专利号:US-2009162290-A1 优先权日:2005-09-09 标 题 :Method for the synthesis of penta-pendant enantiomer-pure chelators and process for therapeutically active bioconjugates preparation by a covalent binding thereof 发明人:BENES IVAN; CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN 权利人:THERAPHARM GMBH 摘要:The present invention provides a method for synthesis and binding methods of pentapendant enantiomer-pure chelators of formula (VII) wherein R 1 , R 2 , R 3 , R 4 are groups forming an adequate enantiomer of the chelator; and X 1 -X 5 , Y 1 -Y 5 , Z 1 -Z 5 each individually forming pendant chelating groups.
专利号:US-7038037-B2 优先权日:2002-06-20 标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds 发明人:MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH 权利人:ISIS PHARMACEUTICALS INC 摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.
专利号:WO-2022035405-A1 优先权日:2020-08-14 标题:A drug and synthesis of the drug to treat high blood pressure and type 2 diabetes mellitus disease 发明人:AL-GBURI FIRAS SHAWQI ABDULRAZZAQ; TAYSI SEYITHAN; AL-TEKREETI NADIA YOUSIF SALEH 权利人:GAZIANTEP UNIV REKTORLUGU 摘要:The invention relates to a drug and its method of manufacture, which allows to reduce hypertension and treat type 2 diabetes mellitus by using the drug as a dipeptidyl peptidase-4 (DPP-4) inhibitor. The rate of hypoglycemia of the drug in question is low and provides glycemic control and weight loss. The method of manufacturing the mentioned drug includes practical steps to convert the carboxyl group from captopril (1) to the nitrile group.
专利号:WO-2024252006-A1 优先权日:2023-06-07 标 题:Synthesis of cyclic acyl sulfoximines 发明人:SMITS HELMARS; DUMEUNIER RAPHAEL 权利人:SYNGENTA CROP PROTECTION AG 摘要:A process for the preparation of compound of formula I is provided: (I) where R 1 , R 2 , R 3 , G 1 , and G 2 are as defined in the description.
专利号:US-2004006203-A1 优先权日:2002-06-20 标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
专利号:EP-3717521-A1 优先权日:2017-11-27 标 题:Process for the synthesis of a cyclodextrin derivative
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