CAS: 776-76-1; Diphenylmethylsilane

上下游产品

CAS号34557-54-5 methane | CAS号775-12-2 二苯基硅烷 | CAS号766-77-8 二甲基苯烷 | CAS号75-54-7 甲基二氯硅烷 | CAS号108-86-1 溴苯 | CAS号591-50-4 碘苯 | CAS号766-08-5 甲基苯基硅烷 | CAS号16853-85-3 氢化铝锂 | CAS号144-79-6 二苯基甲基氯硅烷 | CAS号72443-54-0 Benzyldimethyl[... | CAS号144-79-6 二苯基甲基氯硅烷 | CAS号1071-38-1 (二甲氨基亚甲基)二甲基氯化铵 | CAS号379-50-0 三苯甲基氟硅烷 | CAS号807-28-3 1,3-二甲基-1,1,3,3... | CAS号18848-26-5 methyl-[2-[meth... | CAS号1009109-35-6 (methyldiphenyl... | CAS号829-85-6 二苯基膦 | CAS号2857-97-8 三甲基溴硅烷 | CAS号4460-16-6 o-[α-phenylsulf... | CAS号75-78-5 二甲基二氯硅烷

2-溴氯苯置于magnesium体系中,用 四氢呋喃 作为反应溶剂,化学反应 48.0H,反应生成 二苯甲基硅烷
参考文献:Simplified Approach To Silaanthrones And Disilaanthracenes
标题:Simplified Approach To Silaanthrones And Disilaanthracenes
摘要:
DOI:10.1016/0022-328X(84)85185-2

专利信息

专利号:US-7956011-B2
优先权日:2005-05-04
标题:Materials and methods for the photodirected synthesis of oligonucleotide arrays
发明人：SERAFINOWSKI PAWEL JERZY; GARLAND PETER BRYAN
权利人:CANCER RES INST ROYAL
摘要:Materials and methods for photodirected synthesis of oligonucleotide arrays on a solid substrate by photodirected synthesis are disclosed which employ a film formed from (i) a photoacid generator that on photolysis generates acid that is capable of directly removing the protecting group of the linker molecules or oligonucleotides and (ii) a polymer substantially lacking electronegative heteroatoms that are capable of hydrogen bonding with photogenerated acid. Methods of synthesizing an oligomer arrays are also described that use a film that restricts diffusion of reactants and products on the substrate during synthesis of the array and which includes a precursor of a deprotecting reagent. The method involves removing one or more of the non-required products of the deprotection reaction from the reactive array elements at which they are produced during the reaction, in order to displace the deprotection reaction towards completion.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-7893283-B2
优先权日:2004-06-04
标题:Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediates.

专利号:WO-2008032104-A1
优先权日:2006-09-15
标题:One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：WALKER ROSS THOMSON; NAIDU RAGINA
权利人:CHATHAM BIOTEC LTD; WALKER ROSS THOMSON; NAIDU RAGINA
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction, of protecting the C-10 and attaching a side chain at C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and intermediates used therein.

专利号:US-7202370-B2
优先权日:2003-10-27
标 题 :Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
发明人：NAIDU RAGINA
权利人:CONOR MEDSYSTEMS INC
摘要:A method is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel from 9-dihydro-13-acetylbaccatin III. The preparation of a suitably protected baccatin III backbone from 9-dihydro-13-acetylbaccatin III, and the insertion of the phenylisoserine side chain onto the protected baccatin III from 9-dihydro-13-acetylbaccatin III to form the taxane derivatives, paclitaxel and docetaxel is disclosed.