CAS: 69-78-3; 5,5'-Disulfanediylbis(2-Nitrobenzoic Acid)

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100-32-3 1155-00-6 1227-49-2

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CAS号629-45-8 二丁基二硫醚 | CAS号18430-02-9 2-nitro-5-merca... | CAS号30211-77-9 2-硝基-5-硫氰基苯甲酸 | CAS号15139-21-6 TNB | CAS号71899-86-0 5-(2-氨基乙基)二硫-2-硝基苯甲酸 | CAS号822-27-5 二正辛基二硫 | CAS号5586-15-2 2-萘二硫醚

硫代硝基苯甲酸置于过氧化氢异丙苯体系中,化学反应生成 5,5'-二硫双(2-硝基苯甲酸)
参考文献:在共聚物囊泡上构建人工谷胱甘肽过氧化物酶活性位点.
标题:在共聚物囊泡上构建人工谷胱甘肽过氧化物酶活性位点.
摘要:为了构建有效的gpx模拟物,开发了一种制备带有gpx活性位点的基于聚合物的囊泡的新方法.基于聚苯乙烯-嵌段-聚[三(乙二醇)甲基醚丙烯酸酯] S(ps-Pmeo 3 Mas)合成了一系列带有识别和催化位点的嵌段共聚物).通过改变功能性共聚物的摩尔比,通过共混这些功能性共聚物进行自组装,可以获得具有gpx活性的囊泡.通过共混过程构建的最佳gpx模拟物表现出高催化活性,并充当具有典型饱和动力学行为的真正催化剂.该方法对于设计其他酶模拟物可能是有益的,并且可以为构建其他生物学相关的功能纳米颗粒提供启示.
DOI:10.1002/mabi.201000179

专利信息

专利号:US-7041479-B2
优先权日:2000-09-06
标题 :Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:TRUSTESS OF THE LELAND STANFOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-5981733-A
优先权日:1996-09-16
标 题:Apparatus for the chemical synthesis of molecular arrays
发明人：GAMBLE RONALD C; THERIAULT THOMAS P; BALDESCHWIELER JOHN D
权利人:INCYTE PHARMA INC
摘要:An apparatus for the automated synthesis of molecular arrays. A jetting device is employed along with a reaction chamber to dispense reagents used in the synthesis onto the substrate. A positioning system moves the substrate from the jet to the reaction chamber. A controller controls the movement of the substrate and the application of the reagents so that the synthesis is carried out according to a pre-determined procedure. The apparatus will synthesize nucleotides in an array of micron-size spots according to a pattern selected by the operator immediately prior to synthesis.

专利号:US-6548276-B2
优先权日:2000-09-06
标题:Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-7691968-B2
优先权日:2002-05-03
标题:Process for the synthesis of peptides amides by side-chain attachment to a solid phase
发明人：EVANS DAVID JOHN; SIMPKIN DEAN STEVEN ANTHONY; WELLINGS DONALD ALFRED; ATHERTON ERIC
权利人:AVECIA BIOLOG LTD
摘要:A process is provided for the solid-phase synthesis of a peptide amide which comprises attaching an α-nitrogen protected Cα-carboxamide amino acid to a solid support by its side chain, removing the α-nitrogen protecting group, assembling a peptide chain on said α-nitrogen and then cleaving the assembled peptide amide from the solid support. Novel amino acid analogues, peptide amides and solid-phase supports are also provided.

专利号:US-4670563-A
优先权日:1984-06-20
标题 :Imidazolides as intermediates for the synthesis of cytotoxic conjugates
发明人：JANSEN FRANZ; GROS PIERRE
权利人:SANOFI SA
摘要:Imidazolides of the formula: ##STR1## in which: E represents an inert spacing structure; and n G represents a group: ##STR2## or a group --S--S--X, in which X is an activating group. Application: synthesis of cytotoxic conjugates.

专利号:WO-2011011342-A9
优先权日:2009-07-20
标题:Synthesis of desmopressin
发明人：SRIVASTAVA KRIPA S
权利人:MALLINCKRODT INC; SRIVASTAVA KRIPA S
摘要:The present invention provides a process for the production of desmopressin. In particular, the process provides a process for solid phase synthesis of desmopressin using cyclization of the peptide on the resin.