FLEMING FRASER FERGUSSON; LUJAN MONTELONGO JESUS ARMANDO
权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV HOLY GHOST DUQUESNE
摘要:This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.

专利号:US-9815809-B2
优先权日:2013-07-05
标题:Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of phenols or thiophenols
发明人:LETINOIS ULLA; NETSCHER THOMAS
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane ring. It has been found that this synthesis is particularly possible in the presence of a chiral compound of formula of a specific type and of at least one phenol or thiophenol.
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参考标题:Copper-Mediated Direct Sulfenylation Of 4-Hydroxyquinolinones And 4-Hydroxypyridones With Aryl Thiols Via A C−h Functionalization Process
作者:Tao Guo,Hongyan Wang |发布日期:2017.9
摘要:An Efficient Approach For The Direct Sulfanylation Of 4-Hydroxyquinolinones And 4-Hydroxypyridones With Aryl Thiols In The Presence Of Cui/dmso Has Been Developed. The Substrate Scope Is Broad, Allowing Facile Synthesis Of A Range Of Structurally Diverse 3-Sulfanyl-4-Hydroxyquinolinones And 3-Sulfanyl-4-Hydroxypyridones In Good Efficiency.

合成参考文献


摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 75.
摘要:Sainsbury, M., Science of Synthesis Knowledge Updates, (2010) 1, 213.
摘要:Yoshimoto, F. K.; Li, Q., Science of Synthesis Knowledge Updates, (2012) 1, 248.
摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2018) 4, 178.
摘要:Beier, P., Science of Synthesis Knowledge Updates, (2014) 2, 315.
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