CAS: 1006376-63-1; (S)-2-(3,4-Difluorophenyl)Oxirane

相似化合物

111991-13-0 1414348-36-9 253161-54-5

上下游产品

2-(3,4-二氟苯基)环氧乙烷 2-(3,4-Difluorophenyl)Oxirane 111991-13-0
(S)-1-(3,4-Difluorophenyl)-1,2-Ethanediol
(1S)-2-氯-1-(3,4-二氟苯基)乙醇 (S)-2-Chloro-1-(3,4-Difluorophenyl)Ethanol 1006376-60-8
2-氯-1-(3,4-二氟苯基)乙醇 1-Difluorphenyl-2-Chloraethanol 51336-97-1

1,2-二氟苯置于aluminum (III) Chloride,葡萄糖,水,Sodium Carbonate,Sodium Hydroxide体系中,用 甲苯 用作溶剂,化学反应 15.0H,反应生成(2S)-2-(3,4-二氟苯基)环氧乙烷
参考文献:一种替格瑞洛中间体的制备方法
标题:一种替格瑞洛中间体的制备方法
摘要:本发明公开一种替格瑞洛中间体的制备方法,以邻二氟苯和氯乙酰氯为起始原料,经过付克酰基化反应,生物酶发酵技术不对称还原反应,环合反应,环丙烷化反应,高收率,高对映选择性,高纯度得到替格瑞洛的关键中间体(1R,2R)‑2‑(3,4‑二氟苯基)环丙烷甲酸乙酯.该方法能够实现工业化生产,该方法能耗低,污染少,绿色清洁,收率高,纯度高,节约成本,产品质量稳定,适合大规模工业化稳定生产.

专利信息

专利号:US-2018148745-A1
优先权日:2015-05-26
标题:Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor
发明人：ARNOLD FRANCIS H; RENATA HANS; MCINTOSH JOHN A; LEWIS RUSSELL D; KAN SEK BIK JENNIFER; HERNANDEZ KARI; COELHO PEDRO; ROZZELL DAVID; ZHANG CHEN
权利人:CALIFORNIA INST OF TECHN; PROVIVI INC
摘要:The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.

专利号:EP-3303267-A2
优先权日:2015-05-26
标 题:Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor

专利号:WO-2016191612-A2
优先权日:2015-05-26
标 题 :Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor