CAS: 124443-68-1; 1-Tert-Butyl 4-Methyl Piperidine-1,4-Dicarboxylate

相似化合物

1690-75-1 7462-86-4 2971-79-1

上下游产品

CAS号67-56-1 甲醇 | CAS号84358-13-4 1-B°C-4-哌啶甲酸 | CAS号498-94-2 4-哌啶甲酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号2971-79-1 4-哌啶甲酸甲酯 | CAS号74-88-4 碘甲烷 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号3236-56-4 dipercarbonate ... | CAS号7462-86-4 4-哌啶甲酸甲酯盐酸盐 | CAS号1538-75-6 特戊酸酐 | CAS号578021-55-3 N-叔丁氧羰基-4-乙基哌啶-... | CAS号441774-09-0 4-(2-丙烯-1-基)-1,... | CAS号426842-70-8 1-B°C-4-烯丙基-4-哌啶甲酸 | CAS号913264-42-3 4-(3-异丙基-[1,2,4... | CAS号187834-88-4 1-B°C-4-哌啶甲酰肼 | CAS号84358-13-4 1-B°C-4-哌啶甲酸 | CAS号546086-95-7 2,8- 二氮杂螺[4,5]癸烷-1-酮 | CAS号724790-59-4 1-B°C-4-甲基哌啶-4-甲酸甲酯 | CAS号1023595-19-8 2,9-二氮杂螺[5.5]十一... | CAS号123855-51-6 N-B°C-4-哌啶甲醇

4-哌啶甲酸置于氯化亚砜,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 19.0H,反应生成N-Boc-4-哌啶甲酸甲酯
参考文献:56 个形状多样的 3D 片段的设计和合成.
标题:56 个形状多样的 3D 片段的设计和合成.
摘要:基于片段的药物发现现已广泛应用于制药行业的先导化合物开发.然而,片段筛选集合通常主要由扁平的二维分子组成.在此,我们描述了设计和合成 56 个 3D 二取代吡咯烷和哌啶片段的工作流程,这些片段占据了片段空间中代表性不足的区域(如主惯性矩 (Pmi) 分析所示).该片段集合的一个关键且独特的基础设计特征是在合成和合成之前对片段形状和构象多样性进行评估(通过考虑比全局最小能量构象异构体的能量高出高达 1.5 Kcal Mol-1的构象).也用于选择合成目标.3D 片段被设计为包含合适的合成手柄,以供将来的片段精加工使用.最后,通过将我们的 3D 片段与六个商业图书馆进行比较,很明显我们的馆藏具有较高的三维度和形状多样性.
Doi:10.1002/chem.202001123

专利信息

专利号:US-7825244-B2
优先权日:2005-06-10
标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
发明人：BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

专利号:US-9815816-B2
优先权日:2005-09-30
标 题 :Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline
发明人：BLIXT JORGEN; GOLDEN MICHAEL DAVID; HOGAN PHILIP JOHN; MARTIN DAVID MICHAEL GLANVILLE; MONTGOMERY FRANCIS JOSEPH; PATEL ZAKARIYA; PITTAM JOHN DAVID; SEPENDA GEORGE JOSEPH; SQUIRE CHRISTOPHER JOHN; WRIGHT NICHOLAS CARTWRIGHT ALEXANDER
权利人:ASTRAZENECA AB; GENZYME CORP
摘要:The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

专利号:US-2007021436-A1
优先权日:2005-06-10
标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis

专利号:CA-2611219-A1
优先权日:2005-06-10
标题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:AU-2006258056-A1
优先权日:2005-06-10
标 题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

专利号:CN-101243065-A
优先权日:2005-06-10
标 题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis