二氧化碳置于正丁基锂,二异丙胺,盐酸体系中,用 四氢呋喃,正己烷,水 用作溶剂,化学反应 3.0H,以83%的收率获得2,3-二氯吡啶-4-甲酸 参考文献: 6-(Pyridinyl)-4-Pyrimidone Derivates As Tau Protein Kinase 1 Inhibitors[fr] Compose Pyrimidone 标题: 6-(Pyridinyl)-4-Pyrimidone Derivates As Tau Protein Kinase 1 Inhibitors[fr] Compose Pyrimidone
专利号:US-6444820-B1 优先权日:1995-04-07 标题:Process for the manufacture of camptothecin derivatives 发明人:HENEGAR KEVIN E; SIH JOHN C 摘要:This invention discloses and claims novel intermediates and procedures for the synthesis of camptothecin derivatives, such as irinotecan, and other compounds related to the synthesis of CPT-11. Related procedures and compounds are also disclosed, such as a novel method of making mappicine.
专利号:CN-101516872-A 优先权日:2006-07-20 标 题 :(2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2 -Synthesis of forminonitrile
专利号:CN-104447617-A 优先权日:2014-12-17 标题 :Synthesis and application of a class of nitroaminoguanidine compounds containing 1,2,3-thiadiazole
专利号:EP-3848356-A1 优先权日:2020-01-07 标 题 :Aryl-n-aryl derivatives for treating a rna virus infection 权利人:ABIVAX; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER; INST CURIE 摘要:The present invention relates to a compound of formula (I):n nwherein: n X 2 represents a -CO-NR k - group, a -NR' k -CO- group, a -O- group, a -CO- group, a -SO 2 -group, a -CS-NH- group, a -CH 2 -NH-, an ngroup, or a heterocyclyl, wherein the heterocyclyl is a 5- or 6-membered ring comprising 1, 2, 3 or 4 heteroatoms selected from O, S and/or N; Y 2 represents a hydrogen atom, a halogen atom, a hydroxyl group, a morpholinyl group, optionally substituted by a (C 1 -C 4 )alkyl group or a trifluoromethyl group, a bridged morpholinyl group, a bridged bicycloalkyl group, a piperidinyl group, a (C 1 -C 4 )alkenyl group, a -PO(OR a )(OR b ) group, or a -CR 1 R 2 R 3 group, or any of its pharmaceutically acceptable salt. n The present invention further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.
专利号:CN-104447617-B 优先权日:2014-12-17 标 题 :Synthesis and application of a class of nitroaminoguanidine compounds containing 1,2,3-thiadiazole
专利号:CN-101921244-A 优先权日:2010-09-02 标题 :Derivative of 4-methyl-1,2,3-thiadiazole containing 4-(1,1,2,2-tetrafluoroethoxy)-3,5-dichlorobenzene amino and synthesis method and application thereof
参考文献:10.1007/s11033-020-05719-6 摘要:Li C, Wang K, Zheng Y. Redox status regulates subcelluar localization of PpTGA1 associated with a BABA-induced priming defence against Rhizopus rot in peach fruit. Molecular Biology Reports. 2020 Aug 13;47(9):6657–68. doi: 10.1007/s11033-020-05719-6.