CAS: 102-97-6; N-Isopropylbenzylamine

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CAS号6852-56-8 N-苯亚甲基异丙醇胺 | CAS号108-18-9 二异丙胺 | CAS号100-46-9 苄胺 | CAS号100-52-7 苯甲醛 | CAS号75-31-0 异丙胺 | CAS号103-49-1 二苄胺 | CAS号67-64-1 丙酮 | CAS号67-63-0 异丙醇 | CAS号10229-64-8 N-Benzylidene-1... | CAS号35256-85-0 牧草胺 | CAS号6852-56-8 N-苯亚甲基异丙醇胺 | CAS号780-25-6 N-亚苄基苄胺 | CAS号100-52-7 苯甲醛 | CAS号10229-64-8 N-Benzylidene-1... | CAS号932-90-1 苯甲醛肟 | CAS号159330-32-2 N-benzylpropan-... | CAS号111267-94-8 N-benzyl-N-(tri... | CAS号5310-15-6 N-propan-2-ylbe... | CAS号14309-89-8 Benzenecarbothi...

苯甲酰溴置于氢氧化钾,Lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应 22.0H,反应生成N-苄基异丙胺
参考文献:Stereodynamics Of 2-(Diethylamino)Propane And 2-(Dibenzylamino)Propane. 1H And 13C{1H} DNMR Studies. Molecular Mechanics Calculations
标题:Stereodynamics Of 2-(Diethylamino)Propane And 2-(Dibenzylamino)Propane. 1H And 13C{1H} DNMR Studies. Molecular Mechanics Calculations
摘要:2-(Diethylamino)Propane (Deap) And 2-(Dibenzylamino)Propane (Dbap) Possess Similar Molecular Symmetries. Interconversion Among The Stable Equilibrium Conformations occurs By Inversion-Rotation At The Pyramidal Nitrogen And By Isolated Rotation About-Carbon-Nitrogen Bonds. In Deaf And Dbap,The Fact That Stable Equilibrium Conformations Cannot Have Destabilizing Syn-1,5 Interactions Between Methyl Or Phenyl Groups Limits The Number Of Equilibrium Conformations That Will Be Present At Concentrations High Enough To Be NMR Detectable. The H-1 And C-13{h-1} NMR Spectra Of Deaf At 100 K Show Two Diastereomeric Pairs Of Enantiomeric Conformations. One Pair Of Enantiomers Has The Isopropyl Methine Proton And Both Ethyl Methyl Groups Gauche To The Lone Pair (75%). The Other Pair Has The Methine Proton Anti To The Lone Pair With The Ethyl Methyl Groups Respectively Gauche And Anti To The Lone Pair (25%). The Barrier To Inversion-Rotation In Deaf (Delta G(Double Dagger) = 6.4 Kcal/mol) Is Higher Than Barriers To Isolated Rotation About Carbon-Nitrogen Bonds (Delta G(Double Dagger) = 5.3-5.7 Kcal/mol). The H-1 And C-13{h-1} NMR Spectra Of Dbap At 100 K Show Just One Pair Of Enantiomeric Conformations That Have The Isopropyl Methine Proton And Both Phenyl Groups Gauche To The Lone Pair. There Is No Evidence In The NMR Spectrum At 100 K For Those Conformations Of Dbap That Have A Phenyl Group Anti To The Lone Pair. The Barrier To Inversion-Rotation In Dbap (Delta G(Double Dagger) = 6.4 Kcal/mol) Is Higher Than The Barrier To Racemization Via Isolated Rotation About Carbon-Nitrogen Bonds (Delta G(Double Dagger) = 5.5 Kcal/mol). Molecular Mechanics Calculations Of Conformational Energies Are In Good Agreement With The Observed Conformational Preferences.
Doi:10.1021/ja00155A021

专利信息

专利号:US-2011124867-A1
优先权日:2007-12-18
标题 :Process and intermediates for the Synthesis of heterocyclic Substituted Piperazines with CXCR3 Antagonist Activity
发明人：CHEN FRANK XING; CUTARELLI TIMOTHY D; FU XIAYONG; LIANG XIAN; MCALLISTER TIMOTHY L; ORR ROBERT K; YIN JIANGUO; YONG KELVIN H; ZHU MAN
权利人:SCHERING CORP
摘要:The present invention relates to novel processes for the preparation of the compound of the Formula A45: n n n n n n n n n n or a physiologically acceptable salt, solvate or prodrug thereof, which has utility, for example, as a pharmaceutically active compound with CXCR3 antagonist activity, and to novel intermediates useful in the synthesis thereof.

专利号:US-8168556-B2
优先权日:2007-10-25
标 题 :Racemoselective synthesis of ansa-metallocene compounds, ansa-metallocene compounds, catalysts comprising them, process for producing an olefin polymer by use of the catalysts, and olefin homo- and copolymers
发明人：SCHULTE JOERG; SELL THORSTEN; THORN MATTHEW GRANT; WINTER ANDREAS; DIMESKA ANITA
权利人:SCHULTE JOERG; SELL THORSTEN; THORN MATTHEW GRANT; WINTER ANDREAS; DIMESKA ANITA; LUMMUS NOVOLEN TECHNOLOGY GMBH
摘要:A metallocene compound with the 4- and 7-positions on the indenyl moiety possessing large aromatic substituents is prepared in accordance with a method which produces substantially 100 percent racemic isomer. Advantageously, polymerization catalysts including the metallocene of the invention provide superior olefin polymerization results.

专利号:US-2022118094-A1
优先权日:2019-02-21
标题:Synthesis of biomimetic cell wall structure
发明人：WANG YONG; SHI PENG
权利人:PENN STATE RES FOUND
摘要:The present invention relates generally to methods of generating a biomimetic cell wall (BCW) on a target surface, compositions comprising the BCW, and methods of use of the compositions, including biomedical applications of the BCW coated compositions.

专利号:US-3862978-A
优先权日:1967-08-24
标 题:Catalytic synthesis of organic halogen compounds from an ethylenically unsaturated compound and a halogenated organic compound
发明人：DECKER DALTON L; MOORE CARL; TOUSIGNANT WILLIAM F
权利人:DOW CHEMICAL CO
摘要:Method for forming a chemical adduct of an ethylenically unsaturated compound with a halogenated organic compound having on a single carbon atom thereof at least two halogen atoms at least one of which is chlorine, bromine or iodine, characterized by employing a catalyst of which the essential members are copper and an amine selected from piperidine, substituted piperidines, cyclohexylamines and secondary amines on which the hydrocarbyl substituents are allyl, benzyl or lower alkyl radicals.

专利号:US-2002107391-A1
优先权日:2000-10-25
标 题:Process for the synthesis of an endothelin receptor antagonist
发明人：FREY LISA F; CHEN CHENG Y; LI JING; SONG ZHIGUO J; TAN LUSHI; TILLYER RICHARD D; TSCHAEN DAVID M; ZHAO MATTHEW M
摘要:The present invention relates to a practical and efficient way to synthesize the compound for the endothelin receptor antagonist involving a Grignard addition and a cyclization reaction to give a desired compound of the general formula shown below:

专利号:US-7199215-B1
优先权日:1999-01-15
标题 :Pseudopeptide, synthesis method, reagent and applications
发明人：BRIAND JEAN-PAUL; SEMETEY VINCENT; LIMAL DAVID
权利人:BIOMERIEUX SA
摘要:The invention concerns a pseudopeptide of at least 6 amino acids comprising at least a unit selected among the general formulae (I) and/or (II) wherein: R 1 , R 2 and R 3 each independently of one another represent a side-chain of amino acids and can be identical or different; X represents an oxygen or sulphur atom. The invention also concerns its synthesis process, a reagent containing it, a detection kit comprising such a reagent, a method for detecting an antigen or an antibody using said pseudopeptide, and antibody or and anti-idiotype and finally a therapeutic composition.