专利号:US-6777554-B2 优先权日:2001-02-05 标题 :Preparation of N-methylparoxetine and related intermediate compounds 发明人:FINKELSTEIN NINA 权利人:TEVA PHARMA 摘要:The present invention provides a process for preparing N-methylparoxetine, an intermediate in the synthesis of paroxetine, by reacting sesamol-tetrabutylammonium salt with CIPMA. The present invention is not limited to the synthesis of N-methylparoxetine, but also includes other similar compounds.
专利号:US-2006076299-A1 优先权日:2004-10-08 标 题 :Synthesis of bentonite clay-based iron nanocomposite and its use as a heterogeneous photo fenton catalyst 发明人:FENG JIYUN; YUE PO L; HU XIJUN; WONG SHIU K R 权利人:UNIV HONG KONG SCIENCE & TECHN 摘要:The present invention provides a method of synthesizing bentonite clay-based Fe nanocomposite, that may be used as a heterogeneous photo Fenton catalyst in advanced oxidation processes (AOP's) for wastewater treatment.
专利号:US-8735391-B2 优先权日:2008-09-26 标 题 :Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods 发明人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J 权利人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J; UNIV KANSAS 摘要:A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.
专利号:WO-2024129887-A1 优先权日:2022-12-13 标题:Biobased synthesis of glucodiamine 发明人:MILLET AGUSTIN; WOELK HANS-JOERG; LEE TONI M; CHAKRABARTI GAURAB; HUNT SEAN 权利人:SOLUGEN INC 摘要:A method of preparing glucodiamine, comprising contacting glucose with an enzyme oxidation catalyst under conditions suitable for the formation of glucodialdose; contacting glucodialdose with a nitrogen-containing compound under conditions suitable for the formation of glucodioxime; and reducing glucodioxime under conditions suitable for the formation of glucodiamine. A method of preparing glucodiamine, comprising contacting glucodioxime with a dehydration catalyst under conditions suitable for the formation of glucodinitrile; and reducing glucodinitrile under conditions suitable for the formation of glucodiamine. A chemoenzymatic method of producing a bio-based amide platform chemical, comprising: contacting glucose with a biocatalyst under conditions suitable for the formation of glucodialdose; contacting glucodialdose with a base under conditions suitable for the formation of glucodioxime; and contacting glucodioxime with a hydrogenation catalyst in the presence of hydrogen under conditions suitable for formation of glucodiamine.
专利号:US-2004267028-A1 优先权日:2001-09-24 标题 :Preparation and use of pyrrole derivatives for treating obesity 发明人:SMITH ROGER A; KLUENDER HAROLD C; SU NING; LAVOIE RICO C; FAN JIANMEI 权利人:SMITH ROGER A; KLUENDER HAROLD C; SU NING; LAVOIE RICO C; FAN JIANMEI 摘要:This invention relates to pyrrole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
专利号:US-11945725-B1 优先权日:2023-12-05 标题 :Synthesis of activated carbon using palm leaves and potassium permanganate 发明人:BALAL SAMAH BABIKER DAFFALLA; AL AMER ARWA ABDULHAMEED 权利人:UNIV KING FAISAL 摘要:A method of preparing an activated charcoal can include obtaining palm leaves; grinding the palm leaves; refluxing the ground palm leaves with sodium hydroxide (NaOH) to obtain a basic solution; draining the basic solution from the palm leaves; washing and drying the ground palm leaves; refluxing the dried ground palm leaves with potassium permanganate (KMnO4) to obtain a reaction mixture; heating the reaction mixture; washing the reaction mixture with hydrochloric acid (HCl); and drying the reaction mixture to obtain activated carbon. A method of removing a pollutant from an aqueous solution includes contacting the activated carbon as prepared in with the aqueous solution to remove organic dyes.