CAS: 10429-07-9; 3β-(P-Toluolsulfonyloxy)-Androstan-17-On

该化合物是一种合成有机化合物,属于类类类類固醇衍生物,其特点是在安诺斯坦主干骨的17个位置上存在一个氯酮功能组,这是类固醇化学的一个常见结构.由甲苯氨酸衍生的类苯甲酸组是一个良好的脱落组,使该化合物在各种化学反应中有用,特别是在核生殖替代反应中.该化合物一般是白色到非白色固体的,在有机溶剂中可溶解.其应用可能包括在有机合成中使用,特别是在其他类固衍生物或药用化学中.与许多类固烷衍生物一样,它可能展示生物活动,但具体的药理特性将取决于进一步的研究.应当注意到适当的处理和安全措施,因为Asylate组具有潜在的反应性.

英文名称3β-(P-Toluolsulfonyloxy)-Androstan-17-On
中文名称雄甾-3-[(4-甲苯)磺酰]氧基-5酮
CAS编号10429-07-9
分子式:C26H36O4S
分子量:444.63
产品CID: 81916
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: HNTMKSKJRZRWKS-AOWVUTIXSA-N
1S/C26H36O4S/c1-17-4-7-20(8-5-17)31(28,29)30-19-12-14-25(2)18(16-19)6-9-21-22-10-11-24(27)26(22,3)15-13-23(21)25/h4-5,7-8,18-19,21-23H,6,9-1…
计算化学: 氢键受体数4.0氢键供体数0.0可旋转键数3.0

物理性质

熔点164-165 °C(溶剂: benzene (71-43-2); cyclohexane (110-82-7))
沸点568.5±50.0 °C(预测)
密度1.18g/cm3 at 25°C
PSA:68.82
LogP:5.8 at 35°C and pH7
蒸汽压0Pa at 25°C
外观形态粉末

MSDS等安全信息

上下游产品

Epiandrosterone p-toluenesulfonyl chloride dehydroepiandrosterone androsterone acetate cis-androsterone 5α-androst-2-en-17-one 3α-Formoxy-5α-androstan-17-on

合成工艺路线路线简述

去氢表雄酮置于吡啶,Palladium 10% On Activated Carbon,氢气体系中,用乙醇用作溶剂,40.0 °C,275.8 Kpa 条件下,反应 18.0H,反应生成雄甾-3-[(4-甲苯)磺酰]氧基-5酮
参考文献: Neuroactive Steroids,Compositions,And Uses Thereof[fr] Stéroïdes Neuroactifs,Compositions,Et Leurs Utilisations
标题: Neuroactive Steroids,Compositions,And Uses Thereof[fr] Stéroïdes Neuroactifs,Compositions,Et Leurs Utilisations

海关参考信息

2905222000-香茅醇
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7442386-B2
优先权日:2001-08-16
标题:Synthesis and use of reagents for improved DNA lipofection and/or slow release prodrug and drug therapies
发明人：DIAMOND SCOTT L; GRUNEICH JEFFREY ALAN
权利人:UNIV PENNSYLVANIA
摘要:The invention relates to compositions and methods for a one-step synthetic technique for making cationic steroid or cationic drug molecules for use as delivery vehicles. The invention further relates to methods for using cationic steroid molecules in lipofection or transfection, delivery of drugs, and for treatment of inflammation and other diseases and disorders. The invention also relates to cationic steroid prodrugs and cationic prodrugs and to methods of modifying drugs.

专利号:WO-03015757-A1
优先权日:2001-08-16
标题:Synthesis and use of reagents for improved dna lipofection and/or slow release prodrug and drug therapies

专利号:US-9056048-B2
优先权日:2001-08-16
标题:Synthesis and use of cationic steroids for anti-inflammatory drug therapy
发明人：DIAMOND SCOTT L; GRUNEICH JEFFREY ALAN; FEIN DAVID E
权利人:DIAMOND SCOTT L; GRUNEICH JEFFREY ALAN; FEIN DAVID E; UNIV PENNSYLVANIA
摘要:The invention relates to compositions and methods for a one-step synthetic technique for making cationic steroid pharmaceutical compositions for use in treating inflammation and other diseases and disorders.

专利号:US-2009124591-A1
优先权日:2001-08-16
标题 :Synthesis and Use of Cationic Steroids for Anti-Inflammatory Drug Therapy

专利号:EP-1424998-A4
优先权日:2001-08-16
标题:SYNTHESIS AND USE OF REAGENTS TO IMPROVE DNA LIPOFECTION AND / OR DRUG THERAPIES AND SLOW RELEASE PROMOTERS

专利号:US-2005069577-A1
优先权日:2001-08-16
标题:Synthesis and use of reagents for improved DNA lipofection and/or slow release prodrug and drug therapies