CAS: 136949-58-1; Iobitridol

上下游产品

dimethyl 5-amino-2,4,6-triiodo-1,3-benzenedicarboxylate 2,4,6-triiodo-5-aminoisophthalic acid

Dimethyl 5-Amino-2,4,6-Triiodo-1,3-Benzenedicarboxylate置于n,N-二甲基乙酰胺,三光气,三乙胺,Lithium Hydroxide体系中,用 四氢呋喃,乙醇,二氯甲烷,水 用作溶剂,化学反应 81.5H,反应生成碘比醇
参考文献:制备碘比醇的方法,其中间体及其制备方法
标题:制备碘比醇的方法,其中间体及其制备方法
摘要:本发明公开了制备碘比醇的方法,其中间体及其制备方法.具体公开了一种用于制备碘比醇的中间体m1 5‑(2‑异丙基‑1,3‑二氧己环‑5‑羰酰基)‑2,4,6‑三碘间苯二甲酸.此外,本发明还公开了所述中间体m1的制备方法以及由该中间体制备碘比醇的方法.本发明的中间体活性高,易制备,由该中间体合成碘比醇的方法时间短,合成方法简单,综合成本低,且反应目标物的收率和纯度高,因此适用于工业化生产.

专利信息

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-10836711-B2
优先权日:2017-02-10
标 题 :Method for the one-pot production of organo-iodinated compounds
发明人：PETTA MYRIAM; PELLINGHELLI STEPHAN
权利人:GUERBET SA
摘要:The present invention concerns a process for the preparation of organo-iodized compounds, as well as their preparation intermediates. More particularly, the present invention concerns a process for the preparation of organo-iodized compounds which can be used as preparation intermediates in the synthesis of iodized contrast agents.

专利号:US-11472767-B2
优先权日:2018-08-02
标 题 :Process for the monotopic preparation of intermediate organo-iodinated compounds for the synthesis of ioversol
发明人：STÉPHAN PELLINGHELLI; PETTA MYRIAM
权利人:GUERBET SA
摘要:A process for preparing an organo-iodinated compound, comprising the following steps:a) acylating 2,4,6-triiodo-5-aminoisophthalic acid of formula (A) below:to obtain an intermediate compound Ya;b) chlorinating the intermediate compound Ya to obtain an organo-iodinated intermediate compound Yb;c) amidating the organo-iodinated intermediate compound Yb to obtain an intermediate compound Yc; andd) deprotecting the intermediate compound Yc, the steps a), b), c) and d) being carried out without isolation of at least one intermediate compound chosen from Ya and Yc.

专利号:US-10836710-B2
优先权日:2016-12-05
标 题 :Mechanochemical synthesis of radiographic agents intermediates
发明人：BARGE ALESSANDRO; BARICCO FRANCESCA; CRAVOTTO GIANCARLO; FRETTA ROBERTA; LATTUADA LUCIANO
权利人:BRACCO IMAGING SPA
摘要:The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.

专利号:US-2022118123-A1
优先权日:2019-02-22
标 题 :Combination of ar antagonists and targeted thorium conjugates
发明人：HAMMER STEFANIE; HAGEMANN URS BEAT; HAENDLER BERNARD; LEJEUNE PASCALE; ZITZMANN-KOLBE SABINE; SCHATZ CHRISTOPH; KARLSSON JENNY
权利人:BAYER AG; BAYER AS
摘要:The present invention covers combinations of at least two components, component A and component B, comprising component A being PSMA-TTC, and component B being an antiandrogen selected form AR antagonists such as from cyproterone acetate, bicalutamide, flutamide, nilutamide, enzalutamide, apalutamide, darolutamide or keto-darolutamide, or an AR degrader such as ARV-110, or an ARN-terminal domain binder such as EPI-506, or an antisense oligonucleotide that reduces AR expression such as EZN-4176 or AZD-5312, or an androgen synthesis inhibitor such as abiraterone, particularly abiraterone acetate, seviteronel, galeterone, orteronel or ketoconazole, or a dual AR antagonist and androgen synthesis inhibitor such as ODM-204. Another aspect of the present invention covers the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of a hyper-proliferative disease.

专利号:US-2011104052-A1
优先权日:2007-12-03
标 题 :Methods of synthesis and use of chemospheres
发明人：BARNETT BRADLEY POWERS; GESCHWIND JEFFREY
权利人:UNIV JOHNS HOPKINS
摘要:The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.