Lignin置于laccase 氧气体系中,化学反应生成 1,2,4-苯三酚 参考文献: Lignin Oxidation And Products Thereof[fr] Oxydation De La Lignine Et Produits Dérivés 标题: Lignin Oxidation And Products Thereof[fr] Oxydation De La Lignine Et Produits Dérivés
专利号:US-5521310-A 优先权日:1992-10-07 标 题 :Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives 发明人:CARRETERO GONZALVEZ JUAN-CARLO; VICIOSO SANCHEZ MERCEDES; GARCIA RUANO JOSE-LUIS 权利人:ETILO DERIVADOS 摘要:A process to obtain benzoxazines useful for the synthesis of Ofloxazine, Levofloxazine and derivatives. The benzoxacines (I) where Xb is an halogen and R 1 is H, alkyl or alkenyl of up to 6 atoms of C or aryl, can be obtained by means of cycling a compound of formula (II) through the reaction with triphenylphosphine and ethyl azodicarboxilate. The compounds of formula (II) can be obtained through the reaction of a compound (III) with an adequate epoxide. Through the use of the adequate chiral epoxide it is possible to obtain the enantiomerically desired intermediate and, therefore and selectively, it is possible to obtain the desired final product with the adequate enantiomeric form without the need to carry out a resolution stage. n The Compounds (I) are useful and key intermediates for the synthesis of the antimicrobials Oflixazine and Levofloxazine. ##STR1##
专利号:US-2023183177-A1 优先权日:2020-04-24 标题:Enantioselective chemo-enzymatic synthesis of optically active amino amide compounds 发明人:GRILL BIRGIT; WINKLER MARGIT; SCHWAB HELMUT; STROHMEIER GERNOT; DONSBACH KAI; WALDVOGEL SIEGFRIED R; ARNDT SEBASTIAN; WEIS DOMINIK 权利人:PHARMAZELL GMBH 摘要:The present invention relates to a novel biocatalytic process for the stereoselective preparation of alpha amino amide compounds catalyzed by NHase enzymes. A further aspect of the invention relates to novel NHase enzymes as well as further improved NHase enzyme mutants, nucleic acid molecules encoding these enzymes, recombinant microorganisms suitable for preparing such enzymes and mutants. Another aspect of the invention relates to a chemo-biocatalytic process for the preparation of lactam compounds comprising the new catalytic process for the preparation of alpha amino amide compounds catalyzed by NHase enzymes, as well as the chemical oxidation of the alpha amino amide by applying certain chemical oxidation catalysts suitable for converting the alpha amino amide under retention of its stereochemical configuration to the respective lactam. The novel chemo-biocatalytic process is particularly suited for the synthesis of valuable pharmaceutical compounds, like in particular (S)-Levetiracetam.
专利号:US-12264143-B2 优先权日:2020-12-17 标 题:Synthesis of cannabinoids and cannabinoid precursors, and related compounds, formulations, and methods of use 发明人:SAMMIS GLENN M; ROGGEN MARKUS 权利人:NALU BIO INC 摘要:Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((−)-trans-Δ9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.
专利号:US-6472190-B1 优先权日:2000-03-16 标 题:Biocatalytic synthesis of galloid organics 发明人:FROST JOHN W 权利人:UNIV MICHIGAN STATE 摘要:The present invention provides a bioengineered synthesis scheme for the production of gallic acid from a carbon source. Methods of producing gallic acid from a carbon source based on the synthesis scheme are also provided. The gallic acid produces from these methods can be further converted to pyrogallol. Methods for the biosynthesis of pyrogallol from gallic acid are also provided.
专利号:US-9169502-B2 优先权日:2010-06-15 标题 :Method of producing L-lysine using a Corynebacterium glutamicum microorganism 发明人:WITTMANN CHRISTOPH; BECKER JUDITH 权利人:WITTMANN CHRISTOPH; BECKER JUDITH; PAIK KWANG IND CO LTD 摘要:The present invention is directed to a method utilizing a recombinant microorganism for the production of aspartate derived amino acids and precursors thereof, in particular for the production of L-lysine. Furthermore, the present invention relates to a recombinant microorganism having improved aspartate-derived amino acid synthesis activity in comparison to the initial microorganism and the use of such microorganisms in producing said amino acids and precursors and derivatives, in particular in the synthesis of L-lysine.
专利号:US-2003157592-A1 优先权日:1999-12-16 标题:Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols and carotenoids 发明人:LERCHL JENS; RENZ ANDREAS; EHRHARDT THOMAS; REINDL ANDREAS; CIRPUS PETRA; BISCHOFF FRIEDRICH; FRANK MARKUS; FREUND ANNETTE; DUWENIG ELKE; SCHMIDT RALF-MICHAEL; RESKI RALF; BADUR RALF 摘要:Isolated nucleic acid molecules, designated TCMRP nucleic acid molecules, which encode novel TCMRPs from e.g. Phycomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TCMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated TCMRPs, mutated TCMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of TCMRP genes in these organisms.
参考标题:Deoxygenation Of Polyhydroxybenzenes: An Alternative Strategy For The Benzene-Free Synthesis Of Aromatic Chemicals 作者:Chad A. Hansen,J. W. Frost |发布日期:2002.5.1 摘要:E Requires 2 Enzyme-Catalyzed And 2 Chemical Steps. By Contrast, Synthesis Of Hydroquinone Using The Shikimate Pathway And Intermediacy Of Quinic Acid Requires 18 Enzyme-Catalyzed Steps And 1 Chemical Step. Methylation Of Triacetic Acid Lactone, Cyclization, And Regioselective Deoxygenation Of Phloroglucinol Methyl Ether Affords Resorcinol. Given The Ability To Synthesize Triacetic Acid Lactone From
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参考文献:10.1007/s00253-011-3451-8 摘要:Kolvenbach BA, Dobrowinski H, Fousek J, Vlcek C, Schäffer A, Gabriel FLP, Kohler HE, Corvini PFX. An unexpected gene cluster for downstream degradation of alkylphenols in Sphingomonas sp. strain TTNP3. Applied Microbiology and Biotechnology. 2011 Jul 14;93(3):1315–24. doi: 10.1007/s00253-011-3451-8.