4-氯苄硫醇 以 甲醇 用作溶剂,化学反应 26.0H,反应生成杀草丹 参考文献:Facile One-Pot Synthesis Of S-Alkyl Thiocarbamates 标题:Facile One-Pot Synthesis Of S-Alkyl Thiocarbamates 摘要:We Report A Novel One-Pot Two-Step Synthesis Of A Variety Of S-Alkyl Thiocarbamates. This Method Offers A Two-Directional Approach Making Use Of Trichloroacetyl Chloride,Requires No Complex Starting Material,Incorporates A Variety Of Substituents,And Proceeds In High Yields. Doi:10.1021/jo026813I
专利号:US-8021645-B2 优先权日:2006-12-13 标 题 :Synthesis of human secretory IgA and IgM and the formation of a medicament therefrom 发明人:SIMON MICHAEL R; CHERVIN STEPHANIE M; BROWN STEPHEN C 权利人:SIMON MICHAEL R; CHERVIN STEPHANIE M; BROWN STEPHEN C 摘要:A composition for treating a subject is provided. The composition includes antigen specific dimeric secretory IgA and pentameric IgM therapeutic. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of antigen specific dimeric secretory IgA and pentameric IgM with secretory component to form a antigen specific dimeric secretory IgA and pentameric secretory IgM therapeutic. The antigen specific dimeric secretory IgA and the pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, liquid or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
专利号:WO-2024256370-A1 优先权日:2023-06-13 标 题 :Synthesis of glufosinate using an amidase-based process 发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.
专利号:US-7794721-B2 优先权日:2006-12-13 标题 :Synthesis of human secretory IgM and the treatment of clostridium difficile associated diseases herewith 发明人:SIMON MICHAEL R 权利人:SIMON MICHAEL R 摘要:A composition for treating a subject is provided. The composition includes a pentameric secretory IgM therapeutic. Formulating agents are mixed with the pentameric secretory IgM to yield a dosing form of a capsule, tablet, and a suppository. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of pentameric IgM with secretory component to form a pentameric secretory IgM therapeutic. The pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
专利号:US-2025120400-A1 优先权日:2021-12-10 标题:Synthesis of glufosinate using a hydantoinase-based process 发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN 权利人:BASF SE 摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.
专利号:US-11919928-B2 优先权日:2016-03-16 标题 :Method for producing dihydrotentoxin 发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI 权利人:KUMIAI CHEMICAL INDUSTRY CO 摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.
专利号:US-2021386068-A1 优先权日:2018-11-07 标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides 发明人:KISTER JEREMY; SATCHIVI NORBERT M 权利人:CORTEVA AGRISCIENCE LLC 摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.
1: Shimasaki Y, Tsuyama M, Tasmin R, Qiu X, Shimizu M, Sato Y, Yamasaki Y, Kato-Unoki Y, Nukata A, Nakashima T, Ichinose H, Wariishi H, Honjo T, Oshima Y. Thiobencarb herbicide reduces growth, photosynthetic activity, and amount of Rieske iron-sulfur protein in the diatom Thalassiosira pseudonana. J Biochem Mol Toxicol. 2013 Sep;27(9):437-44. doi: 10.1002/jbt.21505. Epub 2013 Jun 25. doi: 10.1007/s10661-014-3893-4. Epub 2014 Jul 5. doi: 10.1016/j.chemosphere.2013.01.077. Epub 2013 Feb 22. doi: 10.1007/s10661-015-4698-9. Epub 2015 Jun 26. doi: 10.1007/s10661-011-2424-9. Epub 2011 Nov 18. doi: 10.1016/j.ecoenv.2013.03.023. Epub 2013 Apr 15. doi: 10.3109/01480545.2011.589847. Epub 2011 Sep 22. doi: 10.1016/j.ecoenv.2010.05.008. Epub 2005 Jan 26. doi: 10.1016/j.chemosphere.2015.03.032. Epub 2015 Apr 27. doi: 10.1007/s00128-015-1571-z. Epub 2015 Jun 6. doi: 10.1080/03601230802174631. doi: 10.1007/s00128-009-9810-9. doi: 10.1016/j.chemosphere.2015.04.039. Epub 2015 May 15.
合成参考文献
摘要:Japan Pesticide Information., (40)(32), 1982 摘要:Guide to the Chemicals Used in Crop Protection., 6(37), 1973 摘要:USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Thiobencarb p.8, EPA738-R-97-013 (December 1997). Available from, as of October 10, 2012: 摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present 摘要:USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Thiobencarb p.11, EPA738-R-97-013 (December 1997). Available from, as of October 10, 2012: https://www.epa.gov/pesticides/reregistration/status.htm