CAS: 3597-91-9; [1,1'-Biphenyl]-4-Ylmethanol

上下游产品

CAS号18282-51-4 4-碘苄醇 | CAS号98-80-6 苯硼酸 | CAS号873-76-7 4-氯苄醇 | CAS号92-92-2 4-苯基苯甲酸 | CAS号591-50-4 碘苯 | CAS号873-75-6 4-溴苄醇 | CAS号2633-57-0 三烯丙基(苯基)硅烷 | CAS号3218-36-8 4-联苯甲醛 | CAS号934-56-5 三甲基苯基锡 | CAS号1122-91-4 对溴苯甲醛 | CAS号102477-83-8 biphenyl-4-prop... | CAS号3815-20-1 4-联苯基甲酰胺 | CAS号37729-18-3 2-([1,1'-联苯]-4-基)乙醇 | CAS号613-42-3 4-苄基联苯 | CAS号1885-53-6 1H-Isoindole-1,... | CAS号92-92-2 4-苯基苯甲酸 | CAS号3218-36-8 4-联苯甲醛 | CAS号29079-00-3 4-乙炔联苯 | CAS号92-52-4 联苯 | CAS号59662-26-9 4-己酰基联苯

4-联苯乙酸置于disodium Hydrogenphosphate,水,N,N,N,N-Tetraethylammonium Tetrafluoroborate体系中,用 二氯甲烷 作为反应溶剂,以18 %的收率获得产物联苯-4-甲醇
参考文献:与亲核试剂的电化学脱羧交叉偶联
标题:与亲核试剂的电化学脱羧交叉偶联
摘要:与亲核试剂的直接电化学脱羧交叉偶联已被开发用于合成结构多样的氟化物,醇,醚,酯和胺产物.该策略利用了商业库中这些构建模块的现成可用性,以及电化学系统提供的温和且无氧化剂的条件.
DOI:10.1002/chem.202402124

专利信息

专利号:US-5712367-A
优先权日:1989-10-02
标 题:Process for the solubilization of peptides and process for peptide synthesis
发明人：BERNARD JEAN-MARIE; BOUZID KAMEL; GERVAIS CHRISTIAN
权利人:RHONE POULENC CHIMIE
摘要:A process is disclosed for making peptides soluble in a water-immiscible organic solvent, comprising linking a lipophilic group with an amide or ester bond to the terminal carboxyl group of said peptide; when the lipophilic group is linked to L-serine, a molecule is obtained with a solubility in water at 25 DEG C. of less than 30 g/liter. This lipophilic group is non-polymeric and chemically defined. A process is also disclosed for the synthesis of peptides, optionally protected, in a liquid medium, wherein the starting material is an amino acid or peptide made soluble in an organic medium by a lipophilic group A-L linked to the carboxyl function of the starting amino acid or peptide, and are added to amino acids or peptides to be condensed which are activated on their acid function and protected on their amine function and are optionally protected on their side chain. The peptides resulting from the synthesis are used, where appropriate, for the synthesis of medicinal products, vaccines or agri-foodstuff or plant-protection.

专利号:US-8710261-B2
优先权日:2005-02-22
标 题:5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases
发明人：PALLE VENKATA P; SATTIGERI VISWAJANANI JITENDRA; KHERA MANOJ KUMAR; VOLETI SREEDHARA RAO; RAY ABHIJIT; DASTIDAR SUNANDA G
权利人:PALLE VENKATA P; SATTIGERI VISWAJANANI JITENDRA; KHERA MANOJ KUMAR; VOLETI SREEDHARA RAO; RAY ABHIJIT; DASTIDAR SUNANDA G; RANBAXY LAB LTD
摘要:The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R 1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R 2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR 4 R 5 , —NHC(â•?Y)R 4 , —NHC(â•?Y)NR 5 R χ , —NHC(â•?O)OR 4 , —NHSO 2 R 4 , C(â•?Y)NR 4 R 5 , C(â•?O)OR 6 [wherein Y is oxygen or sulphur], OR 5 , —O(Câ•?O)NR 4 R 5 , O-acyl, S(O) m R 4 , —SO 2 N(R 4 ) 2 , cyano, amidino or guanidino [wherein R 4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R 5 is hydrogen or R 4 ; R x is R 4 or —SO 2 N(R 4 ) 2 and R 6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R 3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR 4 , —OC(â•?O)NR 4 R 5 , O-acyl, NH 2 , NR 4 R 5 , —NHC(â•?Y)R 4 , —NHC(â•?Y)NR 5 R x , —NHC(â•?O)OR 4 , —NHSO 2 R 4 , and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterize by over-expression and over-activation of an matrix metalloproteinase, using the compounds.

专利号:US-9272260-B2
优先权日:2009-08-14
标 题 :Methods of synthesis and purification by use of a solid support
发明人：HAMMOND GERALD B; XU BO
权利人:HAMMOND GERALD B; XU BO; UNIV LOUISVILLE RES FOUND
摘要:Disclosed herein are novel methods of using polymeric adsorbent resin for chemical synthesis and the purification of product therefrom. Also disclosed herein is a novel method of using silica gel for the combination of chemical reaction and chromatography into a single step. The methods disclosed herein increase the efficiency of chemical synthesis processes. Accordingly, the utility of the methods disclosed herein includes the ability to automate chemical synthesis and purification of the resulting products.

专利号:US-6147159-A
优先权日:1998-09-30
标 题 :Compositions for organic synthesis on solid phase and methods of using the same
发明人：HU YONGHAN; LABADIE JEFFREY W; PORCO JR JOHN ANTHONY; TROST BARRY MARTIN
权利人:ARGONAUT TECHNOLOGIES
摘要:A modified solid support for use in solid phase synthesis which comprises: a solid support having a linker group extending therefrom having the general formula: wherein R1 and R2 are each independently selected from the group consisting of alkyl, cycloalkyl, aryl, alkoxy, aryloxy, fluorine, chlorine, iodine and bromine.

专利号:US-9006491-B2
优先权日:2009-10-22
标题 :Structure and method for synthesizing and using dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate
发明人：MA SHENGMING; LÃœ BO; FU CHUNLING
权利人:MA SHENGMING; LÃœ BO; FU CHUNLING; UNIV ZHEJIANG
摘要:The current invention relates to the structure, synthesis of dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, as well as its applications in the palladium catalyzed carbon-chlorine bond activation for Suzuki coupling reactions and carbon-nitrogen bond formation reactions. The dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate could coordinate with the palladium catalyst to activate the inert carbon-chlorine bond highly selectively and catalyze Suzuki coupling reaction with arylboronic acid or carbon-nitrogen bond formation reaction with organic amines. The current invention uses only one step to synthesize dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate is stable in the air. Compared with known synthetic routes of ligands used in activating carbon-chlorine bonds, the method of current invention is short, easy to operate. Moreover, with this type of ligands, the Suzuki coupling products of optically active chlorolactones and arylboronic acids would maintain their configuration and optical purity.

专利号:CN-117865845-A
优先权日:2024-01-22
标题 :Application of ferric oxide to catalytic three-step series atom economic synthesis of imine or derivative thereof by using aromatic nitro compound and benzyl alcohol compound