5-氯-2-硝基苯甲酸置于盐酸,Tin体系中,化学反应生成2-溴-5-氯苯甲酸 参考文献:Cohen; Raper,Journal Of The Chemical Society,1904,Vol. 85,P. 1269 标题:Cohen; Raper,Journal Of The Chemical Society,1904,Vol. 85,P. 1269
专利号:US-7196197-B2 优先权日:2003-09-17 标题:Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof 发明人:WANG ZHI-XIAN; LI YUANQIANG; GUNTOORI BHASKAR REDDY 权利人:APOTEX PHARMACHEM INC 摘要:Process for the preparation of Flecainide, its pharmaceutically acceptable salts and important intermediates thereof that involves the use of the 2-halobenzoic acid and its derivatives as a starting material. The use of this process also allows for the synthesis of a novel intermediate useful in the production of Flecainide. This new process is an inexpensive and efficient process for the manufacture of these compounds.
专利号:US-8106031-B2 优先权日:2006-05-02 标题:Hydrolytically-resistant boron-containing therapeutics and methods of use 发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A 权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC 摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.
专利号:WO-2024126692-A1 优先权日:2022-12-15 标题 :Peracid promoters in the iridium-catalyzed hydrosilylation synthesis of haloalkylorganosilanes 发明人:SCHOLZ HENRIK; KROKE EDWIN; KRAUSHAAR KONSTANTIN; GLATZER HOLGER JÜRGEN; LEWIS KENRICK MARTIN; WAGNER ROLAND 权利人:MOMENTIVE PERFORMANCE MAT GMBH 摘要:The present invention is directed at a process for producing a compound of Formula (I): (R1)y(R2O)3-ySiCH2CHR3CR4R5X comprising reacting (a) an olefinic halide; (b) an alkoxysilane; (c) a catalytically effective amount of iridium-containing catalyst; and (d) a reaction-promoting effective amount of a peroxycarboxylic acid to produce the product of Formula (I).
专利号:EP-4634196-A1 优先权日:2022-12-15 标题 :Peracid promoters in the iridium-catalyzed hydrosilylation synthesis of haloalkylorganosilanes
专利号:CN-116813475-A 优先权日:2022-06-29 标题 :A kind of halogenation synthesis method of aromatic ring compounds