CAS: 1656-44-6; 2,4-Dinitrobenzenesulfonyl Chloride

该化合物是一种化学化合物,其特点是其全氟化碳功能组和两个硝基组,放置在苯环上,该化合物通常是黄色晶状固体,在二氯甲烷和丙酮等有机溶剂中溶解,但一般在水中无法溶解,以其反应性为名,特别是在核生殖替代反应中,它可以作为灭菌剂.硝基化合物的存在,增强了其电子药理特性,使其在各种合成应用中有用,包括制备磺酰胺和其他衍生物.由于它具有反应性,必须小心处理,因为它具有腐蚀性,在接触时可能构成健康危害.适当的安全措施,包括使用个人防护设备,在实验室环境中与该化合物合作时至关重要.

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合成工艺路线路线简述

  • 合成目标产物 2,4-Dinitrobenzenesulfonyl Chloride 主要起始原料 Bis(2,4-Dinitrophenyl) Disulfide
  • (文献来源)合成步骤主要原料 Bis(2,4-Dinitrophenyl) Disulfide
双(2,4-二硝基苯)二硫化碳置于硫酸,氯体系中,化学反应生成2,4-二硝基苯磺酰氯
参考文献:307. 4-氯-2-硝基二苯基砜中基团的迁移
标题:307. 4-氯-2-硝基二苯基砜中基团的迁移
摘要:
Doi:10.1039/jr9380001618

专利信息


专利号:US-2009162290-A1
优先权日:2005-09-09
标 题 :Method for the synthesis of penta-pendant enantiomer-pure chelators and process for therapeutically active bioconjugates preparation by a covalent binding thereof
发明人:BENES IVAN; CIHELNIK SIMON; DROZ LADISLAV; SRAMEK MARTIN
权利人:THERAPHARM GMBH
摘要:The present invention provides a method for synthesis and binding methods of pentapendant enantiomer-pure chelators of formula (VII) wherein R 1 , R 2 , R 3 , R 4 are groups forming an adequate enantiomer of the chelator; and X 1 -X 5 , Y 1 -Y 5 , Z 1 -Z 5 each individually forming pendant chelating groups.

专利号:US-7038037-B2
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
发明人:MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

专利号:WO-2022035405-A1
优先权日:2020-08-14
标题:A drug and synthesis of the drug to treat high blood pressure and type 2 diabetes mellitus disease
发明人:AL-GBURI FIRAS SHAWQI ABDULRAZZAQ; TAYSI SEYITHAN; AL-TEKREETI NADIA YOUSIF SALEH
权利人:GAZIANTEP UNIV REKTORLUGU
摘要:The invention relates to a drug and its method of manufacture, which allows to reduce hypertension and treat type 2 diabetes mellitus by using the drug as a dipeptidyl peptidase-4 (DPP-4) inhibitor. The rate of hypoglycemia of the drug in question is low and provides glycemic control and weight loss. The method of manufacturing the mentioned drug includes practical steps to convert the carboxyl group from captopril (1) to the nitrile group.

专利号:WO-2024252006-A1
优先权日:2023-06-07
标 题:Synthesis of cyclic acyl sulfoximines
发明人:SMITS HELMARS; DUMEUNIER RAPHAEL
权利人:SYNGENTA CROP PROTECTION AG
摘要:A process for the preparation of compound of formula I is provided: (I) where R 1 , R 2 , R 3 , G 1 , and G 2 are as defined in the description.

专利号:US-2004006203-A1
优先权日:2002-06-20
标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds

专利号:EP-3717521-A1
优先权日:2017-11-27
标 题:Process for the synthesis of a cyclodextrin derivative
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合成参考文献


参考文献:10.1055/s-2007-992406
摘要:A Highly Selective Fluorescent Probe for Thiophenols. Synfacts. 2007 Dec 18;2008(01):0035. doi: 10.1055/s-2007-992406.
参考文献:10.1007/978-3-030-94375-2_1
摘要:Roy A, Maity CK. Defective Carbon Nanostructures for Biomedical Application. 2022. In: Advances in Material Research and Technology.
参考文献:10.1007/s40843-025-3393-8
摘要:Zhong T, Zhu T, Li Y, Wang S, Jiang Q, Zhang Y, Li Y, Cao Y. Dual-locked SO2/nanozyme delivery nanoplatform for programmed synergistic gas/chemodynamic anticancer therapy. Sci. China Mater. 2025 Jun 30;68(8):2899–909. doi: 10.1007/s40843-025-3393-8.
参考文献:10.1007/s11030-021-10194-7
摘要:Sikandar S, Zahoor AF, Naheed S, Parveen B, Ali KG, Akhtar R. Fukuyama reduction, Fukuyama coupling and Fukuyama-Mitsunobu alkylation: recent developments and synthetic applications. Mol Divers. 2022 Feb;26(1):589–628. doi: 10.1007/s11030-021-10194-7.
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