CAS: 147624-13-3; 3-Fluoro-2-Methylbenzaldehyde

相似化合物

185147-06-2 699-90-1 114312-57-1

3-Fluoro-2-Methylbenzaldehyde Cyclohexylimine置于盐酸体系中,化学反应生成3-氟-2-甲基苯甲醛
参考文献:Directed Metalation Of Aromatic Aldimines With Lithium 2,2,6,6-Tetramethylpiperidide
标题:Directed Metalation Of Aromatic Aldimines With Lithium 2,2,6,6-Tetramethylpiperidide
摘要:N-Cyclohexyl Aromatic Aldimines Are Ortho-Lithiated Or O-Methyl-Lithiated With 2 Equiv Of Lithium 2,2,6,6-Tetramethylpiperidide (Ltmp) In Thf Solution It-15-Degrees-C. The Lithiated Intermediates Generally Reacted With Alkyl Halides Or Co2 To Provide Ortho-Functionalized Aldimine Products Which Could Be Readily Converted To The Corresponding Aldehydes By Hydrolysis With Aqueous 4 M Hci. Aromatic Aldimines Derived From (+/-)-Trans-2-Methylcyclohexylamine Or 3-Amino-2,4-Dimethylpentane Are Resistant Toward C=n Addition With 1 Equiv Of N-Buli At 0-Degrees-C In Thf Solution; However,They Are Also Surprisingly Resistant Toward Directed Metalation Reactions With Either Ltmp Or N-Buli. Exceptions To The Ortho-Directing And O-Methyl-Directing Effects Of The Aldimine Group Were Observed In A Reaction Of 3-Methylthiophene-2-Carboxaldehyde Cyclohexylimine (7) With Ltmp,Followed By Ch3I,Which Gave A 9:1 Mixture Of 3,5-Dimethylthiophene-2-Carboxaldehyde Cyclohexylimine (22) And 5-Ethyl-3-Methylthiophene-2-Carboxaldehyde Cyclohexylimine (23),And A Reaction Of P-Tolualdehyde 2,4-Dimethylpent-3-Ylimine (11) With Either N-Buli Or Ltmp,Followed By Ch3I,Which Gave P-Ethylbenzaldehyde 2,4-Dimethylpent-3-Ylimine (25).
Doi:10.1021/jo00061A020

专利信息

专利号:US-5679864-A
优先权日:1995-11-03
标题:Process for the synthesis of curcumin-related compounds
发明人：KRACKOV MARK HARRY; BELLIS HAROLD EDWARD
权利人:GENE PRINT INC
摘要:The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-6852711-B2
优先权日:1998-09-11
标题:HIV protease inhibitors
发明人：BOYER JR FREDERICK EARL; DOMAGALA JOHN MICHAEL; ELLSWORTH EDMUND LEE; GAJDA CHRISTOPHER ANDREW; HAGEN SUSAN ELIZABETH; LOVDAHL MICHAEL JAMES; LUNNEY ELIZABETH ANN; MARKOSKI LARRY JAMES; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:AGOURON PHARMA
摘要:The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

专利号:EP-0861223-B1
优先权日:1995-11-03
标 题:Process for the synthesis of curcumin-related compounds

专利号:WO-9716403-A1
优先权日:1995-11-03
标 题 :Process for the synthesis of curcumin-related compounds

专利号:EP-0861223-A1
优先权日:1995-11-03
标 题 :Process for the synthesis of curcumin-related compounds