CAS: 326-62-5; 2-(2-Fluorophenyl)Acetonitrile

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CAS号773837-37-9 sodium cyanide | CAS号345-35-7 邻氟氯苄 | CAS号446-48-0 2-氟溴苄 | CAS号446-52-6 邻氟苯甲醛 | CAS号140-29-4 苯乙腈 | CAS号95-52-3 邻氟甲苯 | CAS号143-33-9 氰化钠 | CAS号462-06-6 氟苯 | CAS号75-05-8 乙腈 | CAS号57486-67-6 2-氟苯乙酸甲酯 | CAS号451-82-1 邻氟苯乙酸 | CAS号100-17-4 4-硝基苯甲醚 | CAS号30490-54-1 2-chloroacridin... | CAS号77985-59-2 2-chloroacridin... | CAS号77778-85-9 2-FLUORO-4'-NIT... | CAS号252002-43-0 4-(2-fluorophen... | CAS号28049-63-0 1-(2-氟苯基)环丁烷-1-腈 | CAS号204205-33-4 2-溴-2-(2-氟苯基)-1... | CAS号64123-77-9 3-氟苯乙酸甲酯

1-(2,2-Difluorovinyl)-2-Fluorobenzene置于ammonium Hydroxide体系中,用 乙腈 用作溶剂,化学反应 24.0H,以62%的收率获得2-氟苯基乙腈
参考文献:从 Gem-二氟烯烃中快速简单地获得 α-(杂)芳基乙腈
标题:从 Gem-二氟烯烃中快速简单地获得 α-(杂)芳基乙腈
摘要:开发了一种可扩展的偕二氟烯烃氰化为(杂)芳基乙腈衍生物的方法.该策略具有反应条件温和,产率高,底物范围广,官能团耐受性广等特点.值得注意的是,在该反应中,氨水为"cn"试剂提供了"n"源,并且完全避免使用有毒的氰化试剂或金属催化剂.因此,我们为芳基乙腈的合成提供了一种绿色替代方法.
Doi:10.1021/acs.Orglett.1C04336

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:WO-0015621-A1
优先权日:1998-09-11
标 题:Process for the synthesis of n-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one

专利号:US-4369322-A
优先权日:1978-12-15
标 题 :Process for the production of substituted acetonitriles
发明人：SCHALKE PETER; KLEEMANN AXEL
权利人:DEGUSSA
摘要:The known synthesis for the production of aromatic substituted acetonitriles by reaction of aromatic substances with cyanogen chloride in the gas phase is improved by feeding the starting materials in gaseous form and separated from each other into the reactor. The process can be used to synthesize in general aromatic and especially hetero-aromatic substituted acetonitrile.

专利号:EP-1112259-A1
优先权日:1998-09-11
标题 :Process for the synthesis of n-benzyl-3-(4-fluorophenyl)-1,4-oxazin-2-one

专利号:CN-119707744-A
优先权日:2024-12-13
标题 :A method for catalytic synthesis of alpha-alkyl butyronitrile compounds