CAS: 95-92-1; Diethyl Oxalate

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CAS号64-17-5 乙醇 | CAS号40227-15-4 N,N'-diacetyloxamide | CAS号144-62-7 草酸 | CAS号105-53-3 丙二酸二乙酯 | CAS号148705-17-3 diisopropenyl o... | CAS号471-46-5 草酰二胺 | CAS号1608-14-6 N,N,N',N'-tetra... | CAS号109-95-5 亚硝酸乙酯 | CAS号201230-82-2 carbon monoxide | CAS号553-90-2 草酸二甲酯 | CAS号110314-88-0 diethyl 2-[2-(d... | CAS号106532-14-3 ethyl 2-(2-benz... | CAS号10471-29-1 3,4-dioxo-2,5-d... | CAS号6362-63-6 3-氰基-3-苯基丙酮酸乙酯 | CAS号1114-91-6 °Ctane-2,4,5,7-... | CAS号68854-18-2 三氧代庚二酸二乙酯 | CAS号666831-73-8 2,4,6,7,9-penta... | CAS号615-79-2 乙酰丙酮酸乙酯 | CAS号109735-80-0 ethyl 1H-perimi... | CAS号110193-60-7 (3-三氟甲基苯基)乙醛酸乙酯

丙二酸二乙酯置于aluminum (Iii) Chloride,Oxone体系中,用 水 作为反应溶剂,化学反应 0.17H,以95%的收率获得产物草酸二乙酯
参考文献:酮在水介质中介导的β-酮酯和1,3-二酮的氧化裂解为α-酮酯和1,2-二酮.
标题:酮在水介质中介导的β-酮酯和1,3-二酮的氧化裂解为α-酮酯和1,2-二酮.
摘要:已经开发了一种直接合成α-酮酸酯和1,2-二酮的通用且高效的方法.该方法利用了oxone /三氯化铝系统介导的各种β-酮酯和1,3-二酮的氧化裂解.简单的一步氧化反应在水性介质中选择性进行,从而以高收率,较短的反应时间和环境友好的条件提供产物.
DOI:10.1021/jo4009047

专利信息

专利号:US-2025019732-A1
优先权日:2023-07-07
标 题:Method for chemical-biological cascade synthesis of l-phosphinothricin and mutants therefor
发明人：XUE YAPING; CHENG FENG; ZOU SHUPING; XU JIANMIAO; ZHENG YUGUO
权利人:UNIV ZHEJIANG TECHNOLOGY
摘要:A method for chemical-biological cascade synthesis of L-phosphinothricin is carried out as follows: 3-(methylethoxyphosphinyl) ethyl propionate is synthesized by addition reaction from diethoxymethylphosphine and acrylic acid, then a condensation reaction is carried out with 3-(methylethoxyphosphinyl) ethyl propionate and sodium ethoxide as reactants, then the product is subjected to a hydrolysis reaction with diethyl oxalate to synthesize 4-(hydroxymethylphosphinyl)-2-oxobutyric acid, and finally, L-phosphinothricin is catalytically synthesized by taking 4-(hydroxymethylphosphinyl)-2-oxobutyric acid as a raw material, and using highly active and stable wet cells co-expressing phsophinothricin dehydrogenase and alcohol dehydrogenase or co-expressing a phsophinothricin dehydrogenase mutant and alcohol dehydrogenase as a biocatalyst, thereby solving the problems of existing L-phosphinothricin synthesis being tedious, low asymmetric amination reduction activity and poor stability.

专利号:US-4026911-A
优先权日:1976-02-23
标 题:Process for the preparation of ketoalkynoic acids and use of the process in an improved synthesis of 2-(substituted)-cyclo-pentane-1,3,4-triones
发明人：REVERMAN LAWRENCE FRANCIS
权利人:MILES LAB
摘要:Reaction of a 2-methyl-2-(alkenyl)-1,3-dioxolane with an α,ω-dihalogenoalkane to obtain a 2-methyl-2-(ω-chloroalkynyl)-dioxolane, conversion of the latter to a corresponding nitrile, and hydrolysis of the nitrile to form a ketoalkynoic acid is a novel process for preparing the acid. n Use of the process in the synthesis of 2-(substituted)-cyclopentane-1,3,4-triones improves that synthesis.

专利号:WO-2025134143-A1
优先权日:2023-12-19
标题 :A method for the synthesis of substituted anthranilic amide compounds, intermediates and salts thereof
发明人：MALVIYA NITIN JAIKANT; SINGH VIPENDER; MAL SANJIB; YADAV SANTOSH; SHAH JIGARKUMAR HARKISHANDAS; KAVITAKE SANTOSH GIRIDHAR; BORHADE AJIT SAHEBRAO; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of compounds of formula (I) or a salt thereof, wherein R is selected from hydrogen, halogen, cyano, C1-C12 alkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, or C3-C8 cycloalkyl; R4 is selected from hydrogen, C1-C12 alkyl, C2-C12 alkenyl, C2-C12 alkynyl, C1-C12 haloalkyl, C2- C12 haloalkenyl, C2-C12 haloalkynyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C3-C8 cycloalkyl, or C3-C8 cycloalkyl-C1-C10 alkyl; and n represents an integer selected from 0-4. The process further comprises the synthesis of an anthranilic diamide compound of formula (A).

专利号:US-2023339906-A1
优先权日:2020-09-26
标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

专利号:US-5523411-A
优先权日:1994-03-14
标题 :Synthesis of mitomycin and its analogs
发明人：JIMENEZ LESLIE; WANG ZHENG
权利人:UNIV RUTGERS
摘要:The present invention relates to the synthesis of mitomycin and analogs thereof that are useful as anticancer antibiotics. The invention further relates to analogs of mitomycin, which can be prepared according to the methods of synthesis provided. The synthetic method of the invention provides for reacting a derivitized indole with a dialkylvinylsulfonium salt to yield a tricyclic skeleton having the precursors of the fourth ring in one step, followed by an oxidation step or steps to close the fourth ring and prepare mitomycin or a related compound.

专利号:WO-2018019549-A1
优先权日:2016-07-28
标 题:Dioxolanone intermediate useful in the synthesis of homoharringtonine
发明人：ALLEGRINI PIETRO; CATTANEO CRISTIAN; CICERI DANIELE; GAMBINI ANDREA; PETERLONGO FEDERICO; CERISOLI LUCIA; LOMBARDO MARCO
权利人:INDENA SPA
摘要:The invention discloses 2-((2R,4R)-4-(4-(benzyloxy)-4-methylpent-2-yn-1-yl)-2-(tert-butyl)-5-oxo-1,3-dioxolan-4-yl)acetic acid of formula (XIX), a process for its preparation and processes for its conversion into enantiomerically pure (R)-2-(2-methoxy-2-oxoethyl)-6,6-dimethyltetrahydro-2H-pyran-2-carboxylic acid of formula (I), a molecule useful for the synthesis of Homoharringtonine.