专利号:US-2004266699-A1 优先权日:2001-10-04 标 题 :Flavonoid compounds capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells, relative synthesis and their use 发明人:PORTA AMALIA 摘要:The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such compounds are molecules of plant origin or synthetic. The invention also describes a method to identify, purify and chemically synthesize such flavonoid compounds and test their efficacy through their capacity to stimulate the transcription of stress genes and as a consequence, to interact with biological membranes with alteration of their relative physical state. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have applications in the areas of pharmaceuticals, more specifically in cosmetics and dermatology, for all those afections related to an alteration of the expression of stress genes.
专利号:EP-1232226-B1 优先权日:2000-09-08 标题:Synthesis of nanoparticles 发明人:HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKY CARSTEN; WELLER HORST; MEYSAMMY HEIKE; IBARRA FERNANDO 权利人:NANOSOLUTIONS GMBH 摘要:Production of inorganic nanoparticles that can be fluoresced consisting of a host material containing a dopant comprises using an organic solvent for liquid phase synthesis of the particles.
专利号:US-2010160244-A1 优先权日:2004-09-02 标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-6472190-B1 优先权日:2000-03-16 标 题:Biocatalytic synthesis of galloid organics 发明人:FROST JOHN W 权利人:UNIV MICHIGAN STATE 摘要:The present invention provides a bioengineered synthesis scheme for the production of gallic acid from a carbon source. Methods of producing gallic acid from a carbon source based on the synthesis scheme are also provided. The gallic acid produces from these methods can be further converted to pyrogallol. Methods for the biosynthesis of pyrogallol from gallic acid are also provided.
专利号:US-7211590-B2 优先权日:2002-08-01 标 题:Nitrosated proton pump inhibitors, compositions and methods of use 发明人:FANG XINQIN; GARVEY DAVID S; LETTS L GORDON 权利人:NITROMED INC 摘要:The invention describes novel nitrosated proton pump inhibitor compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated proton pump inhibitor compound, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating gastrointestinal disorders; facilitating ulcer healing; decreasing the recurrence of ulcers; improving gastroprotective properties, anti-Helicobacter pylori properties or antacid properties of proton pump inhibitors; decreasing or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds; treating bacterial infections and/or viral infections.
专利号:US-2025305010-A1 优先权日:2022-05-08 标题:Lipid compositions and methods of producing same 发明人:KEREN TOMER; ELLA EZRA; ARGOV-ARGAMAN NURIT 权利人:WILK TECH INTERNATIONAL LTD; YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD 摘要:Provided is a method of increasing lipid synthesis or accumulation in mammary epithelial cells (MECs) culture and optionally secretion therefrom. The method comprising contacting the MECs with an LXR agonist in the presence of a fatty acid to thereby increase lipid synthesis or accumulation and optionally secretion of lipids. Also provided is a method of producing synthetic fat globules, the method comprising: (a) isolating lipid droplets from cells in culture; (b) encapsulating the droplets with a lipid bilayer, thereby producing synthetic fat globules. Also provided are compositions produced thereby.
参考标题:Efficient Synthesis Of γ -Ddb 作者:Junbiao Chang,Xiaohe Guo,Senxiang Cheng,Ruiyun Guo,Rongfeng Chen,Kang Zhao |发布日期:2004.5 摘要:Synthesis Of Gamma-Ddb, Which Is Another Family Member Of Gamma-Ddb (Dimethyl 4,4(')-Dimethoxy-5,6,5('),6(')- Dimethylenedioxybiphenyl-2,2(')-Dicarboxylate), Is Described. The Unsymmetric Isomer (Gamma-Ddb) Was Constructed By A Linker-Directed Intramolecular Ullmann Coupling Reaction, Followed By The Cleavage Of The Linker And Re-Esterification.
合成参考文献
参考文献:10.1107/s1600536811007471 摘要:Hirun N, Saithong S, Pakawatchai C, Tantishaiyakul V. 3,4,5-Trihy-droxy-benzoic acid. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o787.